A5050138944- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Cancer-related cognitive impairment studies
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Spine and Intervertebral Disc Pathology
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Advances in Oncology and Radiotherapy
- Brain Tumor Detection and Classification
- Salivary Gland Tumors Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Education and Professional Development
- Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
Juravinski Cancer Centre
2014-2023
McMaster University
2012-2022
Juravinski Hospital
2019
Hamilton Health Sciences
2013-2019
Novartis (Canada)
2019
Ontario Clinical Oncology Group
2016
The University of Texas Southwestern Medical Center
2015
Neurological Surgery
2015
Dalhousie University
2015
University of Toronto
2015
Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated can be used to avoid conformally the hippocampal compartment WBRT (HA-WBRT). RTOG 0933 was single-arm phase II study of HA-WBRT for brain metastases with prespecified comparison historical control patients treated without avoidance.Eligible adult received 30 Gy 10 fractions. Standardized cognitive function and quality-of-life (QOL) assessments were performed at...
BackgroundSurgery for malignant disease carries a high risk of deep vein thrombosis. The aim this study was to evaluate the prophylactic effect low molecular weight heparin, enoxaparin, 40 mg once daily, beginning 2 h before surgery, compared with that unfractionated low-dose heparin three times daily.
Long-term outcomes of radiotherapy are important in understanding the risks and benefits therapies for patients with brain metastases.To determine how use postoperative whole-brain (WBRT) or stereotactic radiosurgery (SRS) is associated quality life (QOL), cognitive function, intracranial tumor control long-term survivors 1 to 4 metastases.This secondary analysis a randomized phase 3 clinical trial included 48 institutions US Canada. Adult resected metastases but limited those metastasis...
We reviewed the results of arthroscopic staple capsulorrhaphy on 47 patients with a followup 4 years. Thirty-four shoulders had history traumatic dislocation, while remaining 13 subluxation. The recurrence rate was 25%, 8 developing recurrent frank dislocation and Only 21 were able to resume normal sporting activities after surgical repair. no cases loosening within joint, but we did have 3 whose staples removed because persistent pain in shoulder.
Abstract: Local recurrence represents a significant challenge in the management of patients with glioblastoma multiforme. Salvage treatment options are limited by lack clinical efficacy. Recent studies have demonstrated response rate and acceptable toxicity use fractionated stereotactic radiosurgery this patient population. Our primary objective was to determine efficacy combined concurrent temozolomide chemotherapy as salvage for recurrent We prospectively collected outcome data having...
Radiation-induced brain necrosis ["radionecrosis" (rn)] is a relatively uncommon but potentially severe adverse effect of stereotactic radiosurgery (srs) for metastasis. Although dose, volume, and hypofractionation have been suggested to affect rn rates, patient treatment variability in this population make it difficult clearly delineate the risk. We set out establish fractionation on rates by reviewing patients receiving simultaneous multi-fraction single-fraction at our centre.
NRG Oncology's RTOG 0933 demonstrated benefits to memory preservation after hippocampal avoidant whole-brain radiation therapy (HA-WBRT), the avoidance of dose hippocampus (using intensity modulated planning and delivery techniques) during WBRT, supporting hypothesis radiosensitivity associated specificity. However, some patients cognitive decline, suggesting mechanisms outside play a role. White matter injury (WMI) has been implicated in therapy-induced neurocognitive decline. This...
Introduction: Survival after a diagnosis of brain metastasis in non-small-cell lung cancer (nsclc) is generally poor. We previously reported median survival approximately 4 months cohort patients treated with whole-brain radiotherapy (wbrt). Since that time, we implemented program stereotactic radiosurgery (srs). In the present study, examined and prognostic factors consecutive introduction srs program. Methods: Data from retrospective review 167 nsclc referred to tertiary centre during...
Stereotactic radiosurgery (SRS) has replaced whole brain radiotherapy (WBRT) as standard therapy for most patients with four or fewer metastases due to improved cognitive outcomes and more favorable health related quality of life (QoL). Whether SRS WBRT is the optimal radiation modality five fifteen remains an open question. Efforts are underway develop prospective evidence answer this One planned trials a Canadian Cancer Trials Group (CCTG)-lead North American intergroup trial. In general...
Robotic system has been used for stereotactic body radiotherapy (SBRT) of prostate cancer. Arc-based and fixed-gantry systems are hypofractionated regimens (10-20 ractions) the standard regimen (39 fractions); they may also be to deliver SBRT. Studies currently underway compare efficacy safety these regimens. Thus, we describe technique required resources provision robotic SBRT in relation other guide investment decisions. Using administrative data resource volumes unit prices, computed cost...
Abstract Background. Management of glioblastoma is complicated by pseudoprogression, a radiological phenomenon mimicking progression. This retrospective cohort study investigated the incidence, prognostic implications, and most clinically appropriate definition pseudoprogression. Methods. Consecutive patients treated at Juravinski Hospital Cancer Centre, Hamilton, Ontario between 2004 2012 with temozolomide chemoradiotherapy contrast-enhanced MRI standard imaging intervals were included. At...