A5062274391- Neurobiology of Language and Bilingualism
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Meningioma and schwannoma management
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cancer-related cognitive impairment studies
- Neuroscience and Neuropharmacology Research
- Hemispheric Asymmetry in Neuroscience
- Brain Metastases and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Spatial Neglect and Hemispheric Dysfunction
- Anesthesia and Sedative Agents
- Neuroscience and Neural Engineering
- Pharmacological Effects and Toxicity Studies
- Memory and Neural Mechanisms
- Face Recognition and Perception
- Advanced Memory and Neural Computing
- MRI in cancer diagnosis
- Anatomy and Medical Technology
- Vascular Malformations Diagnosis and Treatment
Mayo Clinic in Florida
2019-2025
Neurological Surgery
2020-2025
Jacksonville College
2019-2024
Nemours Children's Health System
2024
Mayo Clinic
2024
WinnMed
2019-2024
Western University
2024
West Virginia University
2023
Duke University
2021
Institute of Psychology
2021
<b><i>Background:</i></b> Left anterior temporal lobectomy (L-ATL) may be complicated by confrontation naming deficits. <b><i>Objective: </i></b> To determine whether preoperative fMRI predicts such deficits in patients with epilepsy undergoing L-ATL. <b><i>Methods:</i></b> Twenty-four L-ATL underwent language mapping fMRI, intracarotid amobarbital (Wada) testing for dominance, and pre- postoperative neuropsychological testing. laterality indexes (LIs), reflecting the interhemispheric...
Summary Purpose: Verbal memory decline is a frequent complication of left anterior temporal lobectomy (L‐ATL). The goal this study was to determine whether preoperative language mapping using functional magnetic resonance imaging (fMRI) useful for predicting which patients are likely experience verbal after L‐ATL. Methods: Sixty L‐ATL underwent with fMRI, intracarotid amobarbital (Wada) testing and lateralization, pre‐ postoperative neuropsychological testing. Demographic, historical,...
Many fMRI protocols for localizing speech comprehension have been described, but there has little quantitative comparison of these methods. We compared five such in terms areas activated, extent activation, and lateralization.
Summary Purpose To more definitively characterize Wada/functional magnetic resonance imaging (f MRI ) language dominance discordance rates with the largest sample of patients epilepsy to date, and examine demographic, clinical, methodologic predictors discordance. Methods Two hundred twenty‐nine underwent both a standardized Wada test semantic decision f protocol in prospective research study. Language laterality indices were computed for each using automated double‐blind methods, Wada/f...
OBJECTIVE The authors’ goal was to use a multicenter, observational cohort study determine whether supramarginal resection (SMR) of FLAIR-hyperintense tumor beyond the contrast-enhanced (CE) area influences overall survival (OS) patients with isocitrate dehydrogenase–wild-type (IDH-wt) glioblastoma after gross-total (GTR). METHODS medical records 888 aged ≥ 18 years who underwent GBM between January 2011 and December 2017 were reviewed. Volumetric measurements CE surrounding performed,...
Language lateralization measured by preoperative functional magnetic resonance imaging (fMRI) was shown recently to be predictive of verbal memory outcome in patients undergoing left anterior temporal lobe (L-ATL) resection. The aim this study determine whether language or the hippocampus is a better predictor setting.Thirty L-ATL underwent fMRI, hippocampal fMRI using scene encoding task, and pre- postoperative neuropsychological testing. A group 37 right ATL (R-ATL) surgery included for...
Recent studies have proposed resection of the T2 FLAIR hyperintensity beyond T1 contrast enhancement (supramarginal [SMR]) for IDH-wild-type glioblastoma (GBM) to further improve patients' overall survival (OS). GBMs significant variability in tumor cell density, distribution, and infiltration. Advanced mathematical models based on patient-specific radiographic features provided new insights into GBM growth kinetics two important parameters aggressiveness: proliferation rate (ρ) diffusion...
Importance Implementing multidisciplinary teams for treatment of complex brain tumors needing awake craniotomies is associated with significant costs. To date, there a paucity analysis on the cost utility introducing advanced standardized to enable craniotomies. Objective assess program Design, Setting, and Participants A retrospective economic evaluation was conducted at Mayo Clinic Florida. All patients single, unilateral lesions who underwent elective between January 2016 December 2021...
Purpose: These American Clinical Neurophysiology Society technical standards suggest best practices for electrical stimulation mapping (ESM) with subdural and stereotactic depth electrodes seizure induction of brain function. Methods: A working group was convened from membership expertise in ESM. PubMed searches were performed to identify pertinent peer-reviewed literature. Recurrent meetings reviewed progress, built consensus by discussion, developed evidence-based recommendations the...
Summary: Purpose: The ideal candidate for anterior temporal lobectomy surgery shows a Wada memory asymmetry (WMA) score characterized by better performance in the hemisphere contralateral to seizure focus relative ipsilateral (surgical) hemisphere. However, some surgical candidates show reversed WMA or of interest focus. To date, no data are available contrasting and outcome these two groups. present study compared after left (L‐ATL) patients showing expected scores, also examined...
NRG Oncology's RTOG 0933 demonstrated benefits to memory preservation after hippocampal avoidant whole-brain radiation therapy (HA-WBRT), the avoidance of dose hippocampus (using intensity modulated planning and delivery techniques) during WBRT, supporting hypothesis radiosensitivity associated specificity. However, some patients cognitive decline, suggesting mechanisms outside play a role. White matter injury (WMI) has been implicated in therapy-induced neurocognitive decline. This...
OBJECTIVE Traditionally, resection of nondominant hemisphere brain tumors was performed under general anesthesia. An improved understanding right-lateralized neural networks has led to a paradigm shift in recent decades, where the right or is no longer perceived as "functionally silent." There an increasing interest awake mapping for resections. The objective this study perform comprehensive review existing paradigms patients with gliomas undergoing craniotomies. METHODS In accordance PRISMA...