A5035733934- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Total Knee Arthroplasty Outcomes
- Neuroblastoma Research and Treatments
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Diverse Educational Innovations Studies
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Ocular Oncology and Treatments
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- CNS Lymphoma Diagnosis and Treatment
- Management of metastatic bone disease
- Hip disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Sports injuries and prevention
- Global Education and Multiculturalism
- Cerebrospinal fluid and hydrocephalus
University of Ottawa
2017-2025
Ottawa Hospital
2022-2024
Moffitt Cancer Center
2024
Compound Semiconductor Centre (United Kingdom)
2024
Western University
2007-2023
Aberdeen Royal Infirmary
2018-2022
Raigmore Hospital
2020-2022
Hôpital Européen Georges-Pompidou
2021
Centre Hospitalier Universitaire de Saint-Étienne
2021
Centre Hospitalier Universitaire de Clermont-Ferrand
2021
PURPOSE To examine the rate and duration of response anaplastic oligodendrogliomas to a dose-escalated combination chemotherapy regimen consisting procarbazine, lomustine (CCNU), vincristine (PCV) evaluate side effects this treatment. METHODS In single-arm multicentered phase II study, patients with measurable, newly diagnosed or recurrent, contrast-enhancing were treated up six cycles PCV. Central pathology radiology review mandatory, rigorous criteria based on imaging used. RESULTS...
Purpose Concomitant temozolomide (TMZ)/radiotherapy followed by adjuvant TMZ has increased survival in patients with glioblastoma multiforme (GBM). However, few options are effective for who experience treatment failure. We conducted a multicenter, phase II study to assess the efficacy and safety of continuous dose-intense recurrent GBM. Patients Methods malignant glioma at progression after standard 150 200 mg/m 2 × 5 days 28-day cycle three or more cycles were stratified tumor type...
To review the outcomes of patients with low-grade glioma diagnosed by modern imaging and treated at a center where postponing radiotherapy was common practice.We reviewed records (age > or = 18 years) pathologically confirmed supratentorial fibrillary astrocytoma, oligodendroglioma, mixed regional cancer in Canada between 1979 1995.Median survival for entire group (N 167; mean age 40.6 10.5 years 5- 10-year rates 72% 50%, respectively. Median progression-free 4.9 50% 12%, Overall survivals...
Convection-enhanced delivery (CED) is a novel intracerebral drug technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet end points. Although may be due inactive or failure rigorously validate targets, authors previously demonstrated that catheter positioning plays major role in distribution using technique. The purpose of present work was retrospectively analyze expected based...
Object. The management of certain meningiomas the skull base and those involving dural venous sinuses remains a challenge. In recent reports it has been suggested that hydroxyurea chemotherapy can cause regression unresectable recurrent meningiomas. authors report their experience in using for treatment patients with or Methods. Hydroxyurea was administered at dosage approximately 20 mg/kg/day to 11 women nine men (median age 59 years, range 31–75 years) intracranial (12 basal, two...
✓ In a pilot study, two groups of patients with malignant glioma underwent sequential neuropsychological evaluations after successful tumor treatment. Group 1 included nine treated from 1981 to 1985; all received irradiation and eight chemotherapy. The baseline assessment was performed 63 months diagnosis, follow-up at irregular intervals over the next 3 7 years. Six in exhibited impairment on most measures baseline; subsequently, developed profound cognitive impairment. Initially, three...
✓ Interstitial irradiation is a promising treatment for malignant glioma. Longer than expected survival periods following of recurrent tumor have led to the use brachytherapy as an adjuvant treatment. The impact patient selection on data was studied among candidates this therapy. Consecutive, conventionally treated adults with newly diagnosed supratentorial tumors were identified retrospectively at center where experience glioma population-based. Based imaging and performance status, two...
Abstract We treated 3 patients with newly diagnosed aggressive oligodendroglioma chemotherapy prior to radiotherapy and observed responses. All had residual or progressive tumor following initial surgery. used a combination called PCV‐3 because recurrent anaplastic responds predictably this regimen. Chemotherapy for response induction followed by consolidation is feasible effective treatment tumor.
Abstract Background Ofranergene obadenovec (VB-111) is an anticancer viral therapy that demonstrated in a phase II study survival benefit for patients with recurrent glioblastoma (rGBM) who were primed VB-111 monotherapy was continued after progression concomitant bevacizumab. Methods This pivotal III randomized, controlled trial compared the efficacy and safety of upfront combination bevacizumab versus monotherapy. Patients randomized 1:1 to receive 1013 particles every 8 weeks 10 mg/kg 2...
The aim of this study was to compare the incidence anterior knee pain after antegrade tibial nailing using suprapatellar and infrapatellar surgical approaches.A total 95 patients with a fracture requiring an intramedullary nail were randomized treatment supra- or approach. Anterior assessed at four six months, one year postoperatively, Aberdeen Weightbearing Test - Knee (AWT-K) score visual analogue scale (VAS) for pain. AWT-K is objective patient-reported outcome measure that uses weight...
Background: The incidence of pulmonary embolism has been increasing, but its case-fatality rate is decreasing, suggesting a lesser severity illness. clinical importance patients with isolated to the subsegmental vessels unknown. Objective: To determine recurrent venous thromboembolism in managed without anticoagulation. Design: Multicenter prospective cohort study. (ClinicalTrials.gov: NCT01455818) Setting: Eighteen sites between February 2011 and 2021. Patients: Patients embolism....