Sothear Luke

ORCID: 0000-0003-0090-8601
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About
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Research Areas
  • Cerebrovascular and Carotid Artery Diseases
  • Cancer-related molecular mechanisms research
  • Intracranial Aneurysms: Treatment and Complications
  • Genetic Associations and Epidemiology
  • Vascular Malformations Diagnosis and Treatment
  • Cardiovascular Disease and Adiposity
  • Neurosurgical Procedures and Complications
  • Optical Imaging and Spectroscopy Techniques
  • Cancer-related gene regulation
  • Peripheral Artery Disease Management
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Hemodynamic Monitoring and Therapy
  • Radiation Dose and Imaging
  • Blood Coagulation and Thrombosis Mechanisms
  • Cardiac, Anesthesia and Surgical Outcomes
  • Cardiovascular Health and Disease Prevention

University of Maryland, Baltimore
2022

VA Maryland Health Care System
2022

Mayo Clinic in Florida
2011-2020

WinnMed
2012-2020

Jacksonville College
2012-2017

Society for Neuroscience
2012

Object Near-infrared spectroscopy (NIRS) offers noninvasive bedside measurement of direct regional cerebral arteriovenous (mixed) brain oxygenation. To validate the accuracy this monitoring technique, authors analyzed statistical correlation NIRS and CT perfusion with respect to blood flow (CBF) measurements. Methods The retrospectively reviewed all cases in which measurements were obtained at a single, academic neurointensive care unit from February 2008 June 2011 was performed same time as...

10.3171/2011.12.focus11280 article EN Neurosurgical FOCUS 2012-02-01
Thomas Jaworek Huichun Xu Brady Gaynor John W. Cole Kristiina Rannikmäe and 95 more Tara M. Stanne Liisa Tomppo Vida Abedi Philippe Amouyel Nicole D. Armstrong John Attia Steven Bell Oscar Benavente Giorgio B. Boncoraglio Adam S. Butterworth Jara Cárcel‐Márquez Zhengming Chen Michael Chong Carlos Cruchaga Mary Cushman John Danesh Stéphanie Debette David Duggan Jon Peter Durda Gunnar Engström Chris Enzinger Jessica D. Faul Natalie Fecteau Israel Fernández‐Cadenas Christian Gieger Anne‐Katrin Giese Raji P. Grewal Ulrike Grittner Aki S. Havulinna Laura Heitsch Marc C. Hochberg Elizabeth G. Holliday Jie Hu Andreea Ilinca Marguerite R. Irvin Rebecca D. Jackson Mina A. Jacob Raquel Rabionet Jordi Jiménez-Conde Julie A. Johnson Yoichiro Kamatani Sharon L. R. Kardia Masaru Koido Michiaki Kubo Leslie A. Lange Jin‐Moo Lee Robin Lemmens Christopher Levi Jiang Li Liming Li Kuang Lin Haley Lopez Sothear Luke Jane Maguire Patrick F. McArdle Caitrin W. McDonough James F. Meschia Tiina M. Metso Martina Müller‐Nurasyid Timothy D. O’Connor Martin O’Donnell Leema Reddy Peddareddygari Joanna Pera James A. Perry Annette Peters Jukka Putaala Debashree Ray Kathryn M. Rexrode Marta Ribasés Jonathan Rosand Peter M. Rothwell Tatjana Rundek Kathleen A. Ryan Ralph L. Sacco Veikko Salomaa Cristina Sánchez‐Mora Reinhold Schmidt Pankaj Sharma Agnieszka Słowik Jennifer A. Smith Nicholas L. Smith Sylvia Wassertheil‐Smoller Martin Söderholm O. Colin Stine Daniel Strbian Cathie Sudlow Turgut Tatlisumak Chikashi Terao Vincent Thijs Nuria P. Torres‐Aguila David‐Alexandre Trégouët Anil M. Tuladhar Jan H. Veldink Robin Walters David R. Weir

Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought identify the contribution common genetic variants risk early-onset stroke.

10.1212/wnl.0000000000201006 article EN cc-by Neurology 2022-08-31

IntroductionThe COVID-19 pandemic has presented challenges to managing vascular risk factors with in-person follow-up of patients asymptomatic carotid stenosis enrolled in the CREST2 trial. is comparing intensive medical management alone versus plus revascularization endarterectomy or stenting. We performed a study evaluate feasibility home-based program for testing blood pressure (BP) and low-density lipoprotein (LDL) CREST2.MethodsThis involved 45 at 10 sites The initial were identified by...

10.1016/j.jstrokecerebrovasdis.2020.105362 article EN other-oa Journal of Stroke and Cerebrovascular Diseases 2020-09-30

Introduction: Outcomes from endovascular procedures are highly dependent on the experience and skill of operating physician. The multi-disciplinary CREST-2 Interventional Management Committee (IMC) was charged with credentialing a cohort skilled interventionists adequate contemporary case volumes. Methods: Applicants were required to submit 25 consecutive cases completed within 5 years as primary operator out total ≥ 50 (≥ 20 for operators completing training). Interventionists not approved...

10.1161/str.48.suppl_1.tp119 article EN Stroke 2017-02-01
Thomas Jaworek Huichun Xu Brady Gaynor John W. Cole Kristiina Rannikmäe and 95 more Tara M. Stanne Liisa Tomppo Vida Abedi Philippe Amouyel Nicole D. Armstrong John Attia Steven Bell Oscar Benavente Giorgio B. Boncoraglio Adam S. Butterworth Jara Cárcel‐Márquez Zhengming Chen Michael Chong Carlos Cruchaga Mary Cushman John Danesh Stéphanie Debette David Duggan Jon Peter Durda Gunnar Engström Christian Enzinger Jessica D. Faul Natalie Fecteau Israel Fernández‐Cadenas Christian Geiger Anne‐Katrin Giese Raji P. Grewal Ulrike Grittner Aki S. Havulinna Laura Heitsch Marc C. Hochberg Elizabeth G. Holliday Jie Hu Andreea Ilinca Marguerite R. Irvin Rebecca D. Jackson Mina A. Jacob Raquel Rabionet Jordi Jiménez-Conde Julie A. Johnson Yoichiro Kamatani Sharon L.R. Kardia Masaru Koido Michiaki Kubo Leslie A. Lange Jin‐Moo Lee Robin Lemmens Christopher Levi Jiang Li Liming Li Kuang Lin Haley Lopez Sothear Luke Jane Maguire Patrick F. McArdle Caitrin W. McDonough James F. Meschia Tiina M. Metso Martina Müller‐Nurasyid Timothy D. O’Connor Martin O’Donnell Leema Reddy Peddareddygari Joanna Pera James A. Perry Annette Peters Jukka Putaala Debashree Ray Kathryn M. Rexrode Marta Ribasés Jonathan Rosand Peter M. Rothwell Tatjana Rundek Kathleen A. Ryan Ralph L. Sacco Veikko Salomaa Cristina Sánchez‐Mora Reinhold Schmidt Pankaj Sharma Agnieszka Słowik Jennifer A. Smith Nicholas L. Smith Sylvia Wassertheil‐Smoller Martin Söderholm O. Colin Stine Daniel Strbian Cathie Sudlow Turgut Tatlisumak Chikashi Terao Vincent Thijs Nuria P. Torres‐Aguila David‐Alexandre Trégouët Anil M. Tuladhar Jan H. Veldink Robin Walters David R. Weir

Abstract Objective To determine the contribution of common genetic variants to risk early onset ischemic stroke (IS). Methods We performed a meta-analysis genome-wide association studies IS, ages 18-59, using individual level data or summary statistics in 16,927 cases and 576,353 non-stroke controls from 48 different across North America, Europe, Asia. further compared effect sizes at our most significant loci between late IS polygenic scores for venous thromboembolism versus later IS....

10.1101/2021.11.06.21265795 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2021-11-08
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