A5073829217- Glioma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Cancer Cells and Metastasis
- Characterization and Applications of Magnetic Nanoparticles
- Advanced MRI Techniques and Applications
- RNA Research and Splicing
- Pituitary Gland Disorders and Treatments
- Galectins and Cancer Biology
- Surgical Simulation and Training
- Ultrasound and Hyperthermia Applications
- interferon and immune responses
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Fractures and Fixation Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
University of Pittsburgh
2003-2025
Neurological Surgery
2008-2025
University of Pittsburgh Medical Center
2004-2025
Icahn School of Medicine at Mount Sinai
2015-2025
UPMC Hillman Cancer Center
2023-2025
Mount Sinai Hospital
2024
UPMC Health System
2024
Mount Sinai Health System
2017-2022
Mount Sinai Beth Israel
2016-2022
Tisch Cancer Institute
2015-2020
New metallic magnetic nanoparticles with greater properties than current iron oxide (IONPs) of comparable size (10 nm) are described. The multifunctional iron-based NPs coated biocompatible carboxyl-terminated polyethylene glycol (see image) generate more effective local hyperthermia when subjected to an oscillating field and have a stronger MRI T2 shortening effect IONPs.
// Milota Kaluzova 1 , Alexandros Bouras Revaz Machaidze 1,3 and Costas G. Hadjipanayis 1,2 Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Emory, University, School Medicine, Winship Cancer Institute Emory Atlanta, GA, USA 2 Center 3 Present address: Brigham Women's Hospital, Boston, MA, Correspondence to: Hadjipanayis, email: Keywords : glioblastoma stem-like cells (GSCs), iron-oxide nanoparticles (IONPs), cetuximab, magnetic resonance imaging (MRI), convection-enhanced...
BACKGROUND: In July 2009, the Accreditation Council for Graduate Medical Education (ACGME) incorporated postgraduate year 1 (PGY1 intern) level training into all U.S. neurosurgery residency programs. OBJECTIVE: To provide a fundamentals curriculum incoming PGY1 residents in ACGME-accredited programs, including skills, knowledge, and attitudes that promote quality, patient safety, professionalism. METHODS: The Society of Neurological Surgeons organized 6 regional "boot camp" courses 2010...
A retrospective review of prospectively collected data.The purpose this study is to compare and validate several preoperative scores for predicting outcomes following spine tumor resection.Preoperative risk assessment patients undergoing spinal resection remains challenging. At present, few tools have been validated in high-risk population.The 2008 2014 National Surgical Quality Improvement database was used identify all surgical tumors, stratified as extradural, intradural extramedullary,...
OBJECTIVE Antiepileptic drugs (AEDs) are often administered prophylactically following brain tumor resection. With conflicting evidence and unestablished guidelines, however, the nature of this practice among surgeons is unknown. METHODS On November 24, 2015, a REDCap (Research Electronic Database Capture) survey was sent to members AANS/CNS Section on Tumors query patterns. RESULTS Responses were received from 144 individuals, including 18.8% board-certified neurosurgeons surveyed (across...
Abstract Background Glioblastoma (GBM) remains a largely incurable disease as current therapy fails to target the invasive nature of glioma growth in progression and recurrence. Here, we use FDA-approved drug small molecule Hippo inhibitor Verteporfin (VP) YAP-TEAD activity, known mediate convergent aspects tumor invasion/metastasis, assess drug’s efficacy survival benefit GBM models. Methods Up 8 low-passage patient-derived cell lines with distinct genomic drivers, including 3...
Long-term outcomes of radiotherapy are important in understanding the risks and benefits therapies for patients with brain metastases.To determine how use postoperative whole-brain (WBRT) or stereotactic radiosurgery (SRS) is associated quality life (QOL), cognitive function, intracranial tumor control long-term survivors 1 to 4 metastases.This secondary analysis a randomized phase 3 clinical trial included 48 institutions US Canada. Adult resected metastases but limited those metastasis...
Treatment options for unresectable new and recurrent glioblastoma remain limited. Laser ablation has demonstrated safety as a surgical approach to treating primary brain tumors. The LAANTERN prospective multicenter registry (NCT02392078) data were analyzed determine clinical outcomes patients with IDH wild-type glioblastoma.Demographics, intraprocedural data, adverse events, KPS, health economics, survival prospectively collected then on newly diagnosed who treated laser at 14 US centers...
The efficacy of stereotactic intracavitary irradiation with phosphorus-32 ((32)P) for patients cystic craniopharyngiomas was assessed on the basis patient survival, tumor control, and visual endocrinological function before after treatment. Limited data are available regarding long-term outcomes.Forty-nine were treated (32)P irradiation. Of these, 25 had no prior treatment as primary treatment, 24 residual or recurrent cysts. At time irradiation, 34 adults, 15 children younger than 16 years...