A5019414088- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Indigenous Studies and Ecology
- Ethics in Clinical Research
- Nutrition, Genetics, and Disease
- Cardiovascular Health and Risk Factors
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Race, Genetics, and Society
- Health disparities and outcomes
- Vitamin K Research Studies
- Pharmacogenetics and Drug Metabolism
University of Washington
2009-2024
Stanford University
1913-2024
Thomas Jefferson University
2022-2024
Fred Hutch Cancer Center
1991-2016
National Cancer Institute
2015
Cancer Genetics (United States)
2015
University College London
2000-2015
Seattle University
1997-2015
National Institutes of Health
1993-2015
National Institute of Nursing Research
2015
Despite nearly 40 years of research, the role plasma triglyceride as a risk factor for cardiovascular disease remains elusive. The objectives present study were to quantify magnitude association between and in general population, determine whether this relationship is independent high-density lipoprotein (HDL) cholesterol, using semi-quantitative techniques metaanalysis.Seventeen studies selected analysis based on published reports population-based, prospective studies, including 46413 men...
DNA vaccines have been demonstrated to be potent in small animals but are less effective primates. One limiting factor may inefficient uptake of by cells situ. In this study, we evaluated whether cellular was a significant barrier efficient transfection vivo and subsequent induction immune responses. For purpose, used the technique electroporation facilitate delivery vivo. This technology shown substantially increase cells, resulting increased expression elevated The potency weakly...
Segregation analysis of breast cancer in families can provide the logical basis and specific genetic models for mapping identifying genes responsible human cancer. Patterns occurrence were investigated by complex segregation analysis. In a sample 1579 nuclear ascertained through population-based series probands, an autosomal dominant model with highly penetrant susceptibility allele fully explained disease clustering. From maximum-likelihood Mendelian model, frequency was 0.0006 general...
The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study nonfatal myocardial infarction. Subclasses LDL were analyzed by gradient gel electrophoresis plasma samples from 109 cases and 121 controls. pattern characterized preponderance small, dense particles significantly associated threefold increased risk infarction, independent age, sex, relative weight. Plasma levels high-density cholesterol decreased,...
The differences in cardiovascular health status between participants and non-participants were examined In a population-based study. Telephone interviews with non-respondents revealed generally more disease but less hyperlipidemia family history of disease. Non-respondents did not differ regarding known hypertension, diet or drug therapy for hyperlipidemia, egg use. likely to be cigarette smokers. Because the amount non-respondent bias study was small while response rate high, respondents...
Background —The hypothesis that a family history of myocardial infarction (MI) or primary cardiac arrest (PCA) is an independent risk factor for was examined in population-based case-control study. In addition, we investigated whether recognized factors account the familial aggregation these cardiovascular events. Methods and Results —PCA cases, 25 to 74 years old, attended by paramedics during period 1988 1994 control subjects matched age sex were identified from community random digit...
GREAT progress has been made over the past 30 years in identifying cardiovascular risk factors and developing implementing measures to correct them. The Adult Treatment Panel of National Cholesterol Education Program developed guidelines 1988 that identified low-density lipoprotein (LDL) as major atherogenic high levels LDL cholesterol (LDL-C) primary target for cholesterol-lowering therapy. Since these were developed, scientific database significantly expanded. Genetic investigations into...
Although pancreatic cancer has an extremely high case fatality rate, little is known about differences in mortality by histologic types. We examined median survival and risk of for endocrine tumors two types exocrine tumors, adenocarcinomas, mucinous tumors.This analysis included 35,276 cases reported to the nine population-based registries participating Surveillance, Epidemiology, End Results program from 1973 2000. Survival among with were compared using Kaplan-Meier plots. Comparative...
The inheritance of low density lipoprotein (LDL) subclass patterns was investigated in 234 members seven large kindreds with familial combined hyperlipidemia (FCHL), a disorder characterized by elevated LDL cholesterol and/or triglyceride and increased coronary disease risk families. Analysis subclasses nondenaturing gradient gel electrophoresis showed predominance large, buoyant particles (pattern A) 71% the family small, dense B) 29% members. Based on complex segregation analysis, pattern...
Background —Familial combined hyperlipidemia (FCHL) and familial hypertriglyceridemia (FHTG) are 2 of the most common forms hyperlipidemia. There is a paucity prospective data concerning risk cardiovascular disease (CVD) in such families. The purposes this study were to estimate 20-year total CVD mortality among relatives these families evaluate plasma triglyceride as predictor death. Methods Results —The was based on lipid medical history from 101 ascertained studies conducted early 1970s....
Hepatic triglyceride lipase (HL) is thought to play a role in the formation of low density lipoproteins (LDLs) from small very (VLDLs) and intermediate (IDLs). To analyze possible physiological HL determining LDL buoyancy, size, chemical composition, activity were studied 21 patients with coronary artery disease (CAD) 23 normolipidemic subjects. In both groups, buoyancy size inversely associated levels. The effect on was comparable CAD appeared influence lipid composition primarily by...
Low-density lipoprotein (LDL) subclass phenotype B, characterized by predominance of small, dense LDL particles, is associated with elevated plasma triglycerides and apolipoprotein B lower high-density (HDL) cholesterol A-I. Because these abnormalities resemble the dyslipidemia insulin resistance, we examined associations levels other aspects resistance syndrome.LDL phenotypes were determined gradient gel electrophoresis in 682 female twins aged 30 to 91 years who participated second...
The contributions of shared genes and environments to familial aggregation coronary heart disease risk factors were investigated by genetic epidemiologic analysis 434 adult female twin pairs from the Kaiser-Permanente Twin Registry in Oakland, California, during 1978 1979. Initial estimates heritability statistically significant for serum levels high density lipoprotein (HDL) cholesterol, low (LDL) triglycerides, Quetelet index, but only marginally systolic diastolic blood pressures. These...
Studies of related individuals have consistently demonstrated notable familial aggregation cancer. We aim to estimate the heritability and genetic correlation attributable additive effects common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This harbors the TERT and CLPTM1L genes; former encodes catalytic subunit telomerase reverse transcriptase latter may play role in apoptosis. To investigate further genetic architecture common susceptibility this region, we conducted an agnostic subset-based meta-analysis (association analysis based subsets) across six 34 248 cases 45 036...
Background The excess risk of atherosclerosis among patients with non–insulin dependent diabetes mellitus (NIDDM) is well documented. However, the presence conventional factors cannot fully account for this risk, and underlying mechanism remains to be elucidated. present study prospectively evaluated role small LDL, a known factor coronary heart disease, as development NIDDM. Methods Results was based on nested case-control sample 204 elderly men women from Kuopio, Finland. LDL subclasses...
Multiple factors may determine insulin resistance and the syndrome The contributions of genes environment to distribution fasting levels associations with elements were evaluated in second examination Kaiser Permanente Women Twins Study (Oakland, California, 1989–1990). Subjects included 556 white women (165 monozygous twin pairs, 113 dizygous pairs; 455 normal glucose tolerance, 75 impaired 26 non-insulin-dependent diabetes by World Health Organization criteria). intraclass correlation...