A5075491461- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Face Recognition and Perception
- Venous Thromboembolism Diagnosis and Management
- Robotics and Sensor-Based Localization
- EEG and Brain-Computer Interfaces
- Trauma and Emergency Care Studies
- Electronic Health Records Systems
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
- Indoor and Outdoor Localization Technologies
- Blood groups and transfusion
- Blood Pressure and Hypertension Studies
- Telemedicine and Telehealth Implementation
- Ethics in Clinical Research
- Visual perception and processing mechanisms
- Evolutionary Psychology and Human Behavior
- Image and Object Detection Techniques
- Characterization and Applications of Magnetic Nanoparticles
- Neural dynamics and brain function
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
Charité - Universitätsmedizin Berlin
2016-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018-2025
German Centre for Cardiovascular Research
2021-2025
Freie Universität Berlin
1987-2025
Humboldt-Universität zu Berlin
1997-2025
Medico
2024
Shriners Hospitals for Children - Boston
2019
Massachusetts General Hospital
2019
McMaster University
2018
German Center for Neurodegenerative Diseases
2016-2017
Time to thrombolysis is crucial for outcome in acute ischemic stroke.To determine if starting a specialized ambulance reduces delays.In the Prehospital Acute Neurological Treatment and Optimization of Medical care Stroke Study (PHANTOM-S), conducted Berlin, Germany, we randomly assigned weeks with without availability Emergency Mobile (STEMO) from May 1, 2011, January 31, 2013. Berlin has an established stroke infrastructure 14 units. We included 6182 adult patients (STEMO weeks: 44.3% male,...
<h3>Importance</h3> Effects of thrombolysis in acute ischemic stroke are time-dependent. Ambulances that can administer (mobile units [MSUs]) before arriving at the hospital have been shown to reduce time treatment. <h3>Objective</h3> To determine whether dispatch MSUs is associated with better clinical outcomes for patients stroke. <h3>Design, Setting, and Participants</h3> This prospective, nonrandomized, controlled intervention study was conducted Berlin, Germany, from February 1, 2017,...
<h3>Importance</h3> The effectiveness of intravenous thrombolysis in acute ischemic stroke is time dependent. effects are likely to be highest if the from symptom onset treatment within 60 minutes, termed the<i>golden hour</i>. <h3>Objective</h3> To determine achievable rate golden hour prehospital care and its effect on outcome. <h3>Design, Setting, Participants</h3> prospective controlled Prehospital Acute Neurological Treatment Optimization Medical Care Stroke study was conducted Berlin,...
Beneficial effects of IV tissue plasminogen activator (tPA) in acute ischemic stroke are strongly time-dependent. In the Pre-Hospital Acute Neurological Treatment and Optimization Medical care Stroke (PHANTOM-S) study, we undertook treatment using a specialized ambulance, emergency mobile unit (STEMO), to shorten call-to-treatment time.The ambulance was staffed with neurologist, paramedic, radiographer equipped CT scanner, point-of-care laboratory, teleradiology system. It deployed by...
Specialized management of patients with stroke is not available in all hospitals. We evaluated whether prehospital the Stroke Emergency Mobile (STEMO) improves triage stroke.STEMO an ambulance staffed a specialized team and equipped computed tomographic scanner point-of-care laboratory. compared suspected at dispatcher level who either received STEMO care or conventional care. assessed transport destination different diagnoses. Status hospital discharge was used as short-term outcome.From...
Rationale Time from symptom onset to treatment is closely associated with the effectiveness of intravenous thrombolysis in acute ischemic stroke patients. Hospitals are encouraged take every effort shorten delay treatment. Despite combined efforts streamline procedures hospitals provide as soon possible, most patients receive tissue plasminogen activator considerable and very few them within 90 mins. Germany has an internationally acknowledged prehospital emergency care system specially...
The processing of faces relies on a specialized neural system comprising bilateral cortical structures with dominance the right hemisphere. However, due to inconsistencies earlier findings as well more recent results such functional lateralization has become topic discussion. In particular, studies employing behavioural tasks and electrophysiological methods indicate hemisphere during face perception only in men whereas women exhibit symmetric processing. aim this study was further...
Currently, the relevance of EEG measurements in acute stroke patients is considered low clinical practice. However, recent studies on predictive value after for various outcomes may increase role with stroke. We aimed to review current literature utility as a tool predict outcome and complications, focusing which measurement was performed phase event long-term measures were reported. In our review, we identified 4 different (functional outcome, mortality, development post-stroke cognitive...
Background Mobile stroke units ( MSU s), equipped with an integrated computed tomography scanner, can shorten time to thrombolytic treatment and may improve outcome in patients acute ischemic stroke. Original (German) s are staffed by neurologists trained as emergency physicians, but patient assessment decisions a remote neurologist offer alternative aboard . Methods Results Remote examined assessed treated the Berlin, Germany. Audiovisual quality was rated from 1 (excellent) 6...
Abstract Objective Healthcare data such as clinical notes are primarily recorded in an unstructured manner. If adequately translated into structured data, they can be utilized for health economics and set the groundwork better individualized patient care. To structure notes, deep-learning methods, particularly transformer-based models like Bidirectional Encoder Representations from Transformers (BERT), have recently received much attention. Currently, biomedical applications focused on...
Mobile Stroke Units (MSU) shorten time to intravenous thrombolysis (IVT) and improve functional outcome, but they rely on computed tomography (CT) making them highly specialized costly. Alternative technologies can potentially identify imaging-based IVT contraindications like intracranial hemorrhage (ICH) or malignancies (IM), e.g., by transcranial color-coded sonography (TCCS) near-infrared spectroscopy (NIRS). Using a simulation approach, we analyzed magnetic resonance imaging (MRI) scans...
According to the influential model of Bruce and Young (1986) socially relevant facial information is processed separately from leading individual face recognition. In recent years functional imaging has identified a network distinct occipitotemporal cortex areas for processing these two kinds information. Functionally it not clear at which level "social" "recognition" pathways diverge. The study subjects with profound recognition learning deficit (congenital prosopagnosia—cPA) promises...
Background and Purpose— Copeptin levels are increased in patients diagnosed with stroke other vascular diseases. elevation is associated adverse outcome, predicts re-events transient ischemic attack used ruling-out acute myocardial infarction. We evaluated whether copeptin can also be as a diagnostic marker the prehospital setting. Methods— prospectively examined suspected on Stroke Emergency Mobile—an ambulance that equipped computed tomography point-of-care laboratory. A blood sample was...
Data on effects of intravenous thrombolysis outcome patients with ischemic stroke who are dependent assistance in activities daily living prestroke scarce. Recent registry based analyses -independent suggest that earlier start the prehospital setting leads to better outcomes when compared treatment hospital. We evaluated whether these observations can be corroborated dependency.This observational, retrospective analysis included all acute depending before received either Stroke Emergency...
Congenital prosopagnosia (cPA) is a severe disorder in recognising familiar faces, human characteristic that presumably innate, without any macro-spatial brain anomalies. Following the idea cPA based on deficits of configural face processing, we used speeded grotesqueness decision task with thatcherised since Thatcher illusion can serve as test disruption (Lewis and Johnston, 1997 Perception26 225–227). The time needed to report relation orientation showed dissociate patterns between group...
To determine the effect of additional mobile stroke unit (MSU) dispatch on functional outcomes among full spectrum patients, regardless subtype or potential contraindications to reperfusion therapies.We used data from nonrandomized Berlin-based B_PROUD study (02/2017 05/2019), in which MSUs were dispatched based solely availability, and linked B-SPATIAL registry. All patients with final transient ischemic attack (TIA) diagnoses eligible. The intervention under was an MSU, emergency...
Introduction: In patients with acute intracerebral haemorrhage (ICH) and elevated systolic blood pressure (BP), guidelines suggest that BP reduction to <140 mmHg should be rapidly initiated. Compared conventional care, Mobile Stroke Units (MSUs) allow for earlier ICH diagnosis through prehospital imaging lowering. Patients methods: were prospectively evaluated as a cohort of the controlled B_PROUD-study in which MSU availability alone determined dispatch addition ambulance. We used...
Background and Purpose— Specialized computed tomography–equipped stroke ambulances shorten time to intravenous thrombolysis in acute ischemic by starting treatment before hospital arrival. Because of longer travel-time-to-scene, benefits this concept are expected diminish with distances from base station scene. Methods— We used data the Prehospital Acute Neurological Treatment Optimization Medical Cares Stroke (PHANTOM-S) trial comparing intervals between patients for whom a specialized...