A5046897720- Ovarian cancer diagnosis and treatment
- Ovarian function and disorders
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Ultrasound and Hyperthermia Applications
- Neuroendocrine Tumor Research Advances
- Uterine Myomas and Treatments
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- Cardiovascular Disease and Adiposity
- Asthma and respiratory diseases
- Intraperitoneal and Appendiceal Malignancies
- Cardiovascular Health and Disease Prevention
- Cancer Research and Treatments
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Ultrasound Imaging and Elastography
- Circadian rhythm and melatonin
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Ectopic Pregnancy Diagnosis and Management
- Growth Hormone and Insulin-like Growth Factors
Medical University of Silesia
2016-2025
University of California, Berkeley
2019-2021
Kelowna General Hospital
2020
University of California, Riverside
2016
University of Silesia in Katowice
2009-2012
University of Warsaw
1979-2011
Universidad de Navarra
2009-2010
New York University
2008
Lund University
2002
Small-cell lung cancer (SCLC) has been treated clinically as a homogeneous disease, but recent discoveries suggest that SCLC is heterogeneous. Whether metabolic differences exist among subtypes largely unexplored. In this study, we aimed to determine whether vulnerabilities between can be therapeutically exploited.We performed steady state metabolomics on tumors isolated from distinct genetically engineered mouse models (GEMM) representing the MYC- and MYCL-driven of SCLC. Using genetic...
Abstract Objective To evaluate the performance of diagnostic prediction models for ovarian malignancy in all patients with an mass managed surgically or conservatively. Design Multicentre cohort study. Setting 36 oncology referral centres (tertiary a specific gynaecological unit) other types centre. Participants Consecutive adult presenting adnexal between January 2012 and March 2015 by surgery follow-up. Main outcome measures Overall centre discrimination, calibration, clinical utility six...
To describe the ultrasound features of different endometrial and other intracavitary pathologies inpre- postmenopausal women presenting with abnormal uterine bleeding, using International Endometrial Tumor Analysis (IETA) terminology.This was a prospective observational multicenter study consecutive bleeding. Unenhanced sonography color Doppler fluid-instillation were performed. sampling performed according to each center's local protocol. The histological endpoints cancer, atypical...
ABSTRACT Objective Previous work has suggested that the ultrasound‐based benign simple descriptors (BDs) can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. This study aimed to validate modified version BDs and two‐step strategy estimate risk malignancy, which are followed by Assessment Different NEoplasias adneXa (ADNEX) model if do not apply. Methods was retrospective analysis using data from 2‐year interim International Ovarian Tumor Analysis...
Importance Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk malignancy categories with either O-RADS lexicon, proposed by American College Radiology, or International Ovarian Tumor Analysis (IOTA) 2-step strategy. Objective To investigate diagnostic performance lexicon IOTA Design, Setting, Participants Retrospective external validation study based on interim data IOTA5, a...
Pentatricopeptide repeat (PPR) proteins are the largest known RNA-binding protein family, and found in all eukaryotes, being particularly abundant higher plants. PPR localize mostly to mitochondria chloroplasts, many were shown modulate organellar genome expression on posttranscriptional level. Although genomes of land plants encode hundreds proteins, only a few have been identified Fungi Metazoa. As current motif profiles built mainly basis predominant plant sequences, they unlikely be...
The physiological significance and metabolism of oligoadenylated polyadenylated human mitochondrial mRNAs are not known to date. After study eight transcripts (ND1, ND2, ND3, ND5, CO1, CO2, ATP6/8 Cyt. b) we found a direct correlation between the half-lives their steady-state levels. Investigation mt-mRNA decay after thiamphenicol treatment indicated that three (ND2, ND3 significantly stabilized inhibition translation. Careful analysis one them, showed inaccurate processing H-strand RNA...
Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role translation initiation early induction specific genes remains unclear. Here, we show human factor eIF3 interacts with select immune system related mRNAs including those encoding cell receptor (TCR) subunits TCRA and TCRB. Binding to
The human testis has almost as high a frequency of alternative splicing events brain. While not extensively studied brain, few candidate testis-specific regulator proteins have been identified, including the nuclear RNA binding RBMY and hnRNP G-T, which are germ cell-specific versions somatically expressed G protein highly conserved in mammals. activator Tra2beta is also physically interacts with these family proteins. In this study, we identified novel cassette exon TLE4-T within intron 6...
Abstract Objective To assess whether, when using spherical sampling with Virtual Organ Computer‐Aided Analysis (VOCAL™) for calculating three‐dimensional (3D) power Doppler angiography (PDA) indices, the sphere volume affects performance in prediction of malignancy vascularized cystic‐solid or solid adnexal masses. Methods One hundred and thirty‐eight women (mean ± SD age, 51.8 14.1 years) diagnosed as having masses on B‐mode two‐dimensional (2D) ultrasound were evaluated by 3D‐PDA prior to...
Abstract Objective To compare spatiotemporal image correlation–high definition flow (STIC‐HDF) indices from spherical samples of ovary between women with polycystic syndrome (PCOS) and normal women. Methods This was a prospective case–control study premenopausal diagnosis PCOS according to the Rotterdam criteria healthy, regularly menstruating, (controls) matched for age (< 35 years) body mass index. Women were assessed in follicular phase menstrual cycle by 4D STIC‐HDF transvaginal...
The aim of the study was to see if there are any correlations between changes in endocrine system and clinical condition asthmatic patients ,in particular their lung function ,caused by hormone replacement therapy (HRT). Fifty-five 20 healthy postmenopausal women (aged 48–60) were studied before HRT after 6 months cyclical transdermal 17β-estradiol medroxyprogesterone acetate treatment. Serum estradiol ,cortisol dehydroepiandrosterone sulfate (DHEAS) concentrations assessed with use RIA ,and...
Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience three scientific societies, we present contemporary recommendations concerning PCOS diagnostics treatment. In adult female diagnosis, use Rotterdam criteria, which is two out follwing characteristics: a) ovulation abnormality, b) clinical or biochemical hyperandrogenism, c) polycystic ovaries. case teenagers, diagnostic criteria are...
Objectives To assess whether strain elastography may be used to visualize the different stiffness of endometrial polyps and submucosal fibroids. Methods We conducted a prospective monocentric single‐operator study on diagnostic accuracy. Patients who qualified for hysteroscopy because suspected fibroids were included. Before procedure, all patients underwent routine sonographic power Doppler examinations. Additionally, intrauterine lesions was assessed by elastography. The enhancement...
Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration basic FSH secretion in postmenopausal asthmatic women, before after HRT use, to identify any connections between changes hormone concentrations patients' clinical state.Postmenopausal women (55 20 healthy, aged 48-60 years).Serum was assessed by radioimmunoassay 6 months transdermal 17beta-E2 medroxyprogesterone acetate treatment (cyclical method). Intensification menopausal symptoms Kupperman's index.Secretion...
Objective The purpose of this study was to evaluate the usefulness virtual spherical tissue sampling using 3-dimensional (3D) ultrasound power Doppler angiography enhance differentiation between normal and pathologic ovaries. Methods Twenty-seven cases with ovarian tumors were analyzed: 14 invasive cancers 13 borderline confirmed by surgery. control subjects consisted 53 healthy ovulating women. Ultrasound scans done, 3D volumes analyzed 3-/4-dimensional software for personal computers based...
The purpose of this study was to describe a new method for assessing ovarian vascularization using spatiotemporal image correlation (STIC)-high-definition flow (HDF).Thirty healthy premenopausal fertile women were assessed in the follicular part menstrual cycle by transvaginal sonography. A 4-dimensional STIC-HDF volume obtained from nondominant ovary assess 3-dimensional (3D) vascular indices (vascularization index [VI] and [FI]) during one cardiac each women. Using 1-cm(3) spherical...
Females with polycystic ovary syndrome (PCOS) are characterized by several metabolic abnormalities that favor the development of atherosclerosis. Atherosclerosis is possibly a chronic inflammatory process, and markers state, such as C-reactive protein (CRP) fibrinogen may be useful to assess global risk developing cardiovascular diseases. These proteins might helpful in finding females subclinical The purpose this study was serum CRP concentrations young PCOS clarify possible correlations...