Yolanda Benavente
A5103019306- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- Carcinogens and Genotoxicity Assessment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- Cancer Risks and Factors
- T-cell and Retrovirus Studies
- Polyomavirus and related diseases
- Nutritional Studies and Diet
- Occupational and environmental lung diseases
- Immunodeficiency and Autoimmune Disorders
- Genetic Associations and Epidemiology
- Air Quality and Health Impacts
- Hepatitis C virus research
- Pesticide Exposure and Toxicity
- RNA modifications and cancer
- Full-Duplex Wireless Communications
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- CNS Lymphoma Diagnosis and Treatment
Institut Català d'Oncologia
2016-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2015-2025
Institut d'Investigació Biomédica de Bellvitge
2015-2024
Instituto de Salud Carlos III
2021-2024
Institut Català d'Ornitologia
2006-2024
Universitat de Barcelona
2012-2023
Duran i Reynals Hospital
2013-2023
Centro de Investigación Biomédica en Red
2008-2022
Centre for Biomedical Network Research on Rare Diseases
2022
National Cancer Institute
2014-2021
Studies of related individuals have consistently demonstrated notable familial aggregation cancer. We aim to estimate the heritability and genetic correlation attributable additive effects common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation an independent replication series, to identify common genetic variants associated total subtypes defined EBV Multiple logistic regression was used calculate...
In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants added to previous data (patients diagnosed from 1989 2005 14 case-control studies; 7,999 cases, 8,452 controls) for testing of the TNF –308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10 –3575T>A (rs1800890, rs1800896),...
Chronic lymphocytic leukemia (CLL) and small lymphoma (SLL) are two subtypes of non-Hodgkin lymphoma. A number studies have evaluated associations between risk factors CLL/SLL risk. However, these remain inconsistent or lacked confirmation. This may be due, in part, to the inadequate sample size cases.We performed a pooled analysis 2440 cases 15186 controls from 13 case-control Europe, North America, Australia. We medical history, family lifestyle, occupational with Multivariate logistic...
Abstract Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis six genome-wide association studies, imputed using merged reference panel 1,000 Genomes and UK10K data, totalling 6,200 cases 17,598 controls after replication. We identify nine at 1p36.11 (rs34676223, P =5.04 × 10 −13 ), 1q42.13 (rs41271473, =1.06 −10 4q24 (rs71597109, =1.37 4q35.1 (rs57214277, =3.69 −8 6p21.31...
Personal use of hair dye has been inconsistently linked to risk non-Hodgkin lymphoma (NHL), perhaps because small samples or a lack detailed information on personal hair-dye in previous studies. This study included 4,461 NHL cases and 5,799 controls from the International Lymphoma Epidemiology Consortium 1988–2003. Increased (odds ratio (OR) = 1.3, 95% confidence interval (CI): 1.1, 1.4) associated with was observed among women who began using before 1980. Analyses by subtype showed...
The aim of the present study was to estimate prevalence Kaposi sarcoma-associated herpesvirus (KSHV) in female general population, define geographic variation and heterosexual transmission virus.The included 10,963 women from 9 countries for whom information on sociodemographic characteristics reproductive, sexual, smoking behaviors were available. Antibodies against KSHV that encoded lytic antigen K8.1 latent ORF73 determined.The range (defined as detection any antigen) 3.81%-46.02%, with...
<h3>Objectives</h3> We investigated the role of occupational exposure to specific groups agrochemicals in aetiology lymphoma overall, B cell and its most prevalent subtypes. <h3>Methods</h3> In 1998–2003, 2348 incident cases 2462 controls were recruited EPILYMPH case-control study six European countries. A detailed history was collected controls. Job modules applied for farm work including questions on type crop, size, pests being treated, schedule pesticide use. each centre, industrial...
Marginal zone lymphoma (MZL), comprised of nodal, extranodal, and splenic subtypes, accounts for 5%–10% non-Hodgkin cases. A detailed evaluation the independent effects risk factors MZL its subtypes has not been conducted. Data were pooled from 1052 cases (extranodal [EMZL] = 633, nodal [NMZL] 157, [SMZL] 140) 13766 controls 12 case–control studies. Adjusted unconditional logistic regression was used to compute odds ratios (ORs) 95% confidence intervals (CIs). Novel findings include...
Dermal neurofibromas (dNFs) are benign tumors of the peripheral nervous system typically associated with Neurofibromatosis type 1 (NF1) patients. Genes controlling integrity DNA likely to influence number developed because dNFs caused by somatic mutational inactivation NF1 gene, frequently evidenced loss heterozygosity (LOH). We performed a comprehensive analysis prevalence and mechanisms LOH in dNFs. Our study included 518 from 113 was detected 25% (N = 129). The most frequent mechanism...
Abstract Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS 1,281 MZL cases and 7,127 controls European ancestry identify two independent loci near BTNL2 (rs9461741, P =3.95 × 10 −15 ) HLA-B (rs2922994, =2.43 −9 in HLA region significantly associated with risk. This first evidence that genetic variation major histocompatibility complex influences susceptibility.
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk non-Hodgkin lymphoma (NHL). However, these may be biased by reverse causation, confounded unmeasured environmental exposures and might miss time points for which prospective measurement would best reveal relationship between NHL risk. We performed analysis genetically inferred study 10 102 cases the four most common B-cell histologic types 9562...