A5088743625- Acute Ischemic Stroke Management
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Substance Abuse Treatment and Outcomes
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Alcohol Consumption and Health Effects
- Dementia and Cognitive Impairment Research
- Lysosomal Storage Disorders Research
- Health disparities and outcomes
- Health and Medical Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer survivorship and care
- Homelessness and Social Issues
- Myasthenia Gravis and Thymoma
- Spatial Neglect and Hemispheric Dysfunction
- Childhood Cancer Survivors' Quality of Life
- Diet and metabolism studies
- Palliative Care and End-of-Life Issues
- Cellular transport and secretion
- Atrial Fibrillation Management and Outcomes
- EEG and Brain-Computer Interfaces
Humboldt-Universität zu Berlin
2015-2025
Charité - Universitätsmedizin Berlin
2016-2025
Zimmer Biomet (Germany)
2015-2025
Freie Universität Berlin
2005-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2016-2025
MSB Medical School Berlin
2025
Humboldt State University
2023
Friedrich Schiller University Jena
2023
Jena University Hospital
2023
Max Delbrück Center
2015-2022
Time to thrombolysis is crucial for outcome in acute ischemic stroke.To determine if starting a specialized ambulance reduces delays.In the Prehospital Acute Neurological Treatment and Optimization of Medical care Stroke Study (PHANTOM-S), conducted Berlin, Germany, we randomly assigned weeks with without availability Emergency Mobile (STEMO) from May 1, 2011, January 31, 2013. Berlin has an established stroke infrastructure 14 units. We included 6182 adult patients (STEMO weeks: 44.3% male,...
Aims: We investigated the presence of social inequalities alcohol use and misuse using educational attainment as an indicator socio-economic status in 15 countries: Sweden, Norway, Finland, Germany, The Netherlands, Switzerland, Hungary, Czech Republic, Israel, Brazil, Mexico. Methods: Study surveys were independently conducted data centrally analysed. Most samples national. Survey modes sample sizes varied. age range was restricted to between 25 59 years age. Socio-economic measured by...
The sFlt-1/PlGF ratio has been evaluated as a diagnostic marker for preeclampsia (PE). aim of this study was to explore the use an aid in prediction PE.150 patients with high risk PE were enrolled prospective study. Groups compared according pregnancy outcome: controls (n=114), intrauterine growth restriction (IUGR) (n=14) and (n=22) subclassification early PE<34 weeks (n=6). Measurements sFlt-1 PlGF performed on automated Elecsys system. Statistical comparison different outcome groups mixed...
Numerous treatments have been reported to provide a beneficial outcome in experimental animal stroke models; however, these (with the exception of tissue plasminogen activator) failed clinical trials. To improve translation treatment efficacy from bench bedside, we performed preclinical randomized controlled multicenter trial (pRCT) test potential therapy under circumstances closer design and rigor control trial. Anti-CD49d antibodies, which inhibit migration leukocytes into brain, were...
Background and Purpose— As stroke in young adults is assumed to have different etiologies risk factors than older populations, the aim of this study was examine contribution established potentially modifiable cardiovascular burden adults. Methods— A German nationwide case–control based on patients enrolled SIFAP1 (Stroke In Young Fabry Patients) 2007 2010 controls from population-based GEDA (German Health Update) 2009 performed. Cases were 2125 consecutive aged 18 55 years with acute...
Background and Purpose— Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease young adults. Although risk factors manifestation atherosclerosis are commonly associated with stroke elderly, recent data suggests different causes for young. We initiated prospective, multinational European study Stroke Young Fabry Patients (sifap) to characterize a cohort patients. Methods—...
<h3>Importance</h3> Effects of thrombolysis in acute ischemic stroke are time-dependent. Ambulances that can administer (mobile units [MSUs]) before arriving at the hospital have been shown to reduce time treatment. <h3>Objective</h3> To determine whether dispatch MSUs is associated with better clinical outcomes for patients stroke. <h3>Design, Setting, and Participants</h3> This prospective, nonrandomized, controlled intervention study was conducted Berlin, Germany, from February 1, 2017,...
Aims: To compare drinking habits and to examine differences between cultures in different regions countries Europe; gender them over countries. Methods: Data consisted of independently conducted, centrally analysed surveys the general population aged 20–64 years 14 European Central measures were abstention, frequency volume overall by beverage type, amounts drunk per day, heavy episodic drinking. Results: There clear all measures, except for wine Differences genders often smaller than...
For this cross-sectional study, we aimed to elucidate whether higher glycosylated hemoglobin (HbA1c) and glucose levels exert a negative impact on memory performance hippocampal volume microstructure in cohort of healthy, older, nondiabetic individuals without dementia.In 141 (72 women, mean age 63.1 years ± 6.9 SD), was tested using the Rey Auditory Verbal Learning Test. Peripheral fasting HbA1c, glucose, insulin 3-tesla MRI scans were acquired assess microstructure, as indicated by gray...
Although many stroke patients are young or middle-aged, risk factor profiles in these age groups poorly understood.The Stroke Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of with cerebrovascular events aged 18 to 55 years establish their prevalence disease. In secondary analysis ischemic transient attack, we studied age- and sex-specific prevalences various factors.Among 4467 (median age, 47 years; interquartile range, 40-51), the most...
Background: International comparisons of social inequalities in alcohol use have not been extensively investigated. The purpose this study was to examine the relationship country-level characteristics and individual socio-economic status (SES) on consumption 33 countries. Methods: Data 101 525 men women collected by cross-sectional surveys countries GENACIS were used. Individual SES measured highest attained educational level. Alcohol measures included drinking monthly risky single occasion...
Background Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement enzyme activity, genetic testing as well analysis chitotriosidase and CCL18/PARC biomarkers. Even though well-established biomarker in GD, not specific for GD. Furthermore, may be false negative significant percentage GD patients due mutation. Additionally, reflects...
Fabry disease (FD) is an X-linked hereditary defect of glycosphingolipid storage caused by mutations in the gene encoding lysosomal hydrolase α-galactosidase A (GLA, α-gal A). To date, over 400 causing amino acid substitutions have been described. Most these are related to classical phenotype. Generally disorders a reliable genotype/phenotype correlation difficult achieve, especially FD with its mode inheritance. In order predict metabolic consequence given mutation, we combined vitro enzyme...
Abstract Cigarette smoking is a severe health burden being related to number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated be involved the pathophysiology several disorders and may relevant for nicotine dependence. Therefore, determining frequency disturbance otherwise healthy its association with degree dependence highly relevant. In population‐based case‐control study, 1071 1243 non‐smokers without lifetime D...
As the process of Alzheimer's disease (AD) begins years before onset, searching for prevention strategies is major medical and economic importance. Nutritional supplementation with long-chain polyunsaturated omega-3 fatty acids (LC-n3-FA) may exert beneficial effects on brain structure a nd function. However, experimental evidence in older adults without clinical dementia inconsistent, possibly due to low sensitivity previously employed test batteries detecting subtle improvements cognition...
Transcranial direct current stimulation (tDCS) modulates human behavior, neuronal patterns, and metabolite concentrations, with exciting potential for neurorehabilitation. However, the understanding of tDCS-induced alterations on level is incomplete, conclusions from young adults, in whom majority studies have been conducted, cannot be easily transferred to older populations. Here, we investigated effects adults ( N = 48; age range, 50–79 years) using magnetic resonance spectroscopy quantify...
Purpose To assess whether ultrasonography (US)-based real-time elastography (RTE) can be used to detect gut fibrosis. Materials and Methods In this institutional review board–approved, prospective, proof-of-concept study, unaffected affected segments in 10 patients with Crohn disease (four women, six men; median age, 49 years) were examined pre-, intra-, postoperatively US, including RTE strain. Disease activity was scored by using the Limberg index on basis of (a) bowel wall thickness (b)...