Luis Eduardo Bravo
A5010267392- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Galectins and Cancer Biology
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Veterinary medicine and infectious diseases
- Global Public Health Policies and Epidemiology
- Cervical Cancer and HPV Research
- Microbial Metabolites in Food Biotechnology
- Genetic factors in colorectal cancer
- Medical Coding and Health Information
- Economic and Financial Impacts of Cancer
- Ovarian cancer diagnosis and treatment
- Genital Health and Disease
- Renal Diseases and Glomerulopathies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
- Child and Adolescent Health
- Hepatitis B Virus Studies
Universidad del Valle
2016-2025
The University of Texas MD Anderson Cancer Center
2024
Colombian Geological Survey
2023
Complexo Hospitalario Universitario A Coruña
2020-2023
London School of Hygiene & Tropical Medicine
2016-2022
Hospital Universitario del Valle ESE
2003-2022
London Cancer
2021-2022
Centre international de recherche sur le cancer
2021
Universidade da Coruña
2019
University of California, San Diego
2018
Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer past two decades are scarce. This study aimed provide internationally local promote research causes implementation control.
Significance Theory predicts that chronic pathogens with vertical or familial transmission should become less virulent over time because of coevolution. Although transmitted in this way, Helicobacter pylori is the major causative agent gastric cancer. In two distinct Colombian populations similar levels H. infection but different incidences cancer, we examined human and pathogen ancestry matched samples to assess whether their genomic variation affects severity premalignant lesions....
Global inequalities in access to health care are reflected differences cancer survival. The CONCORD programme was designed assess worldwide and trends population-based In this study, we aimed estimate survival globally for several subtypes of childhood leukaemia. Cancer registries participating were asked submit tumour registrations all children aged 0-14 years who diagnosed with leukaemia between Jan 1, 1995, Dec 31, 2009, followed up until 2009. Haematological malignancies defined by...
Gastric adenocarcinoma is strongly associated with Helicobacter pylori infection; however, most infected persons never develop this malignancy. H. strains harboring the cag pathogenicity island (cag+), which encodes CagA and a type IV secretion system (T4SS), induce more severe disease outcomes. infection also iron deficiency, similarly augments gastric cancer risk. To define influence of deficiency on microbial virulence in carcinogenesis, Mongolian gerbils were maintained iron-depleted...
Objective To evaluate the long-term effect of cumulative time exposed to Helicobacter pylori infection on progression gastric lesions. Design 795 adults with precancerous lesions were randomised receive anti- H. treatment at baseline. Gastric biopsies obtained baseline and 3, 6, 12 16 years. A total 456 individuals attended 16-year visit. Cumulative exposure was calculated as number years infected during follow-up. Multivariable logistic regression models used estimate risk a more advanced...
<h3>Background and aims</h3> <i>Helicobacter pylori</i> colonises the stomach in half of all humans, is principal cause gastric cancer, second leading cancer death worldwide. While rates correlate with <i>H prevalence some areas, there are regions where infection nearly universal, but low. In case Colombia, a 25-fold increase rate Andean mountain (high risk) region compared to coastal (low region, despite similarly high (∼90%) two locations. Our aim was investigate ancestral origin strains...
Abstract Inhabitants of Túquerres in the Colombian Andes have a 25-fold higher risk gastric cancer than inhabitants coastal town Tumaco, despite similar H. pylori prevalences. The microbiota was recently shown animal models to accelerate development -induced precancerous lesions. 20 individuals from each town, matched for age and sex, were selected analyses performed by deep sequencing amplified 16S rDNA. In parallel, status, carriage cag pathogenicity island assignment phylogeographic...
• Stomach cancer incidence and mortality rates varied by 6 5–6-fold, respectively. The highest was seen in Chile, Costa Rica, Colombia, Ecuador, Brazil Peru. Chile (males) Guatemala (females) had some of the world. Incidence declined 4% annually Brazil, Rica from 1997 to 2008. Mortality Non-cardia cancers were 2–13-times more frequent than cardia cancers. Central South America (CSA) are among We describe current burden stomach CSA. obtained regional national-level data 48 population-based...
BackgroundLeukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults 15–99 diagnosed with malignancy during 2000–14 in 61 countries. Here, aimed to examine worldwide trends survival from leukaemia, by age morphology, young patients 0–24 years).MethodsWe 258 population-based cancer registries countries participating CONCORD-3 that submitted on leukaemia. We grouped as (0–14 years), adolescents (15–19 (20–24...
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
<h3>Importance</h3>The long-term effectiveness of Helicobacter pylori eradication programs for preventing gastric cancer will depend on recurrence risk and individual community factors.<h3>Objective</h3>To estimate H assess factors associated with successful 1 year after treatment.<h3>Design, Setting, Participants</h3>Cohort analysis 1463 randomized trial participants aged 21 to 65 years from 7 Latin American communities, who were treated observed between September 2009 July...
Helicobacter pylori incites a futile inflammatory response, which is the key feature of its immunopathogenesis. This leads to ability this bacterial pathogen survive in stomach and cause peptic ulcers gastric cancer. Myeloid cells recruited mucosa during H. infection have been directly implicated modulation host defense against bacterium inflammation. Heme oxygenase-1 (HO-1) an inducible enzyme that exhibits anti-inflammatory functions. Our aim was analyze induction role HO-1 macrophages...