A5084424227- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Neuroscience of respiration and sleep
- Lipoproteins and Cardiovascular Health
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Conditions and Treatments
- Vasculitis and related conditions
- Cardiovascular and Diving-Related Complications
- Vascular anomalies and interventions
- Streptococcal Infections and Treatments
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Autoimmune and Inflammatory Disorders Research
- Pericarditis and Cardiac Tamponade
- Neonatal and fetal brain pathology
University of Amsterdam
2008-2025
Emma Kinderziekenhuis
2014-2024
Amsterdam University Medical Centers
2019-2024
Leiden University
2021-2022
Amsterdam UMC Location University of Amsterdam
2011-2021
Leiden University Medical Center
2021
University Medical Center
2021
University of Groningen
2019
Radboud University Nijmegen
2015
Erasmus MC - Sophia Children’s Hospital
2015
Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging, and laboratory markers in children presenting with novel multisystem inflammatory syndrome associated coronavirus disease 2019 (COVID-19) infection. Methods: This real-time internet-based survey has been endorsed by Association for European Paediatric Congenital Cardiologists Working Groups Cardiac Imaging Cardiovascular Intensive Care. Children 0 18 years age admitted a hospital between...
We aimed to establish consensus for reporting recommendations relating participant characteristics in tendon research. A scoping literature review of tendinopathy studies (Achilles, patellar, hamstring, gluteal and elbow) was followed by an online survey face-to-face meeting with expert healthcare professionals (HCPs) at the International Scientific Tendon Symposium, Groningen 2018. reviewed 263 papers form statements invited 30 HCPs from different disciplines geographical locations; 28...
To study neo-aortic growth and the evolution of valve regurgitation (AR) in patients with transposition great arteries (TGA) after arterial switch operation (ASO) from newborn to adulthood identify at risk.Neo-aortic dimensions (annulus/root/sinotubular junction) were assessed serially 345 TGA who underwent ASO between 1977 2015. Linear mixed-effect models used assess increase over time risk factors for dilatation. Risk factor analysis AR by using time-dependent Cox regression models.After a...
The objective of this study was to assess our 43-year experience with arterial switch operation (ASO) for transposition the great arteries (TGA) by analysing cardiac outcome measures (hospital and late mortality, reoperations catheter interventions, significant coronary artery obstruction) identify risk factors reoperation interventions.A total 490 patients who underwent ASO TGA from 1977 2020 were included in retrospective, single-centre study. Data on intervention hospital survivors...
Both plasma low-density lipoprotein (LDL) cholesterol levels and risk for premature cardiovascular disease are extremely elevated in patients with homozygous familial hypercholesterolemia (HoFH), despite the use of multiple lowering treatments. Given its inborn nature, atherosclerotic plaques commonly observed young HoFH patients. Whether intensive lipid strategies result plaque regression adolescent is unknown.Two null/null LDLR variants, who participated R1500-CL-1629 randomized clinical...
Background— Kawasaki disease (KD) is the most common cause of acquired coronary artery in childhood. In KD, American Heart Association recommends echocardiography for routine surveillance and nuclear perfusion scans conventional angiography select patients. Cardiac MRI (CMRI) may be a noninvasive radiation-free alternative. We applied CMRI during follow-up patients with KD assessed performance compared echocardiography. Methods Results— Patients aged ≥8 years were consecutively included....
The aim of this study was to evaluate the incidence, disease presentation, treatment and cardiac outcome Kawasaki (KD) in Netherlands.The national Dutch Pediatric Surveillance Unit used prospectively register new KD cases from 2008 through 2012. Questionnaires were sent pediatricians obtain clinical information.Nationwide 341 reported during 5-year period, which 319 questionnaires (93.0%) returned. mean incidence estimated be 5.8/100,000 children <5 years age. median age at onset 2.4 (range...
Background Patients who have undergone the Fontan procedure are at high risk of circulatory failure. In an exploratory analysis we aimed to determine prognostic value blood biomarkers in a young cohort procedure. Methods and Results multicenter prospective studies patients underwent sampling, cardiopulmonary exercise testing, stress cardiac magnetic resonance imaging. Several including NT-proBNP (N-terminal pro-B-type natriuretic peptide), GDF-15 (growth differentiation factor 15), Gal-3...
Abstract Background: Passive leg raising is used to predict who will benefit from fluid therapy in critically ill patients, including children. Patients with a Fontan circulation may have different haemodynamic response challenge by passive raising. Methods: The of 31 paediatric patients the outpatient clinic (median age 14.0 years) and 35 healthy controls 12.8 was evaluated non-invasively echocardiography for assessment of, e.g., velocity time integral across (neo)aortic valve, blood...
Summary Kawasaki disease (KD) is an acute febrile syndrome of childhood, characterized by vasculitis the medium-sized arteries. White blood cell counts and inflammatory parameter C-reactive protein (CRP) are known to be elevated in phase disease. In this study we investigated course type-specific parameters KD over a longer period time. Plasma levels human neutrophil elastase (HNE), matrix metalloproteinases-2 -9 (MMP2, MMP9), gelatinase-associated lipocalin (NGAL), macrophage neopterin CRP...
Kawasaki disease (KD) is a paediatric vasculitis with coronary artery aneurysms (CAA) as its main complication. Two guidelines exist regarding the follow-up of patients after KD, by American Heart Association and Japanese Circulation Society. After acute phase, CAA-negative are checked for cardiovascular risk assessment or ECG echocardiography until 5 years disease. In CAA-positive patients, monitoring includes myocardial perfusion imaging, conventional angiography CT-angiography. However,...
Kawasaki disease (KD) is a vasculitis with formation of coronary artery aneurysms (CAAs) that can lead to myocardial ischemia. Echocardiography the primary imaging modality for arteries despite limited visualization. Coronary angiography (CAG) gold standard yet invasive high-radiation exposure. To date however, state-of-the-art CT scanners enable high-quality low-dose computed tomographic (cCTA) imaging. The aim our study in KD report (i) diagnostic yield cCTA compared echocardiography, and...
Abstract In patients with congenital heart disease (CHD), reduced exercise capacity can be a predictor for late complications and may used to guide interventions. Yet, the interpretation of is challenged by changes in body composition during growth. Our aim was create an overview disease-specific children CHD. We performed multicentre retrospective study CHD patients, aged 6–18 years, tested between January 2001 October 2018. Sex-specific distribution graphs were made using LMS method height...
Children with SARS-CoV-2 related Multisystem Inflammatory Syndrome in (MIS-C) often present clinical features that resemble Kawasaki disease (KD). Disease severity adult COVID-19 is associated to the presence of anti-cytokine autoantibodies (ACAAs) against type I interferons. Similarly, ACAAs may be implicated KD and MIS-C. Therefore, we explored immunological response, correlates both disorders.Eighteen inflammatory plasma protein levels seven were measured (n = 216) MIS-C 56)...
Although histopathologic studies suggest persistent myocardial abnormalities after Kawasaki disease (KD), the long-term effects on cardiac function remain to be revealed. We investigated biventricular volumes, function, and presence of fibrosis by magnetic resonance imaging during follow-up KD.Sixty patients with a history KD (mean age, 16.9 years; 67% men; median interval onset, 11.6 years) 20 healthy control subjects 17.9 55% men) 12 24 years age underwent imaging. Biventricular...
Background: Kawasaki disease (KD) is an acute vasculitis that mainly affects the coronary arteries. This inflammation can cause artery aneurysms (CAAs). Patients with KD need cardiac assessment for risk stratification development of myocardial ischemia, based on Z-score (luminal diameter corrected body surface area). Echocardiography primary imaging modality in but has several important limitations. Coronary computed tomographic angiography (cCTA) and Cardiac MRI (CMR) are non-invasive...
Abstract Objective To investigate whether common genetic variants in the vascular endothelial growth factor (VEGF) gene are associated with Kawasaki disease (KD) and subsequent development of coronary artery lesions. Methods Common VEGF were analyzed an association study a Dutch cohort 170 KD patients 300 healthy Caucasian controls. Genotyping was done 5′‐nuclease TaqMan assays 3′‐hybridization–triggered fluorescence minor groove binder Eclipse assays. Results An susceptibility to observed 2...
Summary Kawasaki disease (KD) is an acute vasculitis occurring in young children. Its aetiology unknown, but infectious agent assumed. Increased levels of proinflammatory cytokines and chemokines have been reported KD. Genetic variation these genes the receptors for could influence regulation chemokines. In a case–control study 170 Dutch Caucasian KD patients 300 healthy controls, common genetic variants chemokine receptor CCR3, CCR2, CCR5, CX3CR1, CXCR1 CXCR2 were analysed. Of eight studied...