Ya-Yu Tsai
A5048825007- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
- Molecular Biology Techniques and Applications
- Melanoma and MAPK Pathways
- Mitochondrial Function and Pathology
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Microtubule and mitosis dynamics
- Hormonal Regulation and Hypertension
- Palliative Care and End-of-Life Issues
- Plant-Derived Bioactive Compounds
Moffitt Cancer Center
2016-2025
Cleveland Clinic Lerner College of Medicine
2024-2025
Cerner (United States)
2025
Cleveland Clinic
2021-2025
Zunyi Medical University
2024
South China University of Technology
2024
University of South Florida
2018-2023
82th Hospital of Pla
2020
GTx (United States)
2016
University of Glasgow
2016
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
The initial report of NRG Oncology/Radiation Therapy Oncology Group (RTOG) 0424 demonstrated a 3-year overall survival benefit with the addition temozolomide to radiotherapy compared historical control. However, an important end point trial-evaluation association between O6-methylgaunine-DNA-methyltransferase (MGMT) promoter methylation and outcomes-was not previously reported.To examine proportion patients in Oncology/RTOG MGMT its outcomes.Specimens collected were analyzed after trial...
This phase II study was designed to determine the efficacy of mammalian target rapamycin (mTOR) inhibitor everolimus administered daily with conventional radiation therapy and chemotherapy in patients newly diagnosed glioblastoma.Patients were randomized concurrent adjuvant temozolomide or without (10 mg). The primary endpoint progression-free survival (PFS) secondary endpoints overall (OS) treatment-related toxicities.A total 171 deemed eligible for this study. Patients receive experienced...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized the 3′ untranslated region at putative microRNA (miRNA)-binding sites represent functional targets influence EOC susceptibility. Here, we evaluate association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and risk 18,174 cases 26,134 controls from 43 studies genotyped through...
Radiotherapy may synergize with programmed cell death 1 (PD1)/PD1 ligand (PD-L1) blockade. The purpose of this study was to determine the recommended phase II dose, safety/tolerability, and preliminary efficacy combining pembrolizumab, an anti-PD1 monoclonal antibody, hypofractionated stereotactic irradiation (HFSRT) bevacizumab in patients recurrent high-grade gliomas (HGGs).Eligible subjects glioblastoma or anaplastic astrocytoma were treated pembrolizumab (100 200 mg based on dose level...
A phase I study was conducted to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) for combination of vorinostat with bevacizumab CPT-11 in recurrent glioblastoma. Vorinostat combined escalated using a standard 3 + design. up 2 actively investigated doses this compound or until MTD identified on basis DLTs. Correlative science involving proteomic profiling serial patient plasma samples performed. Nineteen patients were treated. The established at 400 mg days 1-7...
The incidence of colorectal cancer (CRC) among individuals younger than age 50 (early-onset CRC [EOCRC]) has substantially increased, and yet the etiology molecular mechanisms underlying this alarming rise remain unclear. We compared tumor-associated T-cell repertoires between EOCRC average-onset (AOCRC) to uncover potentially unique immune microenvironment-related features by onset. Our discovery cohort included 242 patients who underwent surgical resection at Cleveland Clinic from 2000...
283 Background: Males have increased risk and mortality rates of colorectal cancer (CRC) compared to females, but the reasons for these disparities are not well understood. Immune responses differ by sex, a robust T cell response is an important prognostic indicator in CRC. We hypothesized that females exhibit stronger CRC-associated response, contributing reduced males. Methods: The study cohort included 2,751 incident CRC patients (1,337 female; 1,414 male) from population-based...
Abstract Background Our previous clinical investigation suggested that hypofractionated stereotactic re-irradiation (HFSRT) and PD-1 blockade may act synergistically to enhance the immune response against glioma. This subsequent trial investigated dual of CTLA4 in combination with HFSRT bevacizumab. Methods phase I study enrolled eligible patients bevacizumab-naïve recurrent glioblastoma or anaplastic astrocytoma. Participants received nivolumab, ipilimumab bevacizumab concurrently (3000 cGy...
Pancreatic cancer rarely metastasizes to the brain or meninges. Here, we describe a case in which patient developed both. Our patient, 75-year-old male individual, was diagnosed with pancreatic tumor on computed tomography (CT) of abdomen and pelvis after presenting for abdominal pain. The underwent an endoscopic ultrasound-guided fine needle aspiration mass pathology consistent adenocarcinoma pancreas. A positron emission (PET) scan showed metabolically active head mass, retroperitoneal...
Abstract Background Addressing critical gaps in precision medicine initiatives colorectal cancer (CRC) requires building larger collaborative studies. Methods The Latino Colorectal Cancer Consortium (LC3) is a resource that harmonizes data collected observational studies with from individuals who identify as Hispanic/Latino diagnosis of primary adenocarcinoma. Data includes demographics, medical history, family and lifestyle risk factors patient-completed surveys. Vital status, cause death,...
Abstract Background Due to recent concerns about the toxicity of trastuzumab emtansine ( T-DM1) with stereotactic radiation, we assessed our institutional outcomes treating HER2-positive breast cancer brain metastases (BCBM) T-DM1 and radiation. Methods This is a single institution series 16 patients who underwent 18 sessions 40 BCBM from 2013 2019 delivered within 6 months. The Kaplan-Meier method was used calculate overall survival (OS), local control (LC), distant intracranial (DIC),...