Alison Johnson
A5087467001- Bladder and Urothelial Cancer Treatments
- Carbon dioxide utilization in catalysis
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Catalytic Processes in Materials Science
- Nutritional Studies and Diet
- Sulfur Compounds in Biology
- Air Quality and Health Impacts
- Glutathione Transferases and Polymorphisms
- Fibroblast Growth Factor Research
- Occupational and environmental lung diseases
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Health Policy Implementation Science
- Urinary and Genital Oncology Studies
- Genetic Associations and Epidemiology
- Primary Care and Health Outcomes
- Occupational exposure and asthma
- Health, Environment, Cognitive Aging
- Air Quality Monitoring and Forecasting
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
Vermont Department of Health
2015-2025
Vermont Cancer Support Network
2009-2024
Monash Health
2020-2024
Monash University
2019-2024
Cancer Registry of Norway
2021
National Cancer Institute
2009-2016
Dartmouth College
2009-2016
National Institutes of Health
2009-2016
University of Vermont Medical Center
2010-2016
Cancer Genetics (United States)
2015
Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer past two decades are scarce. This study aimed provide internationally local promote research causes implementation control.
Survival from metastatic cutaneous melanoma is substantially lower than for localized disease. Treatments have been limited, but remarkable clinical improvements reported in trials the last decade. We described characteristics of US patients diagnosed with during 2001-2013 and assessed trends short-term survival distant-stage disease.Trends 1-year net were estimated using Pohar Perme estimator, controlling background mortality life tables all-cause rates by county residence, single year age,...
Cigarette smoking accounts for about 65% of bladder cancer risk in men and 20% -30% women ( 1 ).Studies have consistently shown a two-to threefold among regular cigarette smokers, defined as those who smoked at least one per day 6 months, compared with never ).Experimental evidence has suggested that 2-naphthylamine 4-aminobiphenyl may be the carcinogens smoke -8 ).Numerous studies demonstrated increases increasing duration intensity (cigarettes day) smoking, although levels off higher but...
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 cases 5751 controls, followed by meta-analysis two independently published GWAS, resulting in combined analysis 6911 814 controls European descent. TaqMan genotyping 13 promising single nucleotide polymorphisms P < 1 × 10−5 was pursued follow-up set 801 1307 controls. Two...
Background: Bladder cancer mortality rates have been elevated in northern New England for at least five decades. Incidence Maine, Hampshire, and Vermont are about 20% higher than the United States overall. We explored reasons this excess, focusing on arsenic drinking water from private wells, which particularly prevalent region.
Abstract Bladder cancer results from the combined effects of environmental and genetic factors, smoking being strongest risk factor. Evaluating absolute risks resulting joint factors is critical to assess public health relevance information. Analyses included up 3,942 cases 5,680 controls European background in seven studies. We tested for multiplicative additive interactions between 12 susceptibility loci, individually as a polygenic score (PRS). Thirty-year differences by levels PRS were...
Abstract Despite forming the cornerstone of modern clinical practice for decades, implementation evidence-based medicine at scale remains a crucial challenge health systems. As result, there has been growing need conceptual models to better contextualise and pragmatize use medicine, particularly in tandem with patient-centred care. In this commentary, we highlight emergence learning system as one such model analyse its potential role pragmatizing both We apply lens key activity guideline...
Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen ( PSCA ) gene, as risk factor for bladder cancer. To fine-map this region, we imputed 642 SNPs 100 Kb of rs2294008 in addition to 33 markers genotyped one reported genome-wide study 8,652 subjects. A multivariable logistic regression model adjusted revealed unique signal, rs2978974 r 2 = 0.02, D′ 0.19 with rs2294008). In combined analysis 5,393 cases and 7,324 controls, detected...
Ingestion of disinfection byproducts has been associated with bladder cancer in multiple studies. Although associations other routes exposure have suggested, epidemiologic evidence is limited.
In the past years, European Union (EU) has added edible insects to list of novel foods, allowing an increasing number insect-based products into market. With gaining more popularity in Western world, it is crucial investigate their chemical food safety. This study aimed at investigating possible isotopic patterns different insect species (n = 52) from Asia, Africa and Europe using stable isotope ratio analysis (SIRA) provide a framework for future investigations on authenticity traceability....
A recent genome-wide association study of bladder cancer identified the UGT1A gene cluster on chromosome 2q37.1 as a novel susceptibility locus. The encodes family UDP-glucuronosyltransferases (UGTs), which facilitate cellular detoxification and removal aromatic amines. Bioactivated forms amines found in tobacco smoke industrial chemicals are main risk factors for cancer. within locus was detected by single nucleotide polymorphism (SNP) rs11892031. Now, we performed detailed resequencing,...
Objectives We used data from a large, population-based case–control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry bladder cancer risk. Methods Lifetime occupational histories were obtained by personal interview 1158 patients newly diagnosed with urothelial carcinoma of the 2001–2004, 1402 population controls. Unconditional logistic regression was calculate ORs 95% CIs, adjusted for demographic factors, smoking employment other high-risk...
Aromatic amine components in hair dyes and polymorphisms genes that encode enzymes responsible for dye metabolism may be related to bladder cancer risk. We evaluated the association between use risk effect modification by N-acetyltransferase-1 (NAT1), NAT2, glutathione S-transferase Mu-1 (GSTM1) theta-1 (GSTT1) genotypes a population-based case-control study of 1193 incident cases 1418 controls from Maine, Vermont New Hampshire enrolled 2001 2004. Individuals were interviewed person using...
Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed genome-wide interaction study (GWAS) of smoking bladder based on primary scan data from 3002 cases 4411 controls the National Cancer Institute GWAS. Alternative methods were used to evaluate both additive multiplicative interactions between individual single nucleotide polymorphisms (SNPs) exposure. SNPs P values < 5 × 10−5 evaluated further in an independent dataset 2422 5751 controls....
<h3>Objectives</h3> Metalworking has been associated with an excess risk of bladder cancer in over 20 studies. fluids (MWFs) are suspected as the responsible exposure, but epidemiological data limited. We investigated this association among men New England Bladder Cancer Study using state-of-the-art, quantitative exposure assessment methods. <h3>Methods</h3> Cases (n=895) and population controls (n=1031) provided occupational histories during personal interviews. For selected jobs,...
<h3>Background</h3> Mapping job titles to standardised occupation classification (SOC) codes is an important step in identifying occupational risk factors epidemiological studies. Because manual coding time-consuming and has moderate reliability, we developed algorithm called SOCcer (Standardized Occupation Coding for Computer-assisted Epidemiologic Research) assign SOC-2010 based on free-text description components. <h3>Methods</h3> Job title task-based classifiers were by comparing...
Background: N -nitroso compounds are hypothesized human bladder carcinogens. We investigated ingestion of compound precursors nitrate and nitrite from drinking water diet cancer in the New England Bladder Cancer Study. Methods: Using historical measurements for public supplies measured modeled values private wells, as well self-reported intake, we estimated average concentrations (mg/L NO 3 -N) daily intake (mg/d) 1970 to diagnosis/reference date (987 cases 1,180 controls). overall...