A5035016255- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Global Public Health Policies and Epidemiology
- Genital Health and Disease
- Reproductive tract infections research
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Vaccine Coverage and Hesitancy
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pregnancy and Medication Impact
- DNA Repair Mechanisms
- BRCA gene mutations in cancer
- Reproductive System and Pregnancy
- Head and Neck Cancer Studies
- Carcinogens and Genotoxicity Assessment
- Cleft Lip and Palate Research
- Microbial infections and disease research
- Cancer Risks and Factors
National Cancer Institute
2020-2025
Division of Cancer Epidemiology and Genetics
2020-2025
National Institutes of Health
2020-2023
Hospital de León
2017-2019
The Task Force for Global Health
2018
Centers for Disease Control and Prevention
2018
Centre international de recherche sur le cancer
2016
Canadian Standards Association
2015
University of Alberta
2013
Hospital Universitario de Maracaibo
2010
<h3>Objective</h3> The global burden of colorectal cancer (CRC) is expected to increase by 60% more than 2.2 million new cases and 1.1 deaths 2030. In this study, we aim describe the recent CRC incidence mortality patterns trends linking findings prospects reducing through prevention care. <h3>Design</h3> Estimates sex-specific rates in 2012 were extracted from GLOBOCAN database. Temporal assessed for 37 countries using data <i>Cancer Incidence Five Continents</i> (CI5) volumes I–X WHO...
Abstract Background The authors investigated the durability of vaccine efficacy (VE) against human papillomavirus (HPV)16 or 18 infections and antibody response among nonrandomly assigned women who received a single dose bivalent HPV compared with multiple doses unvaccinated women. Methods were between HPV16 18-vaccinated aged to 25 years one (N = 112), two 62), three 1365) doses, age- geography-matched 1783) in long-term follow-up Costa Rica Vaccine Trial. Cervical measured at study visits,...
Cancer burden is increasing in Central and South America (CSA). We describe the current of cancer CSA. obtained regional national-level incidence data from 48 population-based registries (13 countries) nation-wide mortality WHO (18 countries). estimated world population age-standardized rates per 100,000 person-years. The leading cancers diagnosed were prostate, lung, breast, cervix, colorectal, stomach, which also primary causes mortality. Countries high/very high human development index...
• Stomach cancer incidence and mortality rates varied by 6 5–6-fold, respectively. The highest was seen in Chile, Costa Rica, Colombia, Ecuador, Brazil Peru. Chile (males) Guatemala (females) had some of the world. Incidence declined 4% annually Brazil, Rica from 1997 to 2008. Mortality Non-cardia cancers were 2–13-times more frequent than cardia cancers. Central South America (CSA) are among We describe current burden stomach CSA. obtained regional national-level data 48 population-based...
Central and South America comprise one of the areas characterized by high incidence rates for head neck cancer. We describe geographical temporal trends in mortality cancers American region order to identify opportunities intervention on major identified risk factors: tobacco control, alcohol use viral infections. obtained regional- national-level data from 48 population-based cancer registries 13 countries deaths WHO database 18 countries. Age-standardized (ASR) (ASMR) per 100,000...
More than 20 years after cytology-based screening was introduced in Central and South America (CSA), cervical cancer remains a leading cause of incidence mortality the region. Although several population-based registries exist region, few comprehensive analyses have been conducted to describe status control. Population-based data from 13 countries 18 CSA were analyzed. Standardized rates estimated time trend analysis performed when information available. In addition, search available on HPV...
The colorectal cancer (CRC) burden is increasing in Central and South American due to an ongoing transition towards higher levels of human development. We describe the CRC region review current status disease control. obtained regional- national-level incidence data from 48 population-based registries 13 countries, as well deaths WHO mortality database for 18 countries. estimated world population age-standardized (ASR) (ASMR) rates per 100,000 person-years 2003–2007 annual percentage change...
Although malignant tumors of the brain and central nervous system (CNS) represent less than 3% new cancer cases estimated worldwide, they cause significant morbidity in case gliomas, most common histological type, have a poor prognosis. We describe patterns trends CNS incidence mortality Central South America. obtained regional- national-level data from 48 population-based registries 13 countries deaths WHO database for 18 countries. world population age-standardized rates (ASRs) (ASMRs) per...
The burden of breast cancer has increased worldwide. Breast mortality been increasing in Central and South America (CSA) the last few decades. We describe current CSA review status disease control. obtained regional- national-level incidence data from 48 population-based registries 13 countries deaths WHO database for 18 countries. estimated world population age-standardized rates per 100,000 person-years 2003–2007 annual percentage change to time trends. In most recent 5-year period,...
The incidence of prostate cancer has increased in Central and South America (CSA) the last few decades. We describe geographical patterns trends CSA. obtained regional national-level data from 48 population-based registries 13 countries nation-wide deaths WHO mortality database for 18 countries. estimated world population age-standardized (ASR) (ASMR) rates per 100,000 person-years 2003–2007 annual percent change (EAPC) to time trends. Prostate was most common diagnosis one leading causes...
Helicobacter pylori infection affects about half of the world's population and is usually acquired in childhood. The has been associated with chronic gastritis, peptic ulcer, stomach cancer adulthood. Little known, however, its consequences on child health. We examined effect H. growth among school-age children Colombian Andes by comparing velocity presence absence infection.Children who were 4-8 years old 2004 followed up a community where infected received anti-H. treatment (n = 165)...
Very little is known about the burden of cutaneous melanoma in Central and South America, despite existence a reasonable amount population-based data. We present data on incidence calculated standardized way for as well an overview primary secondary prevention issues region.
Incidence of thyroid cancer (TC) is rapidly increasing worldwide, but little known about the TC burden in Central and South America (CSA). We describe geographic patterns trends by sex CSA. obtained regional- national-level incidence data from 48 population-based registries 13 countries nationwide deaths WHO mortality database for 18 countries. estimated world population age-standardized rates (ASRs) (ASMRs) per 100,000 person-years. calculated ASRs histological subtype. annual percentage...
HPV vaccination of adolescent girls is the most effective measure to prevent cervical cancer. The World Health Organization recommends that receive two doses vaccine but only a small proportion from regions with highest disease burden are vaccinated because cost and logistical considerations. Our Costa Rica Vaccine trial suggested one dose bivalent provides robust lasting protection against persistent infections for over decade. Data post-licensure quadrivalent in India also single may be...
The burden of non-Hodgkin lymphoma (NHL) has increased in some Central and South American countries. We describe the current patterns trends NHL incidence mortality America. obtained regional- national-level data from 48 population-based cancer registries 13 countries, WHO database for 18 estimated world population age-standardized rates (ASRs) (ASMRs) per 100,000 person-years 2003–2007, presented distributions by histological subtype. varied between countries 2–8- 6-fold, respectively. ASRs...
Central and South American countries (including Cuba) are experiencing rapid socio-demographic epidemiologic changes the nature of health problems undergoing transition from infectious to chronic diseases, including cancer. Countries poorly prepared respond effectively subsequent challenges posed by new patterns disease. Existing data delineating number cancer cases distribution types each country in region sparse due limitations on information systems for recording incidence mortality...
Whether existing serological assays are sufficiently robust to measure the lower antibody levels expected following single-dose HPV vaccination is unknown.
New approaches to control HPV infections and prevent progression cervical precancer are needed. We investigate the probability of viral clearance in women infected with HPV16/18 without evidence at study enrollment inform research efforts targeted reducing cancer. included 530 aged 18-25 who tested DNA-positive did not have cytological high-grade-squamous-intraepithelial-lesion (HSIL) CVT. At each visit, clinicians collected cells for cytology HPV-DNA testing. Those abnormal were referred...
Abstract Background: Evaluating impact/effectiveness of human papillomavirus (HPV) vaccination generally assumes stability in factors driving transmission, which might not be valid. We aimed to develop, validate, and test a grouping non-vaccine-preventable HPV (NVP-HPV) types as molecular indicator associated with sexual behaviours control for changes transmission risk. Methods: used data from the National Surveys Sexual Attitudes Lifestyles (Natsal-2, 1999-2001, N=1,849; Natsal-3,...
We conducted a case-control study to determine risk factors for developing encephalitis among West Nile virus cases when compared with age-, gender and race/ethnicity-matched hospitalized controls. In the multivariable conditional logistic regression analysis, we identified following independent associated being an case: hypertension (OR 4.0; P = 0.005), immunosuppressing conditions 5.6; 0.001) cardiovascular disease 28.3; < 0.001). Individuals these comorbidities should be targeted...
Abstract Human Papillomavirus (HPV) type variants have been classified into lineages and sublineages based upon their whole genome sequence. Here we examined the specificity of antibodies generated following natural infection with lineage oncogenic types (HPV16, 18, 31, 33, 45, 52 58) by testing serum samples assembled from existing archives women residing in Africa, The Americas, Asia or Europe against representative lineage-specific pseudoviruses for each genotype. We subjected resulting...
Lung cancer is the most commonly diagnosed and leading cause of death in world. In Central South America lung now one frequent cancers cancer-related both sexes. We describe patterns trends incidence mortality give a brief overview current status tobacco control measures based on recent MPOWER report. obtained regional national-level data from 48 population-based registries 13 countries deaths WHO database for 18 countries. estimated world population age-standardized rates per 100,000...
Oesophageal cancer shows marked geographic variations and is one of the leading causes death worldwide. We described burden this malignancy in Central South America. Regional national level incidence data were obtained from 48 population-based registries 13 countries. Mortality WHO mortality database. Incidence oesophageal by histological subtype available high-quality registries. Males had higher rates than females (male-to-female ratios: 2–6:1 2–5:1). In 2003–2007, highest Brazil, Uruguay,...