A5051386254- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- Immunodeficiency and Autoimmune Disorders
- Diabetes and associated disorders
- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Organ Transplantation Techniques and Outcomes
- Multiple Sclerosis Research Studies
- HIV Research and Treatment
- Systemic Lupus Erythematosus Research
- Myasthenia Gravis and Thymoma
- vaccines and immunoinformatics approaches
- Complement system in diseases
- Inflammatory Myopathies and Dermatomyositis
- Drug-Induced Adverse Reactions
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Venous Thromboembolism Diagnosis and Management
- Ultrasound in Clinical Applications
- Psoriasis: Treatment and Pathogenesis
- Ultrasound and Hyperthermia Applications
Stockholm South General Hospital
2025
Karolinska Institutet
2024-2025
KTH Royal Institute of Technology
2020-2025
Science for Life Laboratory
2025
Nordic Bioscience (Denmark)
2023
Royal Perth Hospital
2005-2014
The University of Western Australia
2005-2014
Uppsala University Hospital
2014
Murdoch University
2004-2012
Fremantle Hospital
2012
Antigen-specific T cell immunity is HLA-restricted. Human immunodeficiency virus–type 1 (HIV-1) mutations that allow escape from host immune responses may therefore be HLA allele–specific. We analyzed HIV-1 reverse transcriptase sequences a large HLA-diverse population of HIV-1–infected individuals. Polymorphisms in were most evident at sites least functional or structural constraint and frequently associated with particular class I alleles. Absence polymorphism was also At level, the degree...
Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems have strong genetic component. We previously shown that the presence of HLA-B * 5701 strongly predicts and identified potential susceptibility locus within 300-kb region between MEGT1 C4A6 loci in central MHC. now report results fine recombinant mapping an expanded patient population 248 consecutive, fully ascertained, abacavir-exposed individuals Western Australian HIV Cohort Study,...
Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort. Cases involving combinations of hepatitis, fever or rash associated with an interaction between HLA-DRB1*0101 the percentage CD4, whereas no associations detected isolated rash. These data suggest that CD4 status may determine susceptibility to hypersensitivity, consistent T-cell-dependent immune response nevirapine-specific antigens.
We have used the term supratype to describe combinations of alleles and examined associations with disease. In RA insulin-dependent diabetes one or more supratypes appear be important but their functional significance remains obscure. MG SLE HLA may contain loci involved in immunoregulation, complement synthesis hormone metabolism. induced by D-Pen is associated Bw35/DR1 rather than A1, B8, DR3. contrast there no evidence a AS. proposed model for pathogenesis sacroiliitis AS postulated two...
Recurrent malignancy remains a significant complication after allogeneic hematopoietic cell transplantation (HCT). Efforts to decrease relapse have included donor lymphocyte infusion stimulate anti-recipient T-cell allorecognition of major and minor histocompatibility differences. Recently, alloreactive effects natural killer cell-mediated inhibitory immunoglobulin-like receptor (KIR) recognition recipient HLA-C -B ligands been described. We examined KIR ligand on risk in 1770 patients...
Abstract Objectives To develop and test the performance of computerized ultrasound image analysis using deep neural networks (DNNs) in discriminating between benign malignant ovarian tumors to compare its diagnostic accuracy with that subjective assessment (SA) by an expert. Methods We included 3077 (grayscale, n = 1927; power Doppler, 1150) images from 758 women tumors, who were classified prospectively expert examiners according IOTA (International Ovarian Tumor Analysis) terms...
The killer cell immunoglobulin-like receptors (KIR) are a family of expressed on natural (NK) cells and some T cells. Class I HLA molecules target the ligands for KIR receptors. number genes has been reported to vary between individuals, resulting in different haplotypes. There is little published data frequency each gene linkage disequilibrium genes. Because there evidence that NK may be involved bone marrow transplant rejection, we have determined frequencies possible haplotypic...
Abstract: HLA allele mismatches will provoke T‐cell alloreactivity after allogeneic stem cell transplantation. As donors and recipients are usually matched, the public epitopes that recognized by natural killer (NK) cells (NK epitopes) rarely mismatched, therefore there is potential for NK arising from absence of ligands inhibitory immunoglobulin‐like receptors ( KIR ). Transplants using related sharing only one haplotype (haploidentical donors) represent a setting in which often thus...
Abstract The expression and function of the NK cell receptor KIR2DL4 are controversial. Two common alleles transmembrane domain exist. 10A allele with 10 adenines at end exon encodes a full length receptor, whereas 9A has only 9 resulting in frame shift which turn generates stop codon early first cytoplasmic exon. possibility that might result differences was explored using mAbs to KIR2DL4. Transfection experiments cDNA from revealed significant membrane protein encoded by allele. Analysis...
Abstract: Immunogenetic factors are important in systemic lupus erythematosus (SLE) and deficiency of a number complement components is often associated with lupuslike illness. The Bf, C2 C4 encoded within the human major histocompatibility complex (MHC) polymorphic. A study HLA Bf polymorphism 43 patients SLE was undertaken firstly, to determine whether partial may predispose disease secondly, because it allow better definition supratypes which include relevant gene(s). An increased...
Allogeneic hematopoietic stem cell transplant (HSCT) recipients were assessed to elucidate memory B defects underlying their increased susceptibility infections, particularly by encapsulated bacteria. Circulating IgM cells (CD19<sup>+</sup>, CD27<sup>+</sup>, IgM<sup>+</sup>) and switched IgM<sup>−</sup>) enumerated in allogeneic HSCT (n = 37) healthy controls 35). T lymphocyte subpopulations serum levels of immunoglobulins, including IgG subclasses, antibodies pneumococcal polysaccharides...