Federico Canzian

ORCID: 0000-0002-4261-4583
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Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Genetic Associations and Epidemiology
  • Liver Disease Diagnosis and Treatment
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • BRCA gene mutations in cancer
  • Endoplasmic Reticulum Stress and Disease
  • Genetic factors in colorectal cancer
  • Multiple Myeloma Research and Treatments
  • Nutrition, Genetics, and Disease
  • RNA modifications and cancer
  • Helicobacter pylori-related gastroenterology studies
  • Cancer Risks and Factors
  • Growth Hormone and Insulin-like Growth Factors
  • Telomeres, Telomerase, and Senescence
  • Pancreatitis Pathology and Treatment
  • Cancer, Lipids, and Metabolism
  • Bioinformatics and Genomic Networks
  • Cancer-related molecular mechanisms research
  • Neuroendocrine Tumor Research Advances
  • Molecular Biology Techniques and Applications
  • Pancreatic function and diabetes
  • Estrogen and related hormone effects
  • Lymphoma Diagnosis and Treatment
  • Genomics and Chromatin Dynamics

German Cancer Research Center
2016-2025

Heidelberg University
2015-2024

DKFZ-ZMBH Alliance
2006-2024

Center for Genomic Science
2010-2023

CTO Andrea Alesini
2023

National Cancer Institute
2010-2021

Casa Sollievo della Sofferenza
2020-2021

Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021

Division of Cancer Epidemiology and Genetics
2014-2021

Hellenic Health Foundation
2014-2018

Kyriaki Michailidou Sara Lindström Joe Dennis Jonathan Beesley Shirley Hui and 95 more Siddhartha Kar Audrey Lemaçon Penny Soucy Dylan M. Glubb Asha Rostamianfar Manjeet K. Bolla Qin Wang Jonathan P. Tyrer Ed Dicks Andrew Lee Zhaoming Wang Jamie Allen Renske Keeman Ursula Eilber Juliet D. French Xiaohong Chen Laura Fachal Karen McCue Amy E. McCart Reed Maya Ghoussaini Jason S. Carroll Xia Jiang Hilary K. Finucane Marcia Adams Muriel A. Adank Habibul Ahsan Kristiina Aittomäki Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Banu K. Arun Paul L. Auer François Bacot Myrto Barrdahl Caroline Baynes Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Paul Brennan Hermann Brenner Louise A. Brinton Per Broberg Ian W. Brock Annegien Broeks Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Katja Butterbach Qiuyin Cai Hui Cai Trinidad Caldés Federico Canzian Ángel Carracedo Brian D. Carter Jose E. Castelao Tsun Leung Chan Ting‐Yuan David Cheng Kee Seng Chia Ji‐Yeob Choi Hans Christiansen Christine L. Clarke Margriet Collée Don Conroy Emilie Cordina‐Duverger Sten Cornelissen David G. Cox Angela Cox Simon S. Cross Julie M. Cunningham Kamila Czene Mary B. Daly Peter Devilee Kimberly F. Doheny Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Mingajeva Elvira Christoph Engel

10.1038/nature24284 article EN Nature 2017-10-20

Genetic disorders that predispose people to colorectal cancer include the polyposis syndromes and hereditary nonpolyposis cancer. In contrast syndromes, lacks distinctive clinical features. However, a germ-line mutation of DNA mismatch-repair genes is characteristic molecular feature disease. Since screening carriers such mutations can help prevent cancer, it important devise strategies applicable for this

10.1056/nejm199805213382101 article EN New England Journal of Medicine 1998-05-21
Rosalind A. Eeles Ali Amin Al Olama Sara Benlloch Edward J. Saunders Daniel Leongamornlert and 95 more Malgorzata Tymrakiewicz Maya Ghoussaini Craig Luccarini Joe Dennis Sarah Jugurnauth-Little Tokhir Dadaev David E. Neal Freddie C. Hamdy Jenny Donovan Ken Muir Graham G. Giles Gianluca Severi Fredrik Wiklund Henrik Grönberg Christopher A. Haiman Fredrick R. Schumacher Brian E. Henderson Loı̈c Le Marchand Sara Lindstrӧm Peter Kraft David J. Hunter Susan M. Gapstur Stephen J. Chanock Sonja I. Berndt Demetrius Albanes Gerald L. Andriole Johanna Schleutker Maren Weischer Federico Canzian Elio Ríboli Timothy J. Key Ruth C. Travis Daniele Campa Sue A. Ingles Esther M. John Richard B. Hayes Paul D.P. Pharoah Nora Pashayan Kay‐Tee Khaw Janet L. Stanford Elaine A. Ostrander Lisa B. Signorello Stephen N. Thibodeau Dan Schaid Christiane Maier Walther Vogel Adam S. Kibel Cezary Cybulski Jan Lubiński Lisa Cannon‐Albright Hermann Brenner Jong Y. Park Radka Kaneva Jyotsna Batra Amanda B. Spurdle Judith A. Clements Manuel R. Teixeira Ed Dicks Andrew Lee Alison M. Dunning Caroline Baynes Don Conroy Melanie Maranian Shahana Ahmed Koveela Govindasami Michelle Guy Rosemary Wilkinson Emma Sawyer Angela Morgan David P. Dearnaley Alan Horwich Robert Huddart Vincent Khoo Christopher Parker Nicholas van As Christopher Woodhouse Alan Thompson Tim Dudderidge Chris Ogden Colin S. Cooper Artitaya Lophatananon Angela Cox Melissa C. Southey John L. Hopper Dallas R. English Markus Aly Jan Adolfsson Jiangfeng Xu Siqun L. Zheng Meredith Yeager Rudolf Kaaks W. Ryan Diver Mia M. Gaudet Mariana C. Stern Román Corral

10.1038/ng.2560 article EN Nature Genetics 2013-03-27
Nathaniel Rothman Montserrat García‐Closas Nilanjan Chatterjee Núria Malats Xifeng Wu and 95 more Jonine D. Figueroa Francisco X. Real David Van Den Berg Giuseppe Matullo Dalsu Baris Michael J. Thun Lambertus A. Kiemeney Paolo Vineis Immaculata De Vivo Demetrius Albanes Mark P. Purdue Þórunn Rafnar Michelle A.T. Hildebrandt Anne E. Kiltie Olivier Cussenot Klaus Golka Rajiv Kumar Jack A. Taylor José Mayordomo Kevin B. Jacobs Manolis Kogevinas Amy Hutchinson Zhaoming Wang Yi‐Ping Fu Ludmila Prokunina‐Olsson Laurie Burdett Meredith Yeager William Wheeler Adonina Tardón Consol Serra Alfredo Carrato Reina García-Closas Josep Lloreta Alison Johnson Molly Schwenn Margaret R. Karagas Alan R. Schned Gerald L. Andriole Robert L. Grubb Amanda Black Eric J. Jacobs W. Ryan Diver Susan M. Gapstur Stephanie J. Weinstein Jarmo Virtamo Victoria K. Cortessis Manuela Gago‐Dominguez Malcolm C. Pike Mariana C. Stern Jian‐Min Yuan David J. Hunter Monica McGrath Colin P. Dinney Bogdan Czerniak Meng Chen Hushan Yang Sita H. Vermeulen Katja K.H. Aben J.A. Witjes Remco R. Makkinje Patrick Sulem Søren Besenbacher Kári Stéfansson Elio Ríboli Paul Brennan Salvatore Panico Carmen Navarro Naomi E. Allen H. Bas Bueno-de-Mesquita Dimitrios Trichopoulos Neil E. Caporaso Maria Teresa Landi Federico Canzian Börje Ljungberg Anne Tjønneland Françoise Clavel‐Chapelon D. Timothy Bishop Mark Teo Margaret A. Knowles Simonetta Guarrera Silvia Polidoro Fulvio Ricceri Carlotta Sacerdote Alessandra Allione Géraldine Cancel‐Tassin Silvia Selinski Jan G. Hengstler H. Dietrich Tony Fletcher Péter Rudnai Eugen Gurzău Kvetoslava Koppová Sophia C.E. Bolick Ashley C. Godfrey Zongli Xu

10.1038/ng.687 article EN Nature Genetics 2010-10-24
Philip Haycock Stephen Burgess Aayah Nounu Jie Zheng George N. Okoli and 95 more Jack Bowden Kaitlin H. Wade Nicholas J. Timpson David M. Evans Peter Willeit Abraham Aviv Tom R. Gaunt Gibran Hemani Massimo Mangino Hayley Ellis Kathreena M. Kurian Karen A. Pooley Rosalind A. Eeles Jeffrey E. Lee Shenying Fang Wei V. Chen Matthew H. Law Lisa Bowdler Mark M. Iles Qiong Yang Bradford B. Worrall Hugh S. Markus Rayjean J. Hung Chris Amos Amanda B. Spurdle Deborah J. Thompson Tracy A. O’Mara Brian M. Wolpin Laufey T. Ámundadóttir Rachael Z. Stolzenberg‐Solomon Antonia Trichopoulou N. Charlotte Onland‐Moret Eiliv Lund Eric J. Duell Federico Canzian Gianluca Severi Kim Overvad Marc J. Gunter ­Rosario ­Tumino Ulrika Svenson André van Rij Annette F. Baas Matthew J. Bown Nilesh J. Samani Femke N.G. van t’Hof Gerard Tromp Gregory T. Jones Helena Kuivaniemi James R. Elmore Mattias Johansson James McKay Ghislaine Scélo Robert Carreras‐Torres Valérie Gaborieau Paul Brennan Paige M. Bracci Rachel Ε. Neale Sara H. Olson Steven Gallinger Donghui Li Gloria M. Petersen Harvey A. Risch Alison P. Klein Jiali Han Christian C. Abnet Neal D. Freedman Philip R. Taylor John M. Maris Katja K.H. Aben Lambertus A. Kiemeney Sita H. Vermeulen John K. Wiencke Kyle M. Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R. Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew‐Kee Low Krina T. Zondervan Grant W. Montgomery Dale R. Nyholt David A. van Heel Karen A. Hunt Dan E. Arking Foram N. Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand

The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.

10.1001/jamaoncol.2016.5945 article EN JAMA Oncology 2017-02-27

Lung cancer is a leading cause of mortality with an inter-individual difference in susceptibility to the disease. The inheritance low-efficiency genotypes involved DNA repair and replication may contribute susceptibility. We investigated 44 single nucleotide polymorphisms (SNPs) 20 genes including excision (NER) XPA , ERCC1 ERCC2/XPD ERCC4/XPF ERCC5/XPG; base (BER) APE1 / APEX OGG1 MPG XRCC1 PCNA POLB POLι LIG3 EXO1; double-strand break (DSB-R) XRCC2 XRCC3 XRCC9 NBS1 ATR; direct damage...

10.1093/carcin/bgi232 article EN Carcinogenesis 2005-09-29
Roger L. Milne Karoline Kuchenbaecker Kyriaki Michailidou Jonathan Beesley Siddhartha Kar and 95 more Sara Lindström Shirley Hui Audrey Lemaçon Penny Soucy Joe Dennis Xia Jiang Asha Rostamianfar Hilary K. Finucane Manjeet K. Bolla Lesley McGuffog Qin Wang Cora M. Aalfs Marcia Adams Julian Adlard Simona Agata Shahana Ahmed Habibul Ahsan Kristiina Aittomäki Fares Al‐Ejeh Jamie Allen Christine B. Ambrosone Christopher I. Amos Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Norbert Arnold Kristan J. Aronson Bernd Auber Paul L. Auer Margreet G.E.M. Ausems Jacopo Azzollini François Bacot Judith Balmañà Monica Barile Laure Barjhoux Rósa B. Barkardóttir Myrto Barrdahl Daniel R. Barnes Daniel Barrowdale Caroline Baynes Matthias W. Beckmann Javier Benı́tez Marina Bermisheva Leslie Bernstein Yves‐Jean Bignon Kathleen R. Blazer Marinus J. Blok Carl Blomqvist William J. Blot Kristie Bobolis Bram Boeckx Natalia Bogdanova Anders Bojesen Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Anikó Bozsik Angela R. Bradbury Judith S. Brand Hiltrud Brauch Hermann Brenner Brigitte Bressac–de Paillerets Carole Brewer Louise A. Brinton Per Broberg Angela Brooks‐Wilson Joan Brunet Thomas Brüning Barbara Burwinkel Saundra S. Buys Jinyoung Byun Qiuyin Cai Trinidad Caldés Maria A. Caligo Ian Campbell Federico Canzian Olivier Caron Ángel Carracedo Brian D. Carter Jose E. Castelao Laurent Castéra Virginie Caux‐Moncoutier Salina Chan Jenny Chang‐Claude Stephen J. Chanock Xiaohong Chen Ting‐Yuan David Cheng Jocelyne Chiquette Hans Christiansen Kathleen Claes Christine L. Clarke Thomas Conner Don Conroy Jackie Cook

10.1038/ng.3785 article EN Nature Genetics 2017-10-23

Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association smoking intensity, duration, and cumulative dose with cancer limited. The authors analyzed pooled data from international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios 95% confidence intervals were calculated by using unconditional logistic regression. intensity effects examined excess odds ratio model that was linear in...

10.1093/aje/kwp134 article EN American Journal of Epidemiology 2009-06-26
Christopher A. Haiman Gary K. Chen Celine M. Vachon Federico Canzian Alison M. Dunning and 95 more Robert C. Millikan Xianshu Wang Foluso O. Ademuyiwa Shahana Ahmed Christine B. Ambrosone Laura Baglietto Rosemary L. Balleine Elisa V. Bandera Matthias W. Beckmann Christine D. Berg Leslie Bernstein Carl Blomqvist William J. Blot Hiltrud Brauch Julie E. Buring Lisa A. Carey Jane Carpenter Jenny Chang‐Claude Stephen J. Chanock Daniel I. Chasman Christine L. Clarke Angela Cox Simon S. Cross Sandra L. Deming Robert B. Diasio Meletios Α. Dimopoulos W. Ryan Driver Thomas Dünnebier Lorraine Durcan Diana Eccles Christopher K. Edlund Arif B. Ekici Peter A. Fasching Heather Spencer Feigelson Dieter Flesch‐Janys Florentia Fostira Asta Försti George Fountzilas Susan M. Gerty Graham G. Giles Andrew K. Godwin Paul J. Goodfellow Nikki Graham Dario Greco Ute Hamann Susan E. Hankinson Arndt Hartmann Rebecca Hein Judith Heinz Andrea Holbrook Robert N. Hoover Jennifer J. Hu David J. Hunter Sue A. Ingles Astrid Irwanto Jennifer Ivanovich Esther M. John Nicola Johnson Arja Jukkola‐Vuorinen Rudolf Kaaks Yon‐Dschun Ko Laurence N. Kolonel Irene Konstantopoulou Veli-Matti Kosma Swati Kulkarni Diether Lambrechts Adam M. Lee Loı̈c Le Marchand Timothy G. Lesnick Jianjun Liu Sara Lindström Graham J. Mann Sara Margolin Nicholas G. Martin Penelope Miron Grant W. Montgomery Heli Nevanlinna Stephan Nickels Sarah J. Nyante Curtis Olswold Julie R. Palmer Harsh B. Pathak Dimitrios Pectasides Charles M. Perou Julian Peto Paul D.P. Pharoah Loreall Pooler Michael F. Press Katri Pylkäs Timothy R. Rebbeck Jorge L. Rodriguez‐Gil Lynn Rosenberg Eric A. Ross Thomas Rüdiger Isabel dos‐Santos‐Silva

10.1038/ng.985 article EN Nature Genetics 2011-10-30
Zsofia Kote‐Jarai Ali Amin Al Olama Graham G. Giles Gianluca Severi Johanna Schleutker and 95 more Maren Weischer Daniele Campa Elio Ríboli Timothy J. Key Henrik Grönberg David J. Hunter Peter Kraft Michael J. Thun Sue A. Ingles Stephen Chanock Demetrius Albanes Richard B. Hayes David E. Neal Freddie C. Hamdy Jenny Donovan Paul D.P. Pharoah Fredrick R. Schumacher Brian E. Henderson Janet L. Stanford Elaine A. Ostrander Karina D. Sørensen Thilo Dörk Gerald L. Andriole Joanne L. Dickinson Cezary Cybulski Jan Lubiński Amanda B. Spurdle Judith A. Clements Suzanne K. Chambers Joanne F. Aitken Robert A. Gardiner Stephen N. Thibodeau Dan Schaid Esther M. John Christiane Maier Walther Vogel Kathleen A. Cooney Jong Y. Park Lisa Cannon‐Albright Hermann Brenner Tomonori Habuchi Hongwei Zhang Yong‐Jie Lu Radka Kaneva Ken Muir Sara Benlloch Daniel Leongamornlert Edward J. Saunders Malgorzata Tymrakiewicz Nadiya Mahmud Michelle Guy Lynne T. O'Brien Rosemary Wilkinson Amanda L. Hall Emma J Sawyer Tokhir Dadaev Jonathan J. Morrison David P. Dearnaley A. Horwich Robert Huddart Vincent Khoo Christopher Parker Nicholas van As Christopher Woodhouse Alan Thompson Tim Christmas Chris Ogden Colin S. Cooper Aritaya Lophatonanon Melissa C. Southey John L. Hopper Dallas R. English Tiina Wahlfors Teuvo L.J. Tammela Peter Klarskov Børge G. Nordestgaard Martin Andreas Røder Anne Tybjærg‐Hansen Stig E. Bojesen Ruth C. Travis Federico Canzian Rudolf Kaaks Fredrik Wiklund Markus Aly Sara Lindström W. Ryan Diver Susan M. Gapstur Mariana C. Stern Román Corral Jarmo Virtamo Angela Cox Christopher A. Haiman Loı̈c Le Marchand Liesel M. FitzGerald Suzanne Kolb

10.1038/ng.882 article EN Nature Genetics 2011-07-10
Lang Wu Wei Shi Jirong Long Xingyi Guo Kyriaki Michailidou and 95 more Jonathan Beesley Manjeet K. Bolla Xiao‐Ou Shu Yingchang Lu Qiuyin Cai Fares Al‐Ejeh Esdy Rozali Qin Wang Joe Dennis Bingshan Li Chenjie Zeng Helian Feng Alexander Gusev Richard Barfield Irene L. Andrulis Hoda Anton‐Culver Volker Arndt Kristan J. Aronson Paul L. Auer Myrto Barrdahl Caroline Baynes Matthias W. Beckmann Javier Benı́tez Marina Bermisheva Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Hiltrud Brauch Hermann Brenner Louise A. Brinton Per Broberg Sara Y. Brucker Barbara Burwinkel Trinidad Caldés Federico Canzian Brian D. Carter Jose E. Castelao Jenny Chang‐Claude Xiaohong Chen Ting‐Yuan David Cheng Hans Christiansen Christine L. Clarke Margriet Collée Sten Cornelissen Fergus J. Couch David G. Cox Angela Cox Simon S. Cross Julie M. Cunningham Kamila Czene Mary B. Daly Peter Devilee Kimberly F. Doheny Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Miriam Dwek Diana Eccles Ursula Eilber A. Heather Eliassen Christoph Engel Mikael Eriksson Laura Fachal Peter A. Fasching Jonine D. Figueroa Dieter Flesch‐Janys Olivia Fletcher Henrik Flyger Lin Fritschi Marike Gabrielson Manuela Gago‐Dominguez Susan M. Gapstur Montserrat García‐Closas Mia M. Gaudet Maya Ghoussaini Graham G. Giles Mark S. Goldberg David E. Goldgar Anna González‐Neira Pascal Guénel Eric Hahnen Christopher A. Haiman Niclas Håkansson Per Hall Emily Hallberg Ute Hamann Patricia Harrington Alexander Hein Belynda Hicks Peter Hillemanns Antoinette Hollestelle Robert N. Hoover John L. Hopper Guanmengqian Huang Keith Humphreys

10.1038/s41588-018-0132-x article EN Nature Genetics 2018-06-18
Philip Law Maria Timofeeva Ceres Fernández‐Rozadilla Peter Broderick James B. Studd and 95 more Juan Fernández‐Tajes Susan M. Farrington Victoria Svinti Claire Palles Giulia Orlando Amit Sud Amy Holroyd Steven Penegar Evropi Τheodoratou P G Vaughan-Shaw Harry Campbell Lina Zgaga Caroline Hayward Archie Campbell Sarah E. Harris Ian J. Deary John M. Starr Laura Gatcombe Claudia M.A. Pinna Sarah Briggs Lynn Martin Emma Jaeger Archana Sharma‐Oates James E. East Simon J. Leedham Roland Arnold Elaine Johnstone Haitao Wang David Kerr Rachel Kerr Tim Maughan Richard Kaplan Nada Al Tassan Kimmo Palin Ulrika A. Hänninen Tatiana Cajuso Tomas Tanskanen Johanna Kondelin Eevi Kaasinen Antti‐Pekka Sarin Johan G. Eriksson Harri Rissanen Paul Knekt ­Eero Pukkala Pekka Jousilahti Veikko Salomaa Samuli Ripatti Aarno Palotie Laura Renkonen‐Sinisalo Anna Lepistö J. Böhm Jukka‐Pekka Mecklin Daniel D. Buchanan Aung Ko Win John L. Hopper Mark A. Jenkins Noralane M. Lindor Polly A. Newcomb Steven Gallinger David Duggan Graham Casey Per Hoffmann Markus M. Nöthen Karl‐Heinz Jöckel Douglas F. Easton Paul D.P. Pharoah Julian Peto Federico Canzian Anthony J. Swerdlow Rosalind A. Eeles Zsofia Kote‐Jarai Kenneth Muir Nora Pashayan Brian E. Henderson Christopher A. Haiman Fredrick R. Schumacher Ali Amin Al Olama Sara Benlloch Sonja I. Berndt David V. Conti Fredrik Wiklund Stephen J. Chanock Susan M. Gapstur Victoria L. Stevens Catherine M. Tangen Jyotsna Batra Judith A. Clements Henrik Grönberg Johanna Schleutker Demetrius Albanes Alicja Wolk Catharine West Lorelei A. Mucci Géraldine Cancel‐Tassin Stella Koutros

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has strong heritable basis. We report genome-wide association analysis 34,627 CRC cases 71,379 controls European ancestry that identifies SNPs at 31 new risk loci. also identify eight independent the previously reported loci, further nine loci only identified in Asian populations. use situ promoter capture Hi-C (CHi-C), gene expression, silico annotation methods to likely target genes SNPs. Whilst...

10.1038/s41467-019-09775-w article EN cc-by Nature Communications 2019-05-14
Laura Fachal Hugues Aschard Jonathan Beesley Daniel R. Barnes Jamie Allen and 95 more Siddhartha Kar Karen A. Pooley Joe Dennis Kyriaki Michailidou Constance Turman Penny Soucy Audrey Lemaçon Michael Lush Jonathan P. Tyrer Maya Ghoussaini Mahdi Moradi Marjaneh Xia Jiang Simona Agata Kristiina Aittomäki M. Rosario Alonso Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Aðalgeir Arason Volker Arndt Kristan J. Aronson Banu K. Arun Bernd Auber Paul L. Auer Jacopo Azzollini Judith Balmañà Rósa B. Barkardóttir Daniel Barrowdale Alicia Beeghly‐Fadiel Javier Benı́tez Marina Bermisheva Katarzyna Białkowska Amie Blanco Carl Blomqvist William J. Blot Natalia Bogdanova Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Åke Borg Kristin Bosse Hiltrud Brauch Hermann Brenner Ignacio Briceño Ian W. Brock Angela Brooks‐Wilson Thomas Brüning Barbara Burwinkel Saundra S. Buys Qiuyin Cai Trinidad Caldés Maria A. Caligo Nicola J. Camp Ian Campbell Federico Canzian Jason S. Carroll Brian D. Carter Jose E. Castelao Jocelyne Chiquette Hans Christiansen Wendy K. Chung Kathleen Claes Christine L. Clarke Margriet Collée Sten Cornelissen Fergus J. Couch Angela Cox Simon S. Cross Cezary Cybulski Kamila Czene Mary B. Daly Miguel de la Hoya Peter Devilee Orland Dı́ez Yuan Chun Ding Gillian S. Dite Susan M. Domchek Thilo Dörk Isabel dos‐Santos‐Silva Arnaud Droit Stéphane Dubois Martine Dumont M. Durán Lorraine Durcan Miriam Dwek Diana Eccles Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Olivia Fletcher Giuseppe Floris Henrik Flyger Lenka Foretová William D. Foulkes

10.1038/s41588-019-0537-1 article EN Nature Genetics 2020-01-01
Chen Li Svetlana Stoma Luca A. Lotta Sophie C. Warner Eva Albrecht and 91 more Alessandra Allione Pascal P. Arp Linda Broer Jessica L. Buxton Alexessander Couto Alves Joris Deelen Iryna O. Fedko Scott D. Gordon Tao Jiang Robert Karlsson Nicola D. Kerrison Taylor K. Loe Massimo Mangino Yuri Milaneschi Benjamin Miraglio Natalia Pervjakova Alessia Russo Ida Surakka Ashley van der Spek Josine E. Verhoeven Najaf Amin Marian Beekman Alexandra I. F. Blakemore Federico Canzian Stephen E. Hamby Jouke‐Jan Hottenga Peter D. Jones Jari Lahti Reedik Mägi Sarah E. Medland Grant W. Montgomery Dale R. Nyholt Markus Perola Kirsi H. Pietiläinen Veikko Salomaa Elina Sillanpää H. Eka D. Suchiman Diana van Heemst Gonneke Willemsen Antonio Agudo Heiner Boeing Dorret I. Boomsma María‐Dolores Chirlaque Guy Fagherazzi Pietro Ferrari Paul W. Franks Christian Gieger Johan G. Eriksson Marc J. Gunter Sara Hägg Iiris Hovatta Liher Imaz Jaakko Kaprio Rudolf Kaaks Timothy J. Key Vittorio Krogh Nicholas G. Martin Olle Melander Andres Metspalu Concha Moreno N. Charlotte Onland‐Moret Peter M. Nilsson Ken K. Ong Kim Overvad Domenico Palli Salvatore Panico Nancy L. Pedersen Brenda W.J.H. Penninx J. Ramón Quirós Marjo‐Riitta Järvelin Miguel Rodríguez‐Barranco Robert A. Scott Gianluca Severi P. Eline Slagboom Tim D. Spector Anne Tjønneland Antonia Trichopoulou ­Rosario ­Tumino André G. Uitterlinden Yvonne T. van der Schouw Cornelia M. van Duijn Elisabete Weiderpass Eros Lazzerini Denchi Giuseppe Matullo Adam S. Butterworth John Danesh Nilesh J. Samani Nicholas J. Wareham Christopher P. Nelson Claudia Langenberg Veryan Codd

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform genome-wide meta-analysis LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 regions at false dicovery rate (FDR) < 0.05 threshold prioritize genes 31, with five highlighting nucleotide metabolism as an important regulator LTL. report six significant loci in or near SENP7, MOB1B,...

10.1016/j.ajhg.2020.02.006 article EN cc-by The American Journal of Human Genetics 2020-02-27

Recent evidence indicate that small non-coding RNA molecules, called micro-RNAs (miRNAs), can bind to the 3′ untranslated regions (UTRs) of messenger RNAs and interfere with their translation, thereby regulating cell growth, differentiation, apoptosis tumorigenesis. Genetic polymorphisms reside on miRNA-binding sites. Thus, it is conceivable miRNA regulation may be affected by UTRs. Since gene deregulation one key mechanisms which cells progress cancer, we hypothesize common within...

10.1093/carcin/bgm304 article EN Carcinogenesis 2007-10-04

Abstract Objectives: We have undertaken a comprehensive study of common polymorphisms in genes DNA repair, exploring both the risk developing colorectal cancer and prognosis patients. Methods: Subjects from case-control (377 cases 329 controls) designed to assess gene-environment interactions were genotyped by use an oligonucleotide microarray arrayed primer extension technique. Twenty-eight single nucleotide 15 repair included. The candidate belong different pathways: base excision (OGG1,...

10.1158/1078-0432.ccr-05-1363 article EN Clinical Cancer Research 2006-04-01
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