A5062696393- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Genetic factors in colorectal cancer
- Advanced MRI Techniques and Applications
- Nutritional Studies and Diet
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Protein Kinase Regulation and GTPase Signaling
- Metabolism, Diabetes, and Cancer
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Obesity, Physical Activity, Diet
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Banking stability, regulation, efficiency
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
- Mitochondrial Function and Pathology
- Global Financial Crisis and Policies
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
Madrid Institute for Advanced Studies
2016-2025
IMDEA Food
2016-2025
Universidad Autónoma de Madrid
2016-2025
Bank of Spain
2023-2025
Centro Nacional de Biotecnología
2007-2023
Consejo Superior de Investigaciones Científicas
2001-2023
Central University of Venezuela
2021
Hospital Israelita Albert Einstein
2019
Cornell University
2019
Molecular Oncology (United States)
2019
Human urolithin gut microbiota metabotypes are mainly determined by aging.
// Ruth Sánchez-Martínez 1 , Silvia Cruz-Gil 1, * Marta Gómez de Cedrón Mónica Álvarez-Fernández 2 Teodoro Vargas Susana Molina Belén García Jesús Herranz 3 Juan Moreno-Rubio 4, 5 Guillermo Reglero Mirna Pérez-Moreno 6 Jaime Feliu 4 Marcos Malumbres Ana Ramírez Molecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM + CSIC, Madrid, Spain Cell Division Spanish National...
Scope The gut microbiota ellagitannin‐metabolizing phenotypes (i.e., urolithin metabotypes [UMs]) are proposed as potential cardiovascular disease (CVD) risk biomarkers because the host blood lipid profile is reported to be associated with specific UMs. However, link for this association remains unknown so far. Methods and Results microbiome of 249 healthy individuals analyzed using 16S rDNA sequencing analysis. Individuals also stratified by UMs (UM‐A, UM‐B, UM‐0) enterotypes ( Bacteroides...
At the time of diagnosis, 20% patients with colorectal cancer present metastasis. Among individuals primary lesions, 50% them will develop distant tumours time. Therefore, early diagnosis and prediction aggressiveness is crucial for therapy design disease prognosis. Tumoral cells must undergo significant changes in energy metabolism to meet increased structural energetic demands cell proliferation, metabolic alterations are considered be a hallmark cancer. Here, we ATP-binding cassette...
Abstract MN58b is a novel anticancer drug that inhibits choline kinase, resulting in inhibition of phosphocholine synthesis. The aim this work was to develop noninvasive and robust pharmacodynamic biomarker for target and, potentially, tumor response following treatment. Human HT29 (colon) MDA-MB-231 (breast) carcinoma cells were examined by proton (1H) phosphorus (31P) magnetic resonance spectroscopy (MRS) before after treatment with both culture xenografts. An vitro time course study also...
Breast cancer is still one of the most important tumors among women in industrialized countries. Improvement both understanding molecular events associated with disease and development new additional treatments an goal to be achieved. Choline kinase (ChoK) increased human mammary high incidence, this activation clinical variable indicators greater malignancy. Here, we have investigated role ChoK breast found that necessary sufficient for growth factor-induced proliferation primary epithelial...
Background The Kennedy pathway generates phosphocoline and phosphoethanolamine through its two branches. Choline Kinase (ChoK) is the first enzyme of branch synthesis phosphocholine, major component plasma membrane. ChoK family proteins composed by ChoKα ChoKβ isoforms, one with different variants splicing. Recently has been implicated in carcinogenic process, since it over-expressed a variety human cancers. However, no evidence for role carcinogenesis reported. Methodology/Principal...
Colorectal and pancreatic cancers remain important contributors to cancer mortality burden and, therefore, new therapeutic approaches are urgently needed. Rosemary (Rosmarinus officinalis L.) extracts its components have been reported as natural potent antiproliferative agents against cells. However, potentially apply rosemary a complementary approach for therapy, additional information regarding the most effective composition, antitumor effect in vivo main molecular mediators is still In...
// Teodoro Vargas 1 , Juan Moreno-Rubio 2, 3 Jesús Herranz 4 Paloma Cejas 5 Susana Molina Margarita González-Vallinas Marta Mendiola 2 Emilio Burgos 5, 6 Cristina Aguayo 7 Ana B. Custodio Isidro Machado 8 David Ramos 9 Meritxell Gironella 10 Isabel Espinosa-Salinas Ricardo 11 Roberto Martín-Hernández Alberto Risueño 12 Javier De Las Rivas Guillermo Reglero Yaya 13 Carlos Fernández-Martos Jorge Aparicio 14 Joan Maurel 15 Jaime Feliu Ramírez de Molecular Oncology, IMDEA-Food Institute, CEI...
Metabolic reprogramming is one of cancer hallmarks. Here, we focus on functional differences and individual contribution acyl coA synthetases (ACSL) isoforms to the previously described ACSL/stearoyl-CoA desaturase (ACSL1/ACSL4/SCD) metabolic network causing invasion poor prognosis in colorectal (CRC). ACSL4 fuels proliferation migration accompanied by a more glycolytic phenotype. Conversely, ACSL1 stimulates displaying lower basal respiratory rate. Acylcarnitines elevation, polyunsaturated...
The increasing prevalence of diet-related diseases calls for an improvement in nutritional advice. Personalized nutrition aims to solve this problem by adapting dietary and lifestyle guidelines the unique circumstances each individual. With latest advances technology data science, researchers can now automatically collect analyze large amounts from a variety sources, including wearable smart devices. By combining these diverse data, more comprehensive insights human body its be achieved....
Current imaging modalities of atherosclerosis mainly visualize plaque morphology. Valuable insight into biology was achieved by visualizing enhanced metabolism in plaque-derived macrophages using 18F-fluorodeoxyglucose (18F-FDG). Similarly, uptake 18F-fluorocholine (18F-FCH) associated with surrounding an abscess. As are important determinants vulnerability, we tested 18F-FCH for imaging.We injected (n=5) or 18F-FDG intravenously atherosclerotic apolipoprotein E-deficient mice. En face...
An abnormal acyl-CoA synthetase/stearoyl-CoA desaturase (ACSL/SCD) lipid network fuels colon cancer progression, endowing cells with invasive and migratory properties. Therapies against this metabolic may be useful to improve clinical outcomes. Because micro-RNAs (miRNAs/miRs) are important epigenetic regulators, we investigated novel miRNAs targeting pro-tumorigenic axis; hence used as therapeutic or prognostic miRNAs. Thirty-one putative common were predicted simultaneously target the...