Lina Zgaga
A5062775146- Vitamin D Research Studies
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Pneumonia and Respiratory Infections
- Vitamin C and Antioxidants Research
- Bone health and osteoporosis research
- Glycosylation and Glycoproteins Research
- Folate and B Vitamins Research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Diabetes Treatment and Management
- Nutritional Studies and Diet
- Respiratory viral infections research
- Galectins and Cancer Biology
- Child and Adolescent Health
- Health disparities and outcomes
- Vasculitis and related conditions
- Substance Abuse Treatment and Outcomes
- Birth, Development, and Health
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Gout, Hyperuricemia, Uric Acid
Trinity College Dublin
2016-2025
Institute of Genetics and Cancer
2011-2019
Western General Hospital
2011-2019
Medical Research Council
2014-2019
Royal College of Surgeons in Ireland
2019
Andrija Stampar Teaching Institute of Public Health
2008-2017
University of Zagreb
2008-2017
Tallaght University Hospital
2016-2017
Institute of Public Health
2017
University of Edinburgh
2010-2016
Vitamin D is a steroid hormone precursor that associated with range of human traits and diseases. Previous GWAS serum 25-hydroxyvitamin concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium discovery sample size from 16,125 to 79,366 (all European descent). This larger yields two additional harboring variants (P = 4.7×10
Rationale Lung function measures are heritable traits that predict population morbidity and mortality essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication provided conflicting results. Recently, we undertook a meta-analysis Genome Wide Association Study (GWAS) results lung 20,288 individuals from general (the SpiroMeta consortium). Objectives To comprehensively analyse...
Abstract Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has strong heritable basis. We report genome-wide association analysis 34,627 CRC cases 71,379 controls European ancestry that identifies SNPs at 31 new risk loci. also identify eight independent the previously reported loci, further nine loci only identified in Asian populations. use situ promoter capture Hi-C (CHi-C), gene expression, silico annotation methods to likely target genes SNPs. Whilst...
Over half of all proteins are glycosylated, and alterations in glycosylation have been observed numerous physiological pathological processes. Attached glycans significantly affect protein function; but, contrary to polypeptides, they not directly encoded by genes, the complex processes that regulate their assembly poorly understood. A novel approach combining genome-wide association high-throughput glycomics analysis 2,705 individuals three population cohorts showed common variants...
Central corneal thickness (CCT) is a highly heritable trait, which has been proposed to influence disorders of the anterior segment eye. A genome-wide association study (GWAS) CCT was performed in 2269 individuals from three Croatian and one Scottish population. In discovery set (1445 individuals), two significant associations were identified for single nucleotide polymorphisms rs12447690 (β = 0.23 SD, P 4.4 × 10−9) rs1536482 0.22 7.1 10−8) closest candidate genes (although ≥90 kb away) zinc...