A5080548951- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Hepatitis C virus research
- Cancer Research and Treatments
- Mechanisms of cancer metastasis
- Immune Response and Inflammation
- Connective Tissue Growth Factor Research
- Bone and Dental Protein Studies
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Folate and B Vitamins Research
National Cancer Institute
2010-2024
Uniformed Services University of the Health Sciences
2015-2024
National Institutes of Health
2010-2023
Henry M. Jackson Foundation
2019-2023
Walter Reed National Military Medical Center
2015-2023
Indian Council of Medical Research
2007-2015
Division of Cancer Epidemiology and Genetics
2010-2013
Center for Cancer Research
2012
Vermont Cancer Support Network
2012
University of Vermont
2012
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3′ untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 HLA-DPB1, respectively, as independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are mRNA expression HLA-DPB1. gene expression-associated (eSNPs) normal liver samples obtained from 651 individuals European ancestry by integrating genotype (∼650 000...
Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen ( PSCA ) gene, as risk factor for bladder cancer. To fine-map this region, we imputed 642 SNPs 100 Kb of rs2294008 in addition to 33 markers genotyped one reported genome-wide study 8,652 subjects. A multivariable logistic regression model adjusted revealed unique signal, rs2978974 r 2 = 0.02, D′ 0.19 with rs2294008). In combined analysis 5,393 cases and 7,324 controls, detected...
In this study, we investigated the effects of natural antioxidant curcumin on HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that is not only a potent inhibitor for activity host nuclear transcription factors AP-1 NF-kB but it also selectively suppresses HPV16/E6 oncogene during carcinogenic process in cancer cells. This study suggests therapeutic potential high-risk human papilloma virus (HPV)-infected cancers.
Evaluation of cancer genomes in global context is great interest light changing ethnic distribution the world population. We focused our study on men African ancestry because their disproportionately higher rate prostate (CaP) incidence and mortality. present a systematic whole genome analyses, revealing alterations that differentiate American (AA) Caucasian (CA) CaP genomes. discovered recurrent deletion chromosome 3q13.31 centering LSAMP locus was prevalent tumors from AA (cumulative...
Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency BRCA1 (BRCA1/2) gene alterations was recently reported metastatic castration-resistant PCa specimens. Mutations vary racial ethnic groups including African-American (AA) Caucasian-American (CA) populations. genes were sequenced (Ion AmpliSeq targeted sequencing) archived blood DNA specimens 1240 patients, 30% AA three different cohorts: localized early stage (T2) (N = 935); advanced...
Investigation of the potential association single nucleotide polymorphisms (SNPs) at -308 G/A and -238 Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women.The study included 165 histologically confirmed cases 45 precancer 120 patients an equal number (165) healthy controls normal cytology. PCR-RFLP was employed analyze TNFalpha promoter polymorphisms, which were by direct sequencing. Both screened for Human Papillomavirus (HPV)...
Abstract Background A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as novel genetic risk factor for breast cancer, and this was stronger patients with estrogen receptor (ER) + versus ER - cancer. Results We found between SNP expression of NOTCH2 gene located region. Examined 180 tumors, to be lowest tumors TP53 mutations highest wild-type/ER (p = 0.0059). In latter group, particularly increased carriers...
Open AccessJournal of UrologyAdult Urology1 Feb 2021A Urine Exosome Gene Expression Panel Distinguishes between Indolent and Aggressive Prostate Cancers at Biopsy Indu Kohaar, Yongmei Chen, Sreedatta Banerjee, Talaibek Borbiev, Huai-Ching Kuo, Amina Ali, Lakshmi Ravindranath, Jacob Kagan, Sudhir Srivastava, Albert Dobi, Isabell A. Sesterhenn, Inger L. Rosner, Jennifer Cullen, Shiv Gyorgy Petrovics KohaarIndu Kohaar *Correspondence: E-mail Address: [email protected] Center for Disease...
Persistent hepatitis C virus (HCV) infection is a primary etiological factor for the development of chronic liver disease, including cirrhosis and cancer. A recent study identified occludin (OCLN), an integral tight junction protein, as one key factors HCV entry into cells. We explored splicing diversity OCLN in normal human observed variable expression alternative splice variants, two known forms (WT-OCLN OCLN-ex4del) six novel (OCLN-ex7ext, OCLN-ex3pdel, OCLN-ex3del, OCLN-ex3-4del,...
Abstract In prostate cancer, emerging data highlight the role of DNA damage repair genes (DDRGs) in aggressive forms disease. However, DDRG mutations African American men are not yet fully defined. Here, we profile germline all known DDRGs ( N = 276) using whole genome sequences from blood a matched cohort patients with primary cancer comprising 300 and European Ancestry patients, to determine whether mutation status can enhance patient stratification for specific targeted therapies. show...
Abstract A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as novel susceptibility variant. This is located upstream CCNE1 gene, which encodes cyclin E, cell-cycle protein. We performed fine-mapping analysis using data from two GWAS (5,942 cases and 10,857 controls). found that original represents group 47 linked SNPs (with r2 ≥ 0.7) associated with increased risk. From this group, we selected functional promoter variant...
This mini review summarizes the currently available clinical biofluid assays for PCa. The second most prevalent cancer worldwide is PCa a heterogeneous disease, with large percentage of prostate tumors being indolent, and relatively slow metastatic potential. However, due to high case numbers, absolute number PCa-related deaths still high. In fact, it causes highest in American men. As first step diagnosis PCa, PSA test has been widely used. low specificity, which results false positives...
As current evidence suggests the involvement of epigenetic modification tumour suppressor genes in human cancer, we investigated aberrant promoter methylation FHIT and RASSF1A papillomavirus (HPV)-mediated cervical cancer Indian women. We analysed 60 tissue biopsies different clinical stage histological grading 23 healthy control samples with normal cytology. Methylation-specific polymerase chain reaction (MSP) was performed to analyse status confirmed by sequencing. Both patients controls...
A monoclonal antibody against prostate stem cell antigen (PSCA) has emerged as a novel cancer therapy currently being tested in clinical trials for and pancreatic cancers, but this treatment is likely to be efficient only patients with PSCA-expressing tumors. The present study demonstrates that genetic variant (rs2294008) discovered by bladder genome-wide association studies strong predictor of PSCA protein expression tumors, measured two-sided multivariable linear regression (P =...
Human papillomavirus is considered to be a major aetiological factor but not sufficient for the development of cervical cancer. Other host factors, including altered homocysteine levels, functional marker folate inadequacy, might contribute carcinogenic process. Herein we investigated potential association levels and MTHFR polymorphisms with cancer in 203 histologically confirmed cases 39 precancer 231 healthy controls normal cytology. Both patients were screened human infection. We found...
The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) CCND1 with susceptibility to cervical cancer was investigated. study included 200 cases along an equal number healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk development (odds ratio (OR) 2.49; 95% confidence interval (CI)...
// Wusheng Yan 1 , 2 * Muhammad Jamal Shyh-Han Tan Yingjie Song Denise Young Yongmei Chen Shilpa Katta Kai Ying Lakshmi Ravindranath Tarah Woodle Indu Kohaar Jennifer Cullen 3 Jacob Kagan 4 Sudhir Srivastava Albert Dobi David G. McLeod Inger L. Rosner Isabell A. Sesterhenn 5 Alagarsamy Srinivasan Shiv and Gyorgy Petrovics Henry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA Center Prostate Disease Research, Department Surgery, Uniformed Services...
Pathogenesis of fulminant hepatic failure (FHF) in nonacetaminophen etiology is not elucidated. We have investigated the significance tumor necrosis factor (TNF) type-I receptor (TNF-R1) and Fas (CD95, APO-1) FHF.Liver biopsy samples were obtained from 14 FHF patients. Liver tissue 10 patients with acute viral hepatitis (AVH) cases who died, unrelated to liver disease served as controls. Immunohistochemical methods employed analyze expression TNF-R1 hepatocytes.Immunohistochemical analysis...