A5067759844- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Malaria Research and Control
- Cancer Genomics and Diagnostics
- Mosquito-borne diseases and control
- Polyomavirus and related diseases
- Hepatitis C virus research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- Complement system in diseases
- Genetic Associations and Epidemiology
- T-cell and Retrovirus Studies
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- HIV/AIDS drug development and treatment
- Hemoglobinopathies and Related Disorders
- Cervical Cancer and HPV Research
National Cancer Institute
2016-2025
National Institutes of Health
2015-2024
Division of Cancer Epidemiology and Genetics
2015-2024
Government of the United States of America
2018-2020
Cancer Genetics (United States)
2010-2019
The Ohio State University
2016
Cancer Institute (WIA)
2003-2014
Institut Català d'Oncologia
2014
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2014
Biomedical Research Institute
2014
Abstract Although more than 25 million people in sub‐Saharan Africa have human immunodeficiency virus (HIV) infection, little is known regarding their cancer risk. We investigated risk among persons with HIV/AIDS Uganda using record‐linkage. linked records of 12,607 HIV‐infected attending The AIDS Support Organization (TASO) Kyadondo County from October 1988 through December 2002 to the Kampala Cancer Registry. calculated standardized incidence ratios (SIRs) identify increased risks early...
Background People with AIDS have an elevated risk for cancer. We studied the relationship between cancer and AIDS-related immunosuppression as measured by CD4 count at onset. Methods linked records from registries in 11 US regions (1990–1996). 82,217 (86.6%) adults who had a onset survived into follow-up period. calculated standardized incidence ratios (SIRs) AIDS-defining (Kaposi sarcoma [KS], non-Hodgkin lymphoma [NHL] cervical cancer) well non-AIDS-defining cancers 2 years after For each...
Abstract Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge genetics BL thus far has originated from study (pBL), leaving its relationship to adult (aBL) and other lymphomas not fully explored. We sought thoroughly identify somatic changes that underlie lymphomagenesis aBL any molecular features associate with clinical disparities within between pBL aBL. Through comprehensive...
Human herpesvirus 8 (HHV-8) infection is common in Africa. We examined the distribution of HHV-8 within families rural Tanzania to determine routes spread. was assessed by measuring antibody reactivity with a K8.1 (lytic-phase antigen) immunoassay. The prevalence increased from 3.7% (1/27) among infants 58.1% (36/62) children aged 3-4 years and 89.0% (65/73) adults > or =45 years. Women HHV-8-seropositive husbands had 7-fold risk for (odds ratio [OR], 6.9; 95% confidence interval [CI],...
Uganda offers a unique setting in which to study the effect of human immunodeficiency virus-1 (HIV-1) on cancer. HIV-1 is prevalent there, and cancers are known be HIV-associated, such as Kaposi's sarcoma Burkitt's lymphoma, endemic. Adults residing Kampala, Uganda, presenting with cancer city hospitals were interviewed had an HIV test. Of 302 adults recruited, 190 potentially infectious aetiology (cases). The remaining 112 tumours not have formed control group. In addition, 318 children who...
Abstract Background The risk factors and co‐factors for sporadic childhood BL are unknown. We investigated demographic age‐specific characteristics of (0–14 years) in the U.S. Procedure age‐standardized incidence rates (2000 standard population), were calculated using data obtained from 12 registries NCI's Surveillance, Epidemiology, End Results program cases diagnosed 1992 to 2005. Incidence rate ratios 95% confidence intervals (95% CI) by gender, age‐group, race, ethnicity, calendar‐year...
The eruption of Kaposi sarcoma (KS) and aggressive non-Hodgkin lymphoma (NHL) in young homosexual men 1981 the West heralded onset human immunodeficiency virus (HIV) infection epidemic, which remains one biggest challenges to global public health science ever. Because KS NHL were increased >10,000 50-600 times, respectively, with HIV, they designated AIDS defining cancers (ADC). Cervical cancer (CC), 5-10 times was also as an ADC. A few other are elevated including Hodgkin (10 times), anal...
To enhance understanding of etiology, we examined international population-based cancer incidence data for lymphoid leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma and myeloid leukemia among children aged 0-19. Based on temporal trends during 1978-2007 in 24 populations, rates generally have not changed greatly differences diminished some regions. Lymphoid 2003-2007 54 populations varied about 10-fold, with highest US white Hispanics (50.2 per million person-years) Ecuador (48.3) lowest...
The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between early 16th and mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations infer how different African groups contributed North-, South-American, Caribbean populations, in context of geographic geopolitical factors, compared genetic data with demographic history records Trade. observed that West-Central Africa Western Africa-associated ancestry clusters are...
Endemic Burkitt lymphoma (eBL) is a pediatric cancer coendemic with malaria in sub-Saharan Africa, suggesting an etiological link between them. However, previous cross-sectional studies of limited geographic areas have not found convincing association. We used spatially detailed data from the Epidemiology Lymphoma East African Children and Minors (EMBLEM) study to assess this relationship. EMBLEM case–control eBL 2010 through 2016 six regions Kenya, Uganda, Tanzania. To measure intensity...
As part of a larger investigation cancer in Uganda, we conducted case–control study conjunctival squamous cell carcinoma adults presenting at hospitals Kampala. Participants were interviewed about social and lifestyle factors had blood tested for antibodies to HIV, KSHV HPV-16, -18 -45. The odds each factor among 60 people with was compared that 1214 controls other sites or types, using ratios, estimated unconditional logistic regression. Conjunctival associated HIV infection (OR 10.1, 95%...
Objective: To analyse the contribution of maternal survival and HIV status to child (under-5 years) mortality in a rural population cohort South-west Uganda. Methods: Approximately 10 000 people residing 15 neighbouring villages were followed between 1989 2000 using annual censuses serological surveys collect data on births, deaths, adult serostatus. Mother–child records linked, risks (per 1000 births) hazard ratios (HRs) for according serostatus computed, allowing time-varying covariates....