A5023065458- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Circular RNAs in diseases
- Barrier Structure and Function Studies
- Immune Response and Inflammation
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Effects of Radiation Exposure
- Cancer, Stress, Anesthesia, and Immune Response
- Cell Adhesion Molecules Research
- Gut microbiota and health
- Microscopic Colitis
- Neurological Disease Mechanisms and Treatments
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Inflammatory mediators and NSAID effects
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2014-2024
Universitat de Barcelona
2006-2024
Institut d'Investigacions Biomèdiques de Barcelona
2003-2024
Consejo Superior de Investigaciones Científicas
2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2012-2021
Hospital Clínic de Barcelona
2006-2021
Instituto de Salud Carlos III
2021
American College of Gastroenterology
2019
Aix-Marseille Université
2007-2015
Centre National de la Recherche Scientifique
2013-2015
Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear 1 ( TP53INP1 ) proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that expression dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and decrease occurs early during development. reexpression the cancer-derived cell line MiaPaCa2 strongly its capacity to form s.c., i.p., intrapancreatic tumors nude mice. This anti-tumoral is, at...
Abstract Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is especial interest to set new strategies aimed at improving prognostic this deadly disease. The present study was undertaken investigate action cannabinoids, a family potential antitumoral agents, in pancreatic cancer. We show that cannabinoid receptors expressed human tumor cell lines and biopsies much higher levels than normal tissue. Studies conducted with MiaPaCa2 Panc1 showed...
Abstract Oxidant stress has been implicated in the pathogenesis of inflammatory bowel disease. Antioxidant enzymes, such as superoxide dismutase (SOD), are candidate drugs for modulating this pathogenic factor. This study was designed to determine therapeutic value SOD an experimental model colitis and mechanisms underlying its effects on intestinal inflammation. For that purpose, colitic (trinitrobenzene sulfonic acid-induced) control rats were studied. Groups animals treated with different...
microRNAs (miRNA) are small noncoding transcripts that play an important role in carcinogenesis. miRNA expression profiles have been shown to discriminate between different types of cancers. The aim this study was analyze global signatures various groups colorectal cancers (CRC) based on the presence microsatellite instability (MSI).We analyzed genome-wide 54 CRC tissues [22 with Lynch syndrome, 13 sporadic MSI due MLH1 methylation, 19 without (or stable, MSS)] and 20 normal colonic by...
OBJECTIVES: Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising biomarkers for colorectal cancer (CRC) screening. In this study, we investigated performance a specific signature miRNA plasma samples to design robust predictive model that distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases. METHODS: Case...
To evaluate the effect of low molecular weight heparin on plasma xanthine oxidase concentrations and lung inflammatory response during acute pancreatitis.Randomized, controlled trial.Experimental laboratory.Male Wistar rats.Acute pancreatitis was induced by intraductal administration 5% sodium taurocholate. Low (0, 30, 90, or 300 units/kg) administered immediately after induction pancreatitis.Lipase were measured 3 hrs induction. Expression P-selectin messenger RNA myeloperoxidase activity...
<h3>Objective:</h3> <i>Yersinia pseudotuberculosis</i> causes ileitis and mesenteric lymphadenitis by mainly invading the Peyer's patches that are positioned in terminal ileum. Whereas toll-like-receptor 2 (TLR2) controls mucosal inflammation detecting certain microbiota-derived signals, its exact role protecting against bacterial invasion has not been defined. <h3>Design:</h3> Wild-type, <i>Tlr2</i>-, <i>Nod2</i>- <i>MyD88</i>-deficient animals were challenged <i>Y via oral or systemic...
// Teodoro Vargas 1 , Juan Moreno-Rubio 2, 3 Jesús Herranz 4 Paloma Cejas 5 Susana Molina Margarita González-Vallinas Marta Mendiola 2 Emilio Burgos 5, 6 Cristina Aguayo 7 Ana B. Custodio Isidro Machado 8 David Ramos 9 Meritxell Gironella 10 Isabel Espinosa-Salinas Ricardo 11 Roberto Martín-Hernández Alberto Risueño 12 Javier De Las Rivas Guillermo Reglero Yaya 13 Carlos Fernández-Martos Jorge Aparicio 14 Joan Maurel 15 Jaime Feliu Ramírez de Molecular Oncology, IMDEA-Food Institute, CEI...
Posttreatment recurrence of colorectal cancer, the third most lethal cancer worldwide, is often driven by a subpopulation stem cells (CSC). The tight junction (TJ) protein claudin-2 overexpressed in human where it enhances cell proliferation, colony formation, and chemoresistance vitro While several these biological processes are features CSC phenotype, role for regulation has not been identified. Here, we report that elevated expression stage II/III tumors associated with poor...
Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumour with poor prognosis using current treatments. Targeted therapies may offer new avenue for more effective strategies. Dual-specificity tyrosine regulated kinase 1A (DYRK1A) pleiotropic contradictory roles in different tumours that uncharacterised PDAC. Here, we aimed to investigate the role of DYRK1A pancreatic tumorigenesis. Design We analysed expression PDAC genetic mouse models patient samples. function...
Cerebral ischemia triggers an inflammatory process involving the infiltration of leukocytes to parenchyma. Circulating adhere vascular wall through adhesion molecules. Here we quantified in vivo expression cell molecule-1 (VCAM-1) brain, heart and lungs from 6 48 h after transient middle cerebral artery (MCA) occlusion rats, by intravenous injection a tracer radiolabelled anti-VCAM-1 antibody. The localization VCAM-1 was verified immunohistochemistry Vascular strongly induced (4-fold at 24...
Increased pancreatitis associated protein (PAP) mRNA has been reported in active inflammatory bowel disease (IBD). The aims of the current study were to characterise PAP production IBD and effects on inflammation.Serum levels determined healthy controls (n = 29), 14), patients 171). Ex vivo secretion intestinal tissue was measured 56 13 controls. Cellular origin by immunohistochemistry. exogenous nuclear factor kappaB (NFkappaB) activation, proinflammatory cytokine production, endothelial...
Gemcitabine is the only available chemotherapeutic treatment of pancreatic cancers. It is, however, moderately effective, showing a tumor response rate 12%. The aim this work was to identify new pathways involved in resistance cancer cells gemcitabine, hope developing adjuvant strategies enhance its therapeutic efficacy. Comparison gene expression patterns five human cell lines different degrees gemcitabine revealed specific overexpression several genes most resistant. One them encoded...
Tumor protein 53-induced nuclear 1 (TP53INP1) is an antiproliferative and proapoptotic involved in cell stress response. To address its physiological roles colorectal cancer colitis, we generated tested the susceptibility of Trp53inp1-deficient mice to development tumors induced by injection carcinogen azoxymethane followed dextran sulfate sodium (DSS)-induced chronic colitis. showed increased incidence multiplicity compared those wild-type (WT) mice. Furthermore, acute colitis DSS treatment...
PAP/HIP was first reported as an additional pancreatic secretory protein expressed during the acute phase of pancreatitis. It shown in vitro to be anti-apoptotic and anti-inflammatory. This study aims look at whether plays same role vivo.A model caerulein-induced pancreatitis used compare outcome PAP/HIP(-/-) wild-type mice.PAP/HIP(-/-) mice showed normal phenotype birth postnatal development. Caerulein-induced necrosis was, however, less severe than mice, judged by lower amylasemia...
Objective: The aim of our study was to analyze the miRNome pancreatic ductal adenocarcinoma (PDAC) and its preneoplastic lesion intraductal papillary mucinous neoplasm (IPMN), find new microRNA (miRNA)-based biomarkers for early detection neoplasia. Effective methods PDAC are needed. miRNAs good biomarker candidates. Methods: Pancreatic tissues (n = 165) were obtained from patients with PDAC, IPMN, or control individuals (C), Hospital Clínic Barcelona. Biomarker discovery done using...
OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) presents the lowest survival rate of all cancers because only 6% patients reach five-year survival. Alterations in expression several microRNAs (miRNAs) occur tumor PDAC and preneoplastic lesions as called intraductal papillary mucinous neoplasm (IPMN). Here, we aimed at identifying which miRNAs are significantly altered liquid biopsies from with IPMN to find new noninvasive biomarkers for early detection PDAC. METHODS: We analyzed by...
The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities thereby enhanced or repressed. In this work we describe another example such mechanism, by which binds negatively regulates MSL1, histone acetyl transferase (HAT)-associated protein, in turn the DNA-damage-associated 53BP1 to facilitate DNA repair following gamma-irradiation. Contrary...