A5036947619- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Fibroblast Growth Factor Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Skin and Cellular Biology Research
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Soft tissue tumor case studies
- Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Occupational and environmental lung diseases
- Renal and related cancers
Universitat Pompeu Fabra
2012-2025
Hospital del Mar Research Institute
2014-2025
Hospital Del Mar
2010-2023
Memorial Sloan Kettering Cancer Center
2023
Institut de recherche mathématique de Rennes
2023
Universitat Autònoma de Barcelona
2000-2021
Parc de Salut
2012-2021
Municipal Institute for Medical Research
2005-2020
Hospital Universitari de Vic
1993-2019
Universitat de Barcelona
1997-2019
The recently recognized Xp11 translocation renal cell carcinomas (RCCs), all of which bear gene fusions involving the TFE3 transcription factor gene, comprise at least one-third pediatric RCC. Only rare adult cases have been reported, without detailed pathologic analysis. We identified and analyzed 28 RCC in patients over age 20 years. All were confirmed by immunohistochemistry, a sensitive specific marker neoplasms with fusions, can be applied to archival material. Three also genetically....
Purpose To determine the frequency and prognostic value of fibroblast growth factor receptor 3 (FGFR3) mutations in patients with nonmuscle invasive bladder tumors according to tumor stage grade. Patients Methods Seven hundred seventy-two newly diagnosed were recruited. Tumors reviewed by expert pathologists. prospectively followed-up (median, 62.6 months for disease-free patients) through review hospital records telephone interviews. The sequence exons 7 10 FGFR3 was analyzed polymerase...
Injury of the diaphragm may have clinical relevance having been reported in cases sudden infant death syndrome or fatal asthma. However, examination injury after acute inspiratory loading has not reported. The purpose this study was to determine whether an overload induces human and if from chronic obstructive pulmonary disease (COPD) is more susceptible injury. Eighteen patients with COPD 11 control normal function (62 +/- 10 yr) undergoing thoracotomy laparotomy were studied. A threshold...
Abstract We examined the effects of dose, type tobacco, cessation, inhalation, and environmental tobacco smoke exposure on bladder cancer risk among 1,219 patients with newly diagnosed 1,271 controls recruited from 18 hospitals in Spain. used unconditional logistic regression to estimate odds ratios (OR) 95% confidence intervals (95% CI) for association between various characteristics cigarette smoking. Current smokers (men: OR, 7.4; CI, 5.3-10.4; women: 5.1; 1.6-16.4) former 3.8; 2.8-5.3;...
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 cases 5751 controls, followed by meta-analysis two independently published GWAS, resulting in combined analysis 6911 814 controls European descent. TaqMan genotyping 13 promising single nucleotide polymorphisms P < 1 × 10−5 was pursued follow-up set 801 1307 controls. Two...
Abstract Bladder cancer results from the combined effects of environmental and genetic factors, smoking being strongest risk factor. Evaluating absolute risks resulting joint factors is critical to assess public health relevance information. Analyses included up 3,942 cases 5,680 controls European background in seven studies. We tested for multiplicative additive interactions between 12 susceptibility loci, individually as a polygenic score (PRS). Thirty-year differences by levels PRS were...
New, non-ablative methods can be used in skin rejuvenation. Histologic analysis of IPL effects on facial, sun-damaged skin.Five female subjects, wrinkle class I or II and Fitzpatrick types I, II, III. treatment: once monthly, 560-nm cut-off filters, spot size 8x35 mm, 28-36 J/cm. Routine histology electron microscopy 2-mm punches, before treatment then 1 week, 3 months, 12 months.Pre-treatment specimens contained solar elastosis perifollicular lymphoid infiltrates. Collagen elastic fibers...
Abstract FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer. are associated with low-grade tumors a favorable prognosis. alterations advanced and, possibly, poor We focus here on subgroup T1G3 superficial because they major clinical challenge. Patients (n = 119) were identified from prospective study 1,356 cases. Mutations (exons 7, 10, 15) 4-9) analyzed using PCR direct sequencing. All cases followed for...
Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen ( PSCA ) gene, as risk factor for bladder cancer. To fine-map this region, we imputed 642 SNPs 100 Kb of rs2294008 in addition to 33 markers genotyped one reported genome-wide study 8,652 subjects. A multivariable logistic regression model adjusted revealed unique signal, rs2978974 r 2 = 0.02, D′ 0.19 with rs2294008). In combined analysis 5,393 cases and 7,324 controls, detected...
Abstract High-grade T1 (HGT1) bladder cancer is the highest risk subtype of non–muscle-invasive with unpredictable outcome and poorly understood factors. Here, we examined association somatic mutation profiles nonrecurrent disease (GO, good outcome), recurrence (R), or progression (PD) in a cohort HGT1 patients. Exome sequencing was performed on 62 15 matched normal tissue samples. Both tumor only (TO) paired analyses were performed, focusing 95 genes known to be mutated cancer. Somatic...
We attempted to determine the relationship between tumor volume and extent of localized prostate cancer, as well interrelationships with specific antigen (PSA) level, grade stage.Serial whole mount sections from 128 patients who underwent radical prostatectomy were analyzed using a computer assisted volumetric program. Statistical evaluations performed logistic simple regression analyses.The median for organ confined disease was significantly lower than those extraprostatic extension (1.25...
The clinical significance of intestinal spirochetosis is uncertain, therefore the aim present paper was to assess prevalence histological in patients with and without chronic watery diarrhea evaluate its relevance.A prospective diagnostic work-up made on biopsy samples taken from submitted between 1994 2004 (1174 colonoscopies multiple biopsies). Three other positive cases identified routine endoscopic biopsies also were reviewed. In addition, 100 asymptomatic control a random sample another...
Abstract BACKGROUND Although prostate cancer (PC) mortality disproportionately affects African‐American (AA) men, limited data exist comparing the pathologic characteristics of white and AA patients with nonpalpable PC (clinical stage T1c). METHODS The authors reviewed radical prostatectomy (RP) specimens from 37 consecutive men clinical T1c 35 who were matched for age, stage, serum prostate‐specific antigen (PSA) level, year surgery, weight, biopsy strategy. Pathologic compared after...
Objectives: We investigated the association between occupation and bladder cancer in a hospital-based case–control study conducted Spain. Methods: 1219 patients with transitional cell carcinoma of urinary 1271 controls selected from 18 hospitals Spain June 1998 September 2000 provided detailed information on life-time occupational history, smoking habits, medical other factors. used unconditional logistic regression to calculate odds ratios (OR) 95% confidence intervals (CI) for each...