Maureen A. Dyer
A5051887322- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Polymer Surface Interaction Studies
- Renal cell carcinoma treatment
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Biosensors and Analytical Detection
- Cancer-related molecular mechanisms research
- Anodic Oxide Films and Nanostructures
- Circular RNAs in diseases
- Early Childhood Education and Development
- Nanofabrication and Lithography Techniques
- Nanopore and Nanochannel Transport Studies
- MicroRNA in disease regulation
- Genomic variations and chromosomal abnormalities
- Educational Practices and Challenges
- Lung Cancer Research Studies
- Surface Modification and Superhydrophobicity
- Cervical Cancer and HPV Research
- Botulinum Toxin and Related Neurological Disorders
- Immune cells in cancer
- Advanced Biosensing Techniques and Applications
Frederick National Laboratory for Cancer Research
2019-2022
National Cancer Institute
2019-2022
Fusion Academy
2020
Fusion (United States)
2020
Clinical Research Consortium
2020
Leidos (United States)
2017
Pennsylvania State University
2005-2007
Hanson & Associates (United Kingdom)
2007
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 tissues. Proteomic, phosphoproteomic, glycoproteomic analyses were used to characterize proteins their modifications. In addition, whole-genome sequencing, whole-exome methylation, RNA sequencing...
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs HNSCC-associated proteins phosphosites, prioritizes copy number drivers, highlights an oncogenic role for RNA processing genes. investigation mutual exclusivity between FAT1 truncating mutations 11q13.3 amplifications reveals dysregulated actin dynamics as common functional consequence. Phosphoproteomics characterizes two...
Abstract Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge genetics BL thus far has originated from study (pBL), leaving its relationship to adult (aBL) and other lymphomas not fully explored. We sought thoroughly identify somatic changes that underlie lymphomagenesis aBL any molecular features associate with clinical disparities within between pBL aBL. Through comprehensive...
Hyperbranching poly(allylamine) (PAAm) and poly(ethylene glycol) (PEG) on silicon its effect protein adhesion was investigated. involves sequential grafting of polymers a surface with one the components having multiple reactive sites. In this research, PAAm provided amines for PEG diacrylate. Current methodologies generating surfaces include PEG−silane monolayers or polymerized networks. combines nanoscale thickness coverage afforded by polymerization. A multistep approach used to generate...
The research described here investigates the hypothesis that nanoarchitecture contained in a nanowire array is capable of attenuating adverse host response generated when medical devices are implanted body. This response, or biofouling, generates an avascular fibrous mass transfer barrier between device and analyte interest, disabling implant if it sensor. Numerous studies have indicated surface chemistry architecture modulate response. These findings led us to hypothesize nanostructured...
Abstract Burkitt lymphoma (BL) accounts for the majority of pediatric non-Hodgkin lymphomas (NHL) and is relatively rare but significantly more lethal when diagnosed in adults. The global incidence highest Sub-Saharan Africa, where Epstein-Barr virus (EBV) positivity observed 95% all tumors. Both (pBL) adult (aBL) cases are known to share some driver mutations, example MYC translocations, which seen > 90% cases. Sequencing efforts have identified many common somatic alterations that...
Hanson Technologies has developed the automated OmniFresh 1000 system to sample large volumes of produce wash water, collect pathogens, and detect their presence. By collecting a continuous sidestream uses that represent entire lot being washed. The does not require bacterial culture or enrichment, it detects both live dead bacteria in collected using an in-line sensor. Detection occurs array biosensor capable handling samples with complex matrices. Additionally, can be sent for traditional...
Introduction: Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin that disproportionately affects populations in malaria-endemic regions. Although BL curable, age associated with inferior clinical outcomes most series, but the genetic basis of response unknown. Recent large efforts characterization pediatric (pBL) showed key genomic aberrations underlying disease progression. However, these studies have not focused on structural abnormalities a number adult (aBL). In this study, we...