Arif B. Ekici

ORCID: 0000-0001-6099-7066
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Research Areas
  • BRCA gene mutations in cancer
  • Genetic Associations and Epidemiology
  • Ovarian cancer diagnosis and treatment
  • Cancer-related molecular mechanisms research
  • Genomic variations and chromosomal abnormalities
  • RNA modifications and cancer
  • Epigenetics and DNA Methylation
  • RNA Research and Splicing
  • Estrogen and related hormone effects
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • Endometrial and Cervical Cancer Treatments
  • Nutrition, Genetics, and Disease
  • Genomics and Chromatin Dynamics
  • Immune Cell Function and Interaction
  • Genetics and Neurodevelopmental Disorders
  • Bioinformatics and Genomic Networks
  • MicroRNA in disease regulation
  • Cytokine Signaling Pathways and Interactions
  • Reproductive System and Pregnancy
  • Chronic Kidney Disease and Diabetes
  • Renal Diseases and Glomerulopathies
  • Genomics and Rare Diseases
  • IL-33, ST2, and ILC Pathways
  • Cancer Risks and Factors

Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025

Comprehensive Cancer Center Erlangen
2014-2024

Universitätsklinikum Erlangen
2015-2024

Bayer (Germany)
2021-2023

University of Regensburg
2010-2023

Innsbruck Medical University
2014-2023

Charité - Universitätsmedizin Berlin
2021-2023

RWTH Aachen University
2023

Medizinische Hochschule Hannover
2023

Jena University Hospital
2023

Kyriaki Michailidou Sara Lindström Joe Dennis Jonathan Beesley Shirley Hui and 95 more Siddhartha Kar Audrey Lemaçon Penny Soucy Dylan M. Glubb Asha Rostamianfar Manjeet K. Bolla Qin Wang Jonathan P. Tyrer Ed Dicks Andrew Lee Zhaoming Wang Jamie Allen Renske Keeman Ursula Eilber Juliet D. French Xiaohong Chen Laura Fachal Karen McCue Amy E. McCart Reed Maya Ghoussaini Jason S. Carroll Xia Jiang Hilary K. Finucane Marcia Adams Muriel A. Adank Habibul Ahsan Kristiina Aittomäki Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Banu K. Arun Paul L. Auer François Bacot Myrto Barrdahl Caroline Baynes Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Paul Brennan Hermann Brenner Louise A. Brinton Per Broberg Ian W. Brock Annegien Broeks Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Katja Butterbach Qiuyin Cai Hui Cai Trinidad Caldés Federico Canzian Ángel Carracedo Brian D. Carter Jose E. Castelao Tsun Leung Chan Ting‐Yuan David Cheng Kee Seng Chia Ji‐Yeob Choi Hans Christiansen Christine L. Clarke Margriet Collée Don Conroy Emilie Cordina‐Duverger Sten Cornelissen David G. Cox Angela Cox Simon S. Cross Julie M. Cunningham Kamila Czene Mary B. Daly Peter Devilee Kimberly F. Doheny Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Mingajeva Elvira Christoph Engel

10.1038/nature24284 article EN Nature 2017-10-20
Nasim Mavaddat Kyriaki Michailidou Joe Dennis Michael Lush Laura Fachal and 95 more Andrew Lee Jonathan P. Tyrer Ting‐Huei Chen Qin Wang Manjeet K. Bolla Xin Yang Muriel A. Adank Thomas U. Ahearn Kristiina Aittomäki Jamie Allen Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Paul L. Auer Päivi Auvinen Myrto Barrdahl Laura E. Beane Freeman Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Hiltrud Brauch Michael Bremer Hermann Brenner Adam R. Brentnall Ian W. Brock Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Daniele Campa Brian D. Carter Jose E. Castelao Stephen J. Chanock Rowan T. Chlebowski Hans Christiansen Christine L. Clarke J. Margriet Collée Emilie Cordina‐Duverger Sten Cornelissen Fergus J. Couch Angela Cox Simon S. Cross Kamila Czene Mary B. Daly Peter Devilee Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Jonine D. Figueroa Olivia Fletcher Henrik Flyger Asta Försti Lin Fritschi Marike Gabrielson Manuela Gago‐Dominguez Susan M. Gapstur José Á. García-Sáenz Mia M. Gaudet V. Georgoulias Graham G. Giles I. R. Gilyazova Gord Glendon Mark S. Goldberg David E. Goldgar Anna González‐Neira Grethe I.G. Alnæs Mervi Grip Jacek Gronwald Anne Grundy Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A. Haiman Niclas Håkansson Ute Hamann Susan E. Hankinson

Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...

10.1016/j.ajhg.2018.11.002 article EN cc-by-nc-nd The American Journal of Human Genetics 2018-12-13
Ganna Chornokur Hui‐Yi Lin Jonathan P. Tyrer Kate Lawrenson Joe Dennis and 95 more Ernest K. Amankwah Xiaotao Qu Ya-Yu Tsai Heather Jim Zhihua Chen Y. Ann Chen Jennifer Permuth‐Wey Katja K.H. Aben Hoda Anton‐Culver Natalia Antonenkova Fiona Bruinsma Elisa V. Bandera Yukie T. Bean Matthias W. Beckmann Maria Bisogna Line Bjørge Natalia Bogdanova Louise A. Brinton Angela Brooks‐Wilson Clareann H. Bunker Ralf Bützow Ian Campbell Karen Carty Jenny Chang‐Claude Linda S. Cook Daniel W. Cramer Julie M. Cunningham Cezary Cybulski Agnieszka Dansonka‐Mieszkowska Andreas du Bois Evelyn Despierre Ed Dicks Jennifer A. Doherty Thilo Dörk Matthias Dürst Douglas F. Easton Diana Eccles Robert P. Edwards Arif B. Ekici Peter A. Fasching Brooke L. Fridley Yu‐Tang Gao Aleksandra Gentry‐Maharaj Graham G. Giles Rosalind Glasspool Marc T. Goodman Jacek Gronwald Patricia Harrington Philipp Harter Alexander Hein Florian Heitz Michelle A.T. Hildebrandt Peter Hillemanns Claus Høgdall Estrid Høgdall Satoyo Hosono Anna Jakubowska Allan Jensen Bu‐Tian Ji Beth Y. Karlan Linda E. Kelemen Mellissa Kellar Lambertus A. Kiemeney Camilla Krakstad Susanne K. Kjær Jolanta Kupryjańczyk Diether Lambrechts Sandrina Lambrechts Nhu D. Le Alice W. Lee Shashi Lele Arto Leminen Jenny Lester Douglas A. Levine Dong Liang Boon Kiong Lim Jolanta Lissowska Karen H. Lu Jan Lubiński Lene Lundvall Leon F.A.G. Massuger Keitaro Matsuo Valerie McGuire Esther M. John Iain A. McNeish Usha Menon Roger L. Milne Francesmary Modugno Kirsten B. Moysich Roberta B. Ness Heli Nevanlinna Ursula Eilber Kunle Odunsi Sara H. Olson Irene Orlow

Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...

10.1371/journal.pone.0128106 article EN cc-by PLoS ONE 2015-06-19
Leila Dorling Sara Carvalho Jamie Allen Anna González‐Neira Craig Luccarini and 95 more Cecilia Wahlström Karen A. Pooley Michael T. Parsons Cristina Fortuño Qin Wang Manjeet K. Bolla Joe Dennis Renske Keeman M. Rosario Alonso Núria Álvarez Belén Herráez María Victoria Fernández Rocío Núñez‐Torres Ana Osório Jeanette Valcich Minerva Li Therese Törngren Patricia Harrington Caroline Baynes Don Conroy Brennan Decker Laura Fachal Nasim Mavaddat Thomas U. Ahearn Kristiina Aittomäki Natalia Antonenkova Norbert Arnold Patrick Arveux Margreet G.E.M. Ausems Päivi Auvinen Heiko Becher Matthias W. Beckmann Sabine Behrens Marina Bermisheva Katarzyna Białkowska Carl Blomqvist Natalia Bogdanova Nadja Bogdanova-Markov Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Hiltrud Brauch Michael Bremer Ignacio Briceño Thomas Brüning Barbara Burwinkel David Cameron Nicola J. Camp Archie Campbell Ángel Carracedo Jose E. Castelao Melissa H. Cessna Stephen J. Chanock Hans Christiansen J. Margriet Collée Emilie Cordina‐Duverger Sten Cornelissen Kamila Czene Thilo Dörk Arif B. Ekici Christoph Engel Mikael Eriksson Peter A. Fasching Jonine D. Figueroa Henrik Flyger Asta Försti Marike Gabrielson Manuela Gago‐Dominguez V. Georgoulias Fabián Gil Graham G. Giles Gord Glendon E. Gómez Grethe I.G. Alnæs Pascal Guénel Andreas Hadjisavvas Lothar Haeberle Eric Hahnen Per Hall Ute Hamann Elaine F. Harkness Jaana M. Hartikainen Mikael Hartman Wei He Bernadette A. M. Heemskerk‐Gerritsen Peter Hillemanns Frans B.L. Hogervorst Antoinette Hollestelle Weang-Kee Ho Maartje J. Hooning Anthony Howell Keith Humphreys Faiza Idris Anna Jakubowska Audrey Jung

Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.

10.1056/nejmoa1913948 article EN New England Journal of Medicine 2021-01-20
Sofia Khan Dario Greco Kyriaki Michailidou Roger L. Milne Taru Muranen and 95 more Tuomas Heikkinen Kirsimari Aaltonen Joe Dennis Manjeet K. Bolla Jianjun Liu Per Hall Astrid Irwanto Keith Humphreys Jingmei Li Kamila Czene Jenny Chang‐Claude Rebecca Hein Anja Rudolph Petra Seibold Dieter Flesch‐Janys Olivia Fletcher Julian Peto Isabel dos‐Santos‐Silva Nichola Johnson Lorna J. Gibson Zoe Aitken John L. Hopper Helen Tsimiklis Minh Bui Enes Makalic Daniel F. Schmidt Melissa C. Southey Carmel Apicella Jennifer Stone Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner Clare Turnbull Nazneen Rahman Stephen J. Chanock David J. Hunter Angela Cox Simon S. Cross Malcolm Reed Marjanka K. Schmidt Annegien Broeks Laura J. V. a. n't. Veer Frans B.L. Hogervorst Peter A. Fasching Michael Schrauder Arif B. Ekici Matthias W. Beckmann Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Javier Benı́tez Pilar Zamora José Ignacio Arias Pérez Christopher A. Haiman Brian E. Henderson Fredrick R. Schumacher Loı̈c Le Marchand Paul D.P. Pharoah Alison M. Dunning Mitul Shah Robert Luben Judith Brown Fergus J. Couch Xianshu Wang Celine M. Vachon Janet E. Olson Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Pascal Guénel Thérèse Truong Pierre Laurent‐Puig Claire Mulot F. Marmé Barbara Burwinkel Andreas Schneeweiß Christof Sohn Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Irene L. Andrulis Julia A. Knight Sandrine Tchatchou Anna Marie Mulligan Thilo Dörk Natalia Bogdanova Natalia Antonenkova

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...

10.1371/journal.pone.0109973 article EN cc-by PLoS ONE 2014-11-12

Purpose Recent advances in DNA sequencing have led to the development of breast cancer susceptibility gene panels for germline genetic testing patients. We assessed frequency mutations 17 predisposition genes, including BRCA1 and BRCA2, a large cohort patients with triple-negative (TNBC) unselected family history or ovarian determine utility those TNBC. Patients Methods TNBC (N = 1,824) were recruited through 12 studies, was sequenced identify mutations. Results Deleterious identified 14.6%...

10.1200/jco.2014.57.1414 article EN Journal of Clinical Oncology 2014-12-02
Nasim Mavaddat Paul D.P. Pharoah Kyriaki Michailidou Jonathan P. Tyrer Mark N. Brook and 95 more Manjeet K. Bolla Qin Wang Joe Dennis Alison M. Dunning Mitul Shah Robert Luben Judith Brown Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Kamila Czene Hatef Darabi Mikael Eriksson Julian Peto Isabel dos‐Santos‐Silva Frank Dudbridge Nichola Johnson Marjanka K. Schmidt Annegien Broeks Senno Verhoef Emiel J. Rutgers Anthony J. Swerdlow Alan Ashworth Nick Orr Minouk J. Schoemaker Jonine D. Figueroa Stephen J. Chanock Louise A. Brinton Jolanta Lissowska Fergus J. Couch Janet E. Olson Celine M. Vachon V. Shane Pankratz Diether Lambrechts Hans Wildiers Chantal Van Ongeval Erik Van Limbergen Vessela Kristensen Grethe Grenaker Alnæs Silje Nord Anne‐Lise Børresen‐Dale Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Jenny Chang‐Claude Anja Rudolph Petra Seibold Dieter Flesch‐Janys Peter A. Fasching Lothar Haeberle Arif B. Ekici Matthias W. Beckmann Barbara Burwinkel Frederik Marmé Andreas Schneeweiß Christof Sohn Amy Trentham‐Dietz Polly A. Newcomb Linda Titus Kathleen M. Egan David J. Hunter Sara Lindström Rulla M. Tamimi Peter Kraft Nazneen Rahman Clare Turnbull Anthony Renwick Sheila Seal Jingmei Li Jianjun Liu Keith Humphreys Javier Benı́tez M. Pilar Zamora José Ignacio Arias Pérez Primitiva Menéndez Anna Jakubowska Jan Lubiński Katarzyna Jaworska–Bieniek Katarzyna Durda Natalia Bogdanova Natalia Antonenkova Thilo Dörk Hoda Anton‐Culver Susan L. Neuhausen Argyrios Ziogas Leslie Bernstein Peter Devilee Robert A.E.M. Tollenaar Caroline Seynaeve Christi J. van Asperen Angela Cox Simon S. Cross Malcolm Reed

Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...

10.1093/jnci/djv036 article EN cc-by JNCI Journal of the National Cancer Institute 2015-04-02
Loïc Yengo Sailaja Vedantam Eirini Marouli Julia Sidorenko Eric Bartell and 95 more Saori Sakaue Marielisa Graff Anders U. Eliasen Yunxuan Jiang Sridharan Raghavan Jenkai Miao Joshua Arias Sarah E. Graham Ronen E. Mukamel Cassandra N. Spracklen Xianyong Yin Shyh‐Huei Chen Teresa Ferreira Heather H Highland Yingjie Ji Tugce Karaderi Kuang Lin Kreete Lüll Deborah E. Malden Carolina Medina‐Gómez Moara Machado Amy Moore Sina Rüeger Xueling Sim Scott Vrieze Tarunveer S. Ahluwalia Masato Akiyama Matthew Allison Marcus Alvarez Mette K. Andersen Alireza Ani Vivek Appadurai Liubov Arbeeva Seema Bhaskar Lawrence F. Bielak Sailalitha Bollepalli Lori L. Bonnycastle Jette Bork‐Jensen Jonathan P. Bradfield Yuki Bradford Peter S. Braund Jennifer A. Brody Kristoffer Sølvsten Burgdorf Brian E. Cade Hui Cai Qiuyin Cai Archie Campbell Marisa Cañadas‐Garre Eulalia Catamo Jin Fang Chai Xiaoran Chai Li-Ching Chang Yi–Cheng Chang Chien-Hsiun Chen Alessandra Chesi Seung Hoan Choi Ren‐Hua Chung Massimiliano Cocca Maria Pina Concas Christian Couture Gabriel Cuéllar-Partida Rebecca Danning E. Warwick Daw Frauke Degenhard Graciela E. Delgado Alessandro Delitala Ayşe Demirkan Xuan Deng Poornima Devineni Alexander Dietl Maria Dimitriou Latchezar Dimitrov Rajkumar Dorajoo Arif B. Ekici Jorgen Engmann Zammy Fairhurst-Hunter Aliki‐Eleni Farmaki Jessica D. Faul Juan-Carlos Fernandez-Lopez Lukas Forer Margherita Francescatto Sandra Freitag‐Wolf Christian Fuchsberger Tessel E. Galesloot Yan Gao Zishan Gao Frank Geller Olga Giannakopoulou Franco Giulianini Anette P. Gjesing Anuj Goel Scott D. Gordon Mathias Gorski Jakob Grove Xiuqing Guo

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes

10.1038/s41586-022-05275-y article EN cc-by Nature 2022-10-12
Montserrat García‐Closas Fergus J. Couch Sara Lindström Kyriaki Michailidou Marjanka K. Schmidt and 95 more Mark N. Brook Nick Orr Suhn K. Rhie Elio Ríboli Heather Spencer Feigelson Loı̈c Le Marchand Julie E. Buring Diana Eccles Penelope Miron Peter A. Fasching Hiltrud Brauch Jenny Chang‐Claude Jane Carpenter Andrew K. Godwin Heli Nevanlinna Graham G. Giles Angela Cox John L. Hopper Manjeet K. Bolla Qin Wang Joe Dennis Ed Dicks Will J Howat Nils Schoof Stig E. Bojesen Diether Lambrechts Annegien Broeks Irene L. Andrulis Pascal Guénel Barbara Burwinkel Elinor J. Sawyer Antoinette Hollestelle Olivia Fletcher Robert Winqvist Hermann Brenner Graham J. Mann Ute Hamann Alfons Meindl Annika Lindblom Wei Zheng Peter Devillee Mark S. Goldberg Jan Lubiński Vessela N. Kristensen Anthony J. Swerdlow Hoda Anton‐Culver Thilo Dörk Kenneth Muir Keitaro Matsuo Anna H. Wu Paolo Radice Soo‐Hwang Teo Xiao‐Ou Shu William J. Blot Daehee Kang Mikael Hartman Suleeporn Sangrajrang Chen‐Yang Shen Melissa C. Southey Daniel J. Park Fleur Hammet Jennifer Stone Laura J. van’t Veer Emiel J. Rutgers Artitaya Lophatananon Sarah Stewart‐Brown Pornthep Siriwanarangsan Julian Peto Michael Schrauder Arif B. Ekici Matthias W. Beckmann Isabel dos‐Santos‐Silva Nichola Johnson Helen R. Warren Ian Tomlinson Michael J. Kerin Nicola Miller F Marmé Andreas Schneeweiß Christof Sohn Thérèse Truong Pierre Laurent–Puig Pierre Kerbrat Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Roger L. Milne José Ignacio Arias Pérez Primitiva Menéndez Heiko Müller Volker Arndt Christa Stegmaier Peter Lichtner Magdalena Lochmann Christina Justenhoven

10.1038/ng.2561 article EN Nature Genetics 2013-03-27

Fundamental processes influencing human growth can be revealed by studying extreme short stature. Using genetic linkage analysis, we find that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II) 25 patients. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to 3-month-old baby, but are near-normal...

10.1126/science.1151174 article EN Science 2008-01-04
Paul D.P. Pharoah Ya-Yu Tsai Susan J. Ramus Catherine M. Phelan Ellen L. Goode and 95 more Kate Lawrenson Melissa A. Buckley Brooke L. Fridley Jonathan P. Tyrer Howard C. Shen Rachel Palmieri Weber Rod Karevan Melissa C. Larson Honglin Song Daniel C. Tessier François Bacot Daniel Vincent Julie M. Cunningham Joe Dennis Ed Dicks Katja K.H. Aben Hoda Anton‐Culver Natalia Antonenkova Sebastian M. Armasu Laura Baglietto Elisa V. Bandera Matthias W. Beckmann Michael J. Birrer Greg Bloom Natalia Bogdanova James D. Brenton Louise A. Brinton Angela Brooks‐Wilson Robert Brown Ralf Bützow Ian Campbell Michael E. Carney Renato S. Carvalho Jenny Chang‐Claude Y Anne Chen Zhihua Chen Wong‐Ho Chow Mine Cicek Gerhard A. Coetzee Linda S. Cook Daniel W. Cramer Cezary Cybulski Agnieszka Dansonka‐Mieszkowska Evelyn Despierre Jennifer A. Doherty Thilo Dörk Andreas du Bois Matthias Dürst Diana Eccles Robert P. Edwards Arif B. Ekici Peter A. Fasching David Fenstermacher James M. Flanagan Yu-Tang Gao Montserrat García‐Closas Aleksandra Gentry‐Maharaj Graham G. Giles Anxhela Gjyshi Martin Gore Jacek Gronwald Qi Guo Mari K. Halle Philipp Harter Alexander Hein Florian Heitz Peter Hillemanns Maureen E. Hoatlin Estrid Høgdall Claus Høgdall Satoyo Hosono Anna Jakubowska Allan Jensen Kimberly R. Kalli Beth Y. Karlan Linda E. Kelemen Lambertus A. Kiemeney Susanne K. Kjær Gottfried E. Konecny Camilla Krakstad Jolanta Kupryjańczyk Diether Lambrechts Sandrina Lambrechts Nhu D. Le Nathan Lee Janet Lee Arto Leminen Boon Kiong Lim Jolanta Lissowska Jan Lubiński Lene Lundvall Galina Lurie Leon F.A.G. Massuger Keitaro Matsuo Valerie McGuire

10.1038/ng.2564 article EN Nature Genetics 2013-03-27
Christopher A. Haiman Gary K. Chen Celine M. Vachon Federico Canzian Alison M. Dunning and 95 more Robert C. Millikan Xianshu Wang Foluso O. Ademuyiwa Shahana Ahmed Christine B. Ambrosone Laura Baglietto Rosemary L. Balleine Elisa V. Bandera Matthias W. Beckmann Christine D. Berg Leslie Bernstein Carl Blomqvist William J. Blot Hiltrud Brauch Julie E. Buring Lisa A. Carey Jane Carpenter Jenny Chang‐Claude Stephen J. Chanock Daniel I. Chasman Christine L. Clarke Angela Cox Simon S. Cross Sandra L. Deming Robert B. Diasio Meletios Α. Dimopoulos W. Ryan Driver Thomas Dünnebier Lorraine Durcan Diana Eccles Christopher K. Edlund Arif B. Ekici Peter A. Fasching Heather Spencer Feigelson Dieter Flesch‐Janys Florentia Fostira Asta Försti George Fountzilas Susan M. Gerty Graham G. Giles Andrew K. Godwin Paul J. Goodfellow Nikki Graham Dario Greco Ute Hamann Susan E. Hankinson Arndt Hartmann Rebecca Hein Judith Heinz Andrea Holbrook Robert N. Hoover Jennifer J. Hu David J. Hunter Sue A. Ingles Astrid Irwanto Jennifer Ivanovich Esther M. John Nicola Johnson Arja Jukkola‐Vuorinen Rudolf Kaaks Yon‐Dschun Ko Laurence N. Kolonel Irene Konstantopoulou Veli-Matti Kosma Swati Kulkarni Diether Lambrechts Adam M. Lee Loı̈c Le Marchand Timothy G. Lesnick Jianjun Liu Sara Lindström Graham J. Mann Sara Margolin Nicholas G. Martin Penelope Miron Grant W. Montgomery Heli Nevanlinna Stephan Nickels Sarah J. Nyante Curtis Olswold Julie R. Palmer Harsh B. Pathak Dimitrios Pectasides Charles M. Perou Julian Peto Paul D.P. Pharoah Loreall Pooler Michael F. Press Katri Pylkäs Timothy R. Rebbeck Jorge L. Rodriguez‐Gil Lynn Rosenberg Eric A. Ross Thomas Rüdiger Isabel dos‐Santos‐Silva

10.1038/ng.985 article EN Nature Genetics 2011-10-30

10.1038/ng.424 article EN Nature Genetics 2009-08-02
Tracy A. O’Mara Dylan M. Glubb Frédéric Amant Daniela Annibali Katie A. Ashton and 95 more John Attia Paul L. Auer Matthias W. Beckmann Amanda Black Manjeet K. Bolla Hiltrud Brauch Hermann Brenner Louise A. Brinton Daniel D. Buchanan Barbara Burwinkel Jenny Chang‐Claude Stephen J. Chanock Chu Chen Maxine M. Chen Timothy Cheng Christine L. Clarke Mark Clendenning Linda S. Cook Fergus J. Couch Angela Cox Marta Crous‐Bou Kamila Czene Felix R. Day Joe Dennis Jeroen Depreeuw Jennifer A. Doherty Thilo Dörk Sean C. Dowdy Matthias Dürst Arif B. Ekici Peter A. Fasching Brooke L. Fridley Christine M. Friedenreich Lin Fritschi Jenny N. Fung Montserrat García‐Closas Mia M. Gaudet Graham G. Giles Ellen L. Goode Maggie Gorman Christopher A. Haiman Per Hall Susan E. Hankison Catherine S. Healey Alexander Hein Peter Hillemanns Shirley Hodgson Erling A. Høivik Elizabeth Holliday John L. Hopper David J. Hunter Angela Jones Camilla Krakstad Vessela N. Kristensen Diether Lambrechts Loı̈c Le Marchand Xiaolin Liang Annika Lindblom Jolanta Lissowska Jirong Long Lingeng Lu Anthony M. Magliocco Lynn Martin Mark McEvoy Alfons Meindl Kyriaki Michailidou Roger L. Milne Miriam Mints Grant W. Montgomery Rami Nassir Håkan Olsson Irene Orlow Geoffrey Otton Claire Palles John R. B. Perry Julian Peto Loreall Pooler Jennifer Prescott Tony Proietto Timothy R. Rebbeck Harvey A. Risch Peter A. W. Rogers Matthias Rübner Ingo B. Runnebaum Carlotta Sacerdote Gloria E. Sarto Fredrick R. Schumacher Rodney J. Scott Veronica Wendy Setiawan Mitul Shah Xin Sheng Xiao‐Ou Shu Melissa C. Southey Anthony J. Swerdlow Emma Tham

Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...

10.1038/s41467-018-05427-7 article EN cc-by Nature Communications 2018-08-03
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