A5075864700- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Ovarian cancer diagnosis and treatment
- Head and Neck Cancer Studies
- Acute Myeloid Leukemia Research
- Estrogen and related hormone effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Thyroid Cancer Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Oral Health Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
- Cholinesterase and Neurodegenerative Diseases
- Phytoestrogen effects and research
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Advanced Breast Cancer Therapies
- Acute Lymphoblastic Leukemia research
National Cancer Institute
2014-2024
National Institutes of Health
2011-2024
Division of Cancer Epidemiology and Genetics
2007-2023
United States Department of Health and Human Services
2019
Cooper Institute for Reproductive Hormonal Disorders
2019
Centre International de Recherche sur le Cancer
2017
Cancer Research Center
2017
German Cancer Research Center
2017
Heidelberg University
2017
Information Management Services
2017
Thyroid cancer incidence has increased substantially in the United States over last 4 decades, driven largely by increases papillary thyroid cancer. It is unclear whether increasing of been related to mortality trends.To compare trends and tumor characteristics at diagnosis.Trends incidence-based rates were evaluated using data from Surveillance, Epidemiology, End Results-9 (SEER-9) registry program, annual percent change was calculated log-linear regression.Tumor characteristics.Annual...
Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association cancer is not well understood.
Abstract Background: Age–period–cohort (APC) analysis can inform registry-based studies of cancer incidence and mortality, but concerns about statistical identifiability interpretability, as well the learning curves software packages, have limited its uptake. Methods: We implemented a panel easy-to-interpret estimable APC functions corresponding Wald tests in R code that be accessed through user-friendly Web tool. Results: Input data for tool consist age-specific numbers events person-years...
An improved model for risk stratification can be useful guiding public health strategies of breast cancer prevention.
Although preservation of the spleen following abdominal trauma and spleen-preserving surgical procedures have become gold standards, about 22,000 splenectomies are still conducted annually in USA. Infections, mostly by encapsulated organisms, most well-known complications splenectomy. Recently, thrombosis cancer recognized as potential adverse outcomes post-splenectomy. Among more than 4 million hospitalized USA veterans, we assessed incidence mortality due to infections, thromboembolism,...
Prostate cancer is a significant public health burden and major cause of morbidity mortality among men worldwide. Analyzing geographic patterns temporal trends may help identify high‐risk populations, suggest the degree PSA testing, provide clues to etiology. We used incidence data available from International Agency for Research on Cancer (IARC) certain registries 43 populations across five continents during median period 24 years. Trends in overall prostate rates showed distinct ranging...
BACKGROUND Lung cancer incidence rates overall are declining in the United States. This study investigated trends by histologic type and demographic characteristics. METHODS Surveillance, Epidemiology, End Results (SEER) program of microscopically confirmed lung squamous cell, small adenocarcinoma, large other, unspecified carcinomas among US whites blacks diagnosed from 1977 to 2010 white non‐Hispanics, Asian/Pacific Islanders, Hispanics 1992 were analyzed sex age. RESULTS Squamous cell...
Descriptive epidemiological information on myeloproliferative neoplasms (MPNs) and myelodysplastic (MDS)/MPNs is largely derived from single institution European population-based studies. Data obtained following adoption of the World Health Organization classification haematopoietic JAK2 V617F mutation testing are sparse. Using data, we comprehensively assessed subtype-specific MPN MDS/MPN incidence rates (IRs), IR ratios (IRRs) relative survival (RS) in United States (2001-12). IRs were...
The aetiology of marginal zone lymphoma (MZL) is purported to differ by anatomic site. While this supported clinical series single MZL sites, no population-based study has comprehensively assessed incidence patterns across sites. To gain insight into disease aetiology, we site using data from 18 U.S. Surveillance, Epidemiology and End Results (SEER) Program registries. We calculated age-adjusted rates (IRs) sex, race, calendar year. During 2001–2009, 4,081 (IR = 5·7/1,000,000 person-years)...
<b>Objective</b> In view of mobile phone exposure being classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC), we determined compatibility two recent reports glioma risk (forming basis IARC's classification) with observed incidence trends in United States. <b>Design</b> Comparison rates projected 1997-2008. We estimated combining relative risks reported 2010 Interphone study and 2011 Swedish Hardell colleagues adjusted age, registry, sex; data...
In a European cohort, it was previously reported that 35% of oropharyngeal cancer (OPC) patients were human papillomavirus type-16 (HPV16) seropositive up to 10 years before diagnosis vs 0.6% cancer-free controls. Here, we describe the kinetics HPV16-E6 antibodies prior OPC diagnosis.
This report describes an R package, called the Individualized Coherent Absolute Risk Estimator (iCARE) tool, that allows researchers to build and evaluate models for absolute risk apply them estimate individual’s of developing disease during a specified time interval based on set user defined input parameters. An attractive feature software is it gives users flexibility update rapidly new knowledge factors tailor different populations by specifying three arguments: model relative risk,...
To enhance understanding of etiology, we examined international population-based cancer incidence data for lymphoid leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma and myeloid leukemia among children aged 0-19. Based on temporal trends during 1978-2007 in 24 populations, rates generally have not changed greatly differences diminished some regions. Lymphoid 2003-2007 54 populations varied about 10-fold, with highest US white Hispanics (50.2 per million person-years) Ecuador (48.3) lowest...
Objective. To evaluate oral cavity and pharynx cancer (OCPC) patterns by gender. Methods. We used Surveillance, Epidemiology, End Results program data for 71,446 cases diagnosed during 1975-2008 to classify OCPC anatomic subsite as potentially HPV-related or not, with tongue considered a separate category. Results. Total rates among men were 2-4 times those women. Among whites, total rose in the younger age groups due substantial increases successive birth cohorts cancers, more rapid than...
Immune-mediated pathways have been recognized to be of importance in the pathogenesis chronic lymphocytic leukaemia (CLL). We assessed a broad variety immune-related and inflammatory conditions subsequent CLL development among 4 million adult male veterans admitted VA hospitals. identified 3,680 cases with up 27 years follow-up. Using Poisson regression analyses restricted or that occurred more than one year before CLL, we estimated relative risk (RR) 95% confidence intervals for risk....
To examine underlying etiologic factors that may explain the racial disparity in non-Hodgkin's lymphoma (NHL) incidence patterns.We assessed immune-related conditions and risk of developing NHL among more than 4 million hospitalized US veterans including 9,496 patients with (7,999 white 1,497 black patients) up to 26 years follow-up. We used time-dependent Poisson regression estimate rate ratios (RRs) 95% CIs for a history specific autoimmune diseases, infections, allergies compared without...
Background: Few well-established factors are associated with risk of amyotrophic lateral sclerosis (ALS). We comprehensively evaluate prescription drugs use in administrative health claims from U.S. Medicare beneficiaries relation to ALS generate hypotheses for further research. Methods: This is a population-based case–control study 10,450 participants (ages 66–89 years) diagnosed ALS, based on Parts A and B fee-for-service claims, between 1 January 2008, 31 December 2014, 104,500 controls...
Burkitt lymphoma (BL) is an aggressive B-cell that occurs worldwide. A study of BL in the US National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program during 1973 to 2005 (n = 3043) revealed three age-specific incidence peaks rates were rising. We studied cases diagnosed SEER 22 2000 2019 11 626) investigate temporal trends. The age-standardized rate was 3.96/million person-years, with a 2.85:1 male-to-female ratio. among both Hispanic White individuals higher...
Obesity is correlated with many biomarkers, but the extent to which these correlate underlying body composition poorly understood. Our objectives were 1) describe/compare distinct contributions of fat/lean mass BMI-metabolite correlations and 2) identify novel metabolite biomarkers mass. The Alberta Physical Activity Breast Cancer Prevention Trial was a 2-center randomized trial healthy, inactive, postmenopausal women (n = 304). BMI (in kg/m2) calculated using weight height, whereas DXA...
Abstract Ovarian cancer is a rare and highly heterogeneous disease usually detected at late stages when outcomes are poor. Population-based screening approaches have not been successful reducing ovarian mortality, but preventive bilateral salpingo-oophorectomy effective preventing in high-risk populations. risk prediction models may allow identification of populations increased for interventions or targeted early detection. We propose life-course approach to based on the time which model...
Background Mood disorders may affect lung cancer risk. We evaluated this hypothesis in two large studies. Methodology/Principal Findings examined 1,939 cases and 2,102 controls from the Environment And Genetics Lung Etiology (EAGLE) case-control study conducted Italy (2002–2005), 82,945 inpatients with a diagnosis 3,586,299 person-years without U.S. Veterans Affairs Inpatient Cohort (VA study), composed of veterans VA hospital admission (1969–1996). In EAGLE, we calculated odds ratios (ORs)...