Federico Canzian
- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Endoplasmic Reticulum Stress and Disease
- Genetic factors in colorectal cancer
- Multiple Myeloma Research and Treatments
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Cancer Risks and Factors
- Growth Hormone and Insulin-like Growth Factors
- Telomeres, Telomerase, and Senescence
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Molecular Biology Techniques and Applications
- Pancreatic function and diabetes
- Estrogen and related hormone effects
- Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
German Cancer Research Center
2016-2025
Heidelberg University
2015-2024
DKFZ-ZMBH Alliance
2006-2024
Center for Genomic Science
2010-2023
CTO Andrea Alesini
2023
National Cancer Institute
2010-2021
Casa Sollievo della Sofferenza
2020-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
Division of Cancer Epidemiology and Genetics
2014-2021
Hellenic Health Foundation
2014-2018
Genetic disorders that predispose people to colorectal cancer include the polyposis syndromes and hereditary nonpolyposis cancer. In contrast syndromes, lacks distinctive clinical features. However, a germ-line mutation of DNA mismatch-repair genes is characteristic molecular feature disease. Since screening carriers such mutations can help prevent cancer, it important devise strategies applicable for this
The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.
Lung cancer is a leading cause of mortality with an inter-individual difference in susceptibility to the disease. The inheritance low-efficiency genotypes involved DNA repair and replication may contribute susceptibility. We investigated 44 single nucleotide polymorphisms (SNPs) 20 genes including excision (NER) XPA , ERCC1 ERCC2/XPD ERCC4/XPF ERCC5/XPG; base (BER) APE1 / APEX OGG1 MPG XRCC1 PCNA POLB POLι LIG3 EXO1; double-strand break (DSB-R) XRCC2 XRCC3 XRCC9 NBS1 ATR; direct damage...
An improved model for risk stratification can be useful guiding public health strategies of breast cancer prevention.
Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association smoking intensity, duration, and cumulative dose with cancer limited. The authors analyzed pooled data from international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios 95% confidence intervals were calculated by using unconditional logistic regression. intensity effects examined excess odds ratio model that was linear in...
Abstract Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has strong heritable basis. We report genome-wide association analysis 34,627 CRC cases 71,379 controls European ancestry that identifies SNPs at 31 new risk loci. also identify eight independent the previously reported loci, further nine loci only identified in Asian populations. use situ promoter capture Hi-C (CHi-C), gene expression, silico annotation methods to likely target genes SNPs. Whilst...
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform genome-wide meta-analysis LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 regions at false dicovery rate (FDR) < 0.05 threshold prioritize genes 31, with five highlighting nucleotide metabolism as an important regulator LTL. report six significant loci in or near SENP7, MOB1B,...
Recent evidence indicate that small non-coding RNA molecules, called micro-RNAs (miRNAs), can bind to the 3′ untranslated regions (UTRs) of messenger RNAs and interfere with their translation, thereby regulating cell growth, differentiation, apoptosis tumorigenesis. Genetic polymorphisms reside on miRNA-binding sites. Thus, it is conceivable miRNA regulation may be affected by UTRs. Since gene deregulation one key mechanisms which cells progress cancer, we hypothesize common within...
Abstract Objectives: We have undertaken a comprehensive study of common polymorphisms in genes DNA repair, exploring both the risk developing colorectal cancer and prognosis patients. Methods: Subjects from case-control (377 cases 329 controls) designed to assess gene-environment interactions were genotyped by use an oligonucleotide microarray arrayed primer extension technique. Twenty-eight single nucleotide 15 repair included. The candidate belong different pathways: base excision (OGG1,...