A5073984505- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Renal cell carcinoma treatment
- Cancer Risks and Factors
- Gastric Cancer Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Gastroesophageal reflux and treatments
- Genetic Associations and Epidemiology
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Renal and related cancers
- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- Glutathione Transferases and Polymorphisms
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Nutrition, Genetics, and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Chronic Obstructive Pulmonary Disease (COPD) Research
Division of Cancer Epidemiology and Genetics
2008-2023
National Cancer Institute
2009-2023
Cancer Institute (WIA)
2005-2023
National Cancer Institute
2009-2023
The University of Texas MD Anderson Cancer Center
2013-2022
Wellcome Sanger Institute
2021
Institute of Electrical and Electronics Engineers
2020
National Institutes of Health
2008-2019
Shanghai Cancer Institute
2006-2016
Vanderbilt University
2006-2016
Obesity and hypertension have been implicated as risk factors for the development of renal-cell cancer.
Background. Incidence rates have risen rapidly for esophageal adenocarcinoma and moderately gastric cardia adenocarcinoma, while remained stable squamous cell carcinoma declined steadily noncardia adenocarcinoma. We examined anthropometric risk factors in a population-based casecontrol study of cancers Connecticut, New Jersey, western Washington. Methods: Healthy control subjects (n = 695) case patients with or 589) were frequency-matched to adenocarcinomas esophagus 554) by 5-year age...
Helicobacter pylori infection, now considered to be a cause of gastric cancer, is also strongly associated with and duodenal ulcer disease. The discovery these relations has brought the long-controversial connection between peptic ulcers cancer into focus.We estimated risk stomach in large cohort hospitalized patients or ulcers, as recorded Swedish Inpatient Register 1965 1983. Altogether, 57,936 were followed through 1989, for an average 9.1 years. standardized incidence ratio--the ratio...
Background: Incidence rates for adenocarcinomas of the esophagus and gastric cardia have risen steeply over last few decades. To determine risk factors these tumors, we conducted a multicenter, population-based, case-control study. Methods: The study included 554 subjects newly diagnosed with esophageal or adenocarcinomas, 589 squamous cell carcinoma other 695 control subjects. Estimates (odds ratios [ORs] corresponding 95% confidence intervals [CIs]) were calculated four tumor types...
Abstract Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation the von Hippel-Lindau (VHL) gene in cancer genome, unique to clear cell renal (ccRCC). Identify relationships between prevalence VHL alterations alteration subtypes with patient tumor characteristics. Experimental Design: As part large kidney case-control study conducted Central Europe, we analyzed mutations methylation 205 well-characterized, histologically confirmed biopsies...
Although cancer is a major cause of morbidity and mortality in most nations, the spectrum occurrence varies substantially worldwide. Most previous epidemiologic studies investigating etiology were conducted North American western European countries that are relatively homogenous terms spectrums many lifestyle exposures. These limitations may have hindered these from evaluating some important etiologic hypotheses. From 1996 to 2000, Shanghai Women's Health Study recruited 74,942 adult Chinese...
Previous studies that showed an association between smoking and adenocarcinomas of the esophagus esophagogastric junction were limited in their ability to assess differences by tumor site, sex, dose-response, duration cigarette cessation.We used primary data from 10 population-based case-control two cohort Barrett's Esophagus Esophageal Adenocarcinoma Consortium. Analyses restricted white non-Hispanic men women. Patients classified as having esophageal adenocarcinoma (n = 1540), junctional...
We analyzed renal cell cancer incidence patterns in the United States and reviewed recent epidemiologic evidence with regard to environmental host genetic determinants of risk. Renal rates continued rise among all racial/ethnic groups States, across age groups, for tumor sizes, most rapid increases localized stage disease small tumors. Recent cohort studies confirmed association smoking, excess body weight, hypertension an elevated risk cancer, suggested that these factors can be modified...
Previous studies suggest an association between obesity and oesophageal (OA) oesophagogastric junction adenocarcinomas (OGJA). However, these have been limited in their ability to assess whether the effects of vary by gender or presence gastro-oesophageal reflux (GERD) symptoms.
Calcium intake has been promoted because of its proposed benefit on bone health, particularly among the older population. However, concerns have raised about potential adverse effect high calcium cardiovascular health.
Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little known about whether this nutrient plays role in development or inhibition of cancer. To address gap knowledge, authors examined association between circulating 25-hydroxyvitamin (25(OH)D) cancer within large, nested case-control study developed as part Cohort Consortium Vitamin Pooling Project Rarer Cancers. Concentrations 25(OH)D were measured from 775 cases age-, sex-, race-,...
The effect of green tea drinking in reducing human cancer risk is unclear, though a protective has been reported numerous animal studies and several epidemiologic investigations. Herein the hypothesis that consumption may reduce cancers colon, rectum pancreas examined large population-based case-control study conducted Shanghai, China. Newly diagnosed cases (931 884 451 pancreas) during 1990-1993 among residents 30-74 years age were included. Controls (n = 1,552) selected Shanghai...
Stage at diagnosis was examined for various malignancies identifiable through screening to determine whether rural–urban differences exist in Georgia. Data were obtained from a population-based cancer registry which registers all incident cancers among residents of metropolitan Atlanta and ten neighboring rural counties. Black white patients with first primary invasive malignancy newly diagnosed between 1978 1985 included this study. Residents the area twice as likely have unstaged (18.3%)...
Genome-wide association studies of lung cancer reported in populations European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that achieved genome-wide significance with p-values 10−7 or lower. These been performed primarily cigarette smokers, raising the possibility observed associations could be related to tobacco use, carcinogenesis, both. Since most women Asia do not smoke, we conducted a study adenocarcinoma never-smoking females (584 cases, 585...