A5038507025- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Radiopharmaceutical Chemistry and Applications
- Breast Cancer Treatment Studies
- Voice and Speech Disorders
- Cancer, Lipids, and Metabolism
- Tracheal and airway disorders
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Computational Drug Discovery Methods
- Cancer-related Molecular Pathways
- Nerve Injury and Rehabilitation
- Ear and Head Tumors
- Reconstructive Surgery and Microvascular Techniques
- Semiconductor Quantum Structures and Devices
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
GEICAM – Spanish Breast Cancer Group
2018-2024
Real Jardín Botánico
2024
Paul Drude Institute for Solid State Electronics
2022-2023
Forschungsverbund Berlin
2022-2023
IMDEA Food
2013-2022
McMaster University
2022
Universidad Autónoma de Madrid
1987-2022
Madrid Institute for Advanced Studies
2014-2022
University of St. Gallen
2022
Weierstrass Institute for Applied Analysis and Stochastics
2022
// Ruth Sánchez-Martínez 1 , Silvia Cruz-Gil 1, * Marta Gómez de Cedrón Mónica Álvarez-Fernández 2 Teodoro Vargas Susana Molina Belén García Jesús Herranz 3 Juan Moreno-Rubio 4, 5 Guillermo Reglero Mirna Pérez-Moreno 6 Jaime Feliu 4 Marcos Malumbres Ana Ramírez Molecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM + CSIC, Madrid, Spain Cell Division Spanish National...
Abstract Purpose: In hormone receptor–positive (HR+)/HER2− metastatic breast cancer (MBC), it is imperative to identify patients who respond poorly cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and discover therapeutic targets reverse this resistance. Non-luminal subtype high levels of CCNE1 are candidate biomarkers in setting, but further validation needed. Experimental Design: We performed mRNA gene expression profiling correlation with progression-free survival (PFS) on 455 tumor...
// Teodoro Vargas 1 , Juan Moreno-Rubio 2, 3 Jesús Herranz 4 Paloma Cejas 5 Susana Molina Margarita González-Vallinas Marta Mendiola 2 Emilio Burgos 5, 6 Cristina Aguayo 7 Ana B. Custodio Isidro Machado 8 David Ramos 9 Meritxell Gironella 10 Isabel Espinosa-Salinas Ricardo 11 Roberto Martín-Hernández Alberto Risueño 12 Javier De Las Rivas Guillermo Reglero Yaya 13 Carlos Fernández-Martos Jorge Aparicio 14 Joan Maurel 15 Jaime Feliu Ramírez de Molecular Oncology, IMDEA-Food Institute, CEI...
An abnormal acyl-CoA synthetase/stearoyl-CoA desaturase (ACSL/SCD) lipid network fuels colon cancer progression, endowing cells with invasive and migratory properties. Therapies against this metabolic may be useful to improve clinical outcomes. Because micro-RNAs (miRNAs/miRs) are important epigenetic regulators, we investigated novel miRNAs targeting pro-tumorigenic axis; hence used as therapeutic or prognostic miRNAs. Thirty-one putative common were predicted simultaneously target the...
Abstract Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood humans before after 36 or 24 hours of fasting, respectively, measure lipid composition erythrocyte membranes, circulating micro RNAs (miRNAs), RNA expression at peripheral mononuclear cells (PBMCs). coordinately affects proportion polyunsaturated versus saturated monounsaturated fatty acids membrane; reduces insulin...
Glycosyltransferase enzyme GCNT3, has been proposed as a biomarker for prognosis in colorectal cancer (CRC). Our study goes depth into the molecular basis of GCNT3 role tumorigenesis and drug resistance, it explores its potential epithelial ovarian (EOC). High levels are associated with increased sensibility to 5-fluoracil metastatic cells. Accordingly, re-expression leads gain anti-carcinogenic cellular properties by reducing cell growth, invasion changing metabolic capacities. Integrated...
Strong evidence suggests that lipid metabolism (LM) has an essential role in tumor growth to support special energetic and structural requirements of cells. Recently, overexpression LM-related genes, apolipoproteins related metabolic syndrome, ACSL/SCD network involved fatty acid activation have been proposed as prognostic markers colon cancer (CC). Furthermore, this latter recently demonstrated confer invasive stem cell properties cells promoting aggressiveness patient relapse. With the aim...
Prognostic and predictive biomarkers to cyclin-dependent kinases 4 6 inhibitors are lacking. Circulating tumor DNA (ctDNA) can be used profile these patients dynamic changes in ctDNA could an early predictor of treatment efficacy. Here, we conducted plasma profiling from the PEARL trial comparing palbociclib+fulvestrant versus capecitabine investigate associations between baseline genomic landscape on-treatment dynamics with efficacy.Correlative blood samples were collected at [cycle 1-day 1...
To study the complications of total laryngectomy, we evaluated 471 previously untreated patients who underwent laryngectomy between 1980 and 1997. This series consisted 358 with primary carcinoma larynx 113 hypopharynx. Concurrent neck dissection was performed in 85% patients. Complications were studied relation to age, T N stage, previous tracheostomy, dissection, margins, reconstruction, tracheoesophageal puncture, surgeon. Complication treatment hospitalization also evaluated. The overall...
The objective of the study was to assess psychosocial adjustment 111 patients, and 87 partners, after laryngeal cancer surgery. Sixty-nine patients were grouped as having had radical surgery (total or near-total laryngectomy), 30 functional (horizontal supraglottic laryngectomy cordectomy). Psychosocial Adjustment Illness Scale Self Report questionnaire used primary outcome. No significant differences found between groups when global domain compared. Patient partner responses almost...
Functional neck dissection (FND) is a neck-functional, tumor-radical approach for the management of in patients with head and cancer. Based on anatomic knowledge lymphatic compartments neck, FND different surgical technique rather than modification classic procedure described by Crile. From an oncologic viewpoint, relatively safe operation to treat cervical spread from cancer as long indications technical details are carefully followed. In this report, based our experience more 1,000 FNDs,...
The use of large-scale compound screening has become a key component drug discovery projects in both the pharmaceutical and biotechnological industries. More recently, these activities have also been embraced by academic community as major tool for chemical genomic activities. High-throughput (HTS) constitute step initial efforts involve large quantities biological reagents, hundreds thousands to millions compounds, utilization expensive equipment. All factors make it very important evaluate...
Abstract Part of the substantial unexplained familial aggregation breast cancer may be due to interactions between common variants, but few studies have had adequate statistical power detect realistic magnitude. We aimed assess all two-way in susceptibility 70 917 single nucleotide polymorphisms (SNPs) selected primarily based on prior evidence a marginal effect. Thirty-eight international contributed data for 46 450 cases and 42 461 controls European origin as part multi-consortium project...
Studies have recently suggested that metabolic syndrome and its components increase the risk of colorectal cancer. Both diseases are increasing in most countries, genetic association between them has not been fully elucidated. The objective this study was to assess factors or related conditions (obesity, hyperlipidaemia, diabetes mellitus type 2) clinical outcome stage II cancer patients. Expression levels several genes associated alterations were analysed by real‐time qPCR two equivalent...
// Lara P. Fernández 1 , Ricardo Ramos-Ruiz 2 Jesús Herranz 3 Roberto Martín-Hernández Teodoro Vargas Marta Mendiola 4, 5, 6 Laura Guerra 7 Guillermo Reglero Jaime Feliu 6, 8, 9 and Ana Ramírez de Molina Molecular Oncology Group, IMDEA Food Institute, CEI UAM + CSIC, Madrid, Spain Genomics Unit, Parque Científico Biostatistics Bioinformatics IMDEA-Food UAM+CSIC, 4 Pathology Section, Institute of Medical Genetics (INGEMM) La Paz University Hospital, 5 Therapeutic Targets Lab, IdiPAZ, CIBERONC...
Abstract Purpose: Predictive biomarkers for capecitabine benefit in triple-negative breast cancer (TNBC) have been recently proposed using samples from phase III clinical trials, including non-basal phenotype and related to angiogenesis, stroma, activation genes. We aimed validate these findings on the larger GEICAM/CIBOMA trial. Experimental Design: Tumor tissues patients with TNBC randomized standard (neo)adjuvant chemotherapy followed by versus observation were analyzed a 164-gene...
Derived neutrophil-to-lymphocyte ratio (dNLR) is a biomarker associated with clinical outcome in breast cancer (BC). We analyzed the association of dNLR pathological complete response (pCR) triple-negative BC (TNBC) patients receiving neoadjuvant chemotherapy (CT).This retrospective analysis two randomized studies involving early stage/locally advanced TNBC anthracycline/taxane-based CT+/-carboplatin (GEICAM/2006-03) or nab-paclitaxel/paclitaxel followed by anthracycline regimen (ETNA). was...