Alan A. Arslan
A5025163038- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Endoplasmic Reticulum Stress and Disease
- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Endometrial and Cervical Cancer Treatments
- Cancer, Lipids, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Pancreatitis Pathology and Treatment
- Ovarian function and disorders
- Cancer Genomics and Diagnostics
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Injury Epidemiology and Prevention
- Endometriosis Research and Treatment
- RNA modifications and cancer
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Reproductive Biology and Fertility
- Folate and B Vitamins Research
New York University
2015-2024
NYU Langone Health
2003-2024
Klinikum Stuttgart
2024
Population Council
2021-2022
New York City Health and Hospitals Corporation
2021-2022
Columbia University Irving Medical Center
2004-2021
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2020
National Cancer Institute
2010-2016
Brigham and Women's Hospital
2010-2016
Cancer Genetics (United States)
2015
An understanding of the etiologic heterogeneity ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, lifestyle factors by histologic subtype in Ovarian Cancer Cohort Consortium (OC3).
Obesity has been proposed as a risk factor for pancreatic cancer.
Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association smoking intensity, duration, and cumulative dose with cancer limited. The authors analyzed pooled data from international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios 95% confidence intervals were calculated by using unconditional logistic regression. intensity effects examined excess odds ratio model that was linear in...
Insulin-like growth factor I (IGF-I) is a systemic hormone with potent mitogenic and anti-apoptotic properties, which could influence the proliferative behavior of normal breast cells. Limited epidemiological observations suggest that may play role in etiology cancer, especially at pre-menopausal ages. In prospective case-control study nested within cohort New York City women, IGF-I, IGF-binding protein 3 (IGFBP-3) C peptide were measured frozen serum samples from 172 115 post-menopausal...
OBJECTIVE: Excess weight has been associated with increased risk of cancer at several organ sites. In part, this effect may be modulated through alterations in the metabolism sex steroids and IGF-I related peptides. The objectives study were to examine association body mass index (BMI) circulating androgens (testosterone, androstenedione dehydroepiandrosterone sulfate (DHEAS)), estrogens (estrone estradiol), hormone-binding globulin (SHBG), IGF-binding protein (IGFBP)-3, relationship between...
Late or early menopause has been implicated in risk of several chronic diseases women. To study factors influencing the onset natural menopause, authors analyzed follow-up data 4694 premenopausal women who enrolled New York University Women Study at ages 34-61. In an average 5.4 years observation, there were 2035 incidences with median age 51.3 years. Current smokers experienced 0.75 earlier than never-smokers. Those smoked more 10 cigarettes per day had a 40% increase menopause. contrast,...
Abstract The relation between diet and female colorectal cancer was analyzed in a prospective study of 14,727 women aged 34–65 years, who were enrolled at mammographie screening clinics New York Florida from 1985 to 1991. They followed through the end 1994 (average 7.1 yrs) by combination direct contact mail telephone record linkages with regional tumor registries, resulting 100 incident cases cancer. There no overall positive or inverse association risk intakes total calories, subclasses...
Abstract A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but influence specific genotypes remains unknown. We determined (OO, AO, AA, AB, BO, and BB) in 1,534 cases 1,583 controls from 12 prospective cohorts PanScan, grouping participants by genotype-derived serologic blood type (O, A, B). Adjusted odds ratios (ORs) for cancer alleles were calculated using logistic regression. Compared O, ORs subjects...
Abstract Experimental and epidemiological data support a role for sex steroid hormones in the pathogenesis of endometrial cancer. The associations pre‐diagnostic blood concentrations estradiol, estrone, testosterone, androstenedione, DHEAS SHBG with cancer risk were investigated. A case‐control study was nested within 3 cohorts New York (USA), Umeå (Sweden) Milan (Italy). Cases 124 postmenopausal women invasive For each case, 2 controls selected, matching case on cohort, age date...
Accumulating evidence suggests that folate, which is plentiful in vegetables and fruits, may be protective against colorectal cancer. The authors have studied the relationship of baseline levels serum folate homocysteine to subsequent risk cancer a nested case–control study including 105 cases 523 matched controls from New York University Women's Health Study cohort. In univariate analyses, had lower higher than controls. difference was more significant for (P < 0.001) = 0.04). After...
We assessed the association of sex hormone levels with breast cancer risk in a case–control study nested within cohort 7054 New York University (NYU) Women's Health Study participants who were postmenopausal at entry. The includes 297 cases diagnosed between 6 months and 12.7 years after enrollment 563 controls. Multivariate odds ratios (ORs) (95% confidence interval (CI)) for highest quintile each sex-hormone binding globulin (SHBG) relative to lowest as follows: 2.49 (1.47–4.21),...
Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin (25(OH)D) concentrations (the best indicator of derived diet sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study participants 8 cohorts within Cohort Consortium Vitamin Pooling Project Rarer Cancers (VDPP) (1974–2006) to evaluate whether prediagnostic circulating 25(OH)D were associated with development cancer. In total, 952 incident...
Studies of related individuals have consistently demonstrated notable familial aggregation cancer. We aim to estimate the heritability and genetic correlation attributable additive effects common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
A family history of pancreatic cancer has consistently been associated with increased risk cancer. However, uncertainty remains about the strength this association. Results from previous studies suggest a select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, We examined association between 5 types (pancreas, prostate, using data collaborative nested case-control study conducted by Pancreatic Cancer Cohort Consortium. Cases controls were...