William D. Freeman
A5085592232- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- Atrial Fibrillation Management and Outcomes
- Sepsis Diagnosis and Treatment
- Telemedicine and Telehealth Implementation
- Vascular Malformations Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Infectious Encephalopathies and Encephalitis
- Pharmacological Effects and Toxicity Studies
- Cerebral Venous Sinus Thrombosis
- Aortic Disease and Treatment Approaches
- Pituitary Gland Disorders and Treatments
- Hospital Admissions and Outcomes
- Retinal and Optic Conditions
- Thermal Regulation in Medicine
Jacksonville College
2016-2025
Mayo Clinic in Florida
2016-2025
WinnMed
2016-2025
Mayo Clinic in Arizona
2005-2025
Mayo Clinic
2006-2024
Neurological Surgery
2017-2024
Neurology, Inc
2012-2024
University of California, Irvine
2023
Johns Hopkins University
2016-2023
Mayo Clinic Hospital
2010-2023
Many patients with severe stroke have impaired airway protective reflexes, resulting in prolonged invasive mechanical ventilation.To test whether early vs standard tracheostomy improved functional outcome among receiving ventilation.In this randomized clinical trial, 382 acute ischemic or hemorrhagic ventilation were randomly assigned (1:1) to (≤5 days of intubation) ongoing ventilator weaning if needed from day 10. Patients between July 28, 2015, and January 24, 2020, at 26 US German...
The earliest recorded application of therapeutic hypothermia in medicine spans about 5000 years; however, its use has become widespread since 2002, following the demonstration both safety and efficacy regimens requiring only a mild (32°C-35°C) degree cooling after cardiac arrest. We review mechanisms by which confers neuroprotection as well physiological effects body system associated risks. With regard to clinical applications, we present evidence on role traumatic brain injury,...
Abstract BACKGROUND Minimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with recombinant tissue plasminogen activator hold a promise to improve outcome supratentorial brain hemorrhage, morbid disabling type stroke. A recently completed Phase III randomized trial showed improved mortality but was neutral on the primary (modified Rankin scale score 0 3 at 1 yr). OBJECTIVE To assess surgical performance its impact...
Object Near-infrared spectroscopy (NIRS) offers noninvasive bedside measurement of direct regional cerebral arteriovenous (mixed) brain oxygenation. To validate the accuracy this monitoring technique, authors analyzed statistical correlation NIRS and CT perfusion with respect to blood flow (CBF) measurements. Methods The retrospectively reviewed all cases in which measurements were obtained at a single, academic neurointensive care unit from February 2008 June 2011 was performed same time as...
Abstract Background The primary aim of this study was to determine the safety and feasibility capturing streaming neuronavigation images onto a head‐up display during spine instrumentation. Methods Using novel device, were captured transferred wirelessly via password‐encrypted network display. At end procedure, surgeons completed survey gather their opinions system. Results Forty pedicle screws placed using average screw placement time slightly shorter when used (4.13 min with vs. 4.86...
Elevated intracranial pressure and inadequate cerebral perfusion may contribute to poor outcomes in hypertensive intraventricular hemorrhage. We characterized the occurrence of elevated low obstructive hemorrhage requiring extraventricular drainage.
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this to evaluate efficacy safety single intraventricular 600 mg dose hemorrhage, compared standard care oral nimodipine. Methods— Subjects were World Federation Neurological Surgeons grades 2–4, modified Fisher 2–4 had an inserted as...
RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.
Importance Implementing multidisciplinary teams for treatment of complex brain tumors needing awake craniotomies is associated with significant costs. To date, there a paucity analysis on the cost utility introducing advanced standardized to enable craniotomies. Objective assess program Design, Setting, and Participants A retrospective economic evaluation was conducted at Mayo Clinic Florida. All patients single, unilateral lesions who underwent elective between January 2016 December 2021...