A5057013632- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Autoimmune Neurological Disorders and Treatments
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Neurobiology of Language and Bilingualism
- Neuroscience and Neuropharmacology Research
- Acute Kidney Injury Research
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Mechanical Circulatory Support Devices
- Lanthanide and Transition Metal Complexes
- Glioma Diagnosis and Treatment
Charité - Universitätsmedizin Berlin
2013-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018-2025
Humboldt-Universität zu Berlin
2021-2025
Freie Universität Berlin
1989-2025
Jüdisches Krankenhaus Berlin
2019
German Center for Neurodegenerative Diseases
2018
Heidelberg University
2015
University Hospital Heidelberg
2015
VIB-KU Leuven Center for Microbiology
2015
Hospices Civils de Lyon
2015
Despite the development of new non-ionic lowosmolality contrast media, nephrotoxicity intravascular radio-opaque media remains a severe clinical problem, particularly in patients with risk factors. Widely accepted mechanisms contrast-media-induced are disturbances renal microcirculation due to prolonged intrarenal vasoconstriction, and direct damaging effects on glomerular tubular cells. Calcium channel blocking agents have been shown experimentally clinically ameliorate ischaemic toxic...
Background and Purpose— The so-called smoking-thrombolysis paradox of an improved outcome after thrombolysis was first described in smokers with myocardial infarction. We investigated whether reperfusion rates clinical differ between nonsmokers ischemic stroke intravenous tissue plasminogen activator. Methods— Consecutive acute patients, who had magnetic resonance imaging before 1 day thrombolysis, were included for analysis. All the patients received activator within 4.5 hours. Reperfusion...
Background Accurate prediction of clinical outcomes in individual patients following acute stroke is vital for healthcare providers to optimize treatment strategies and plan further patient care. Here, we use advanced machine learning (ML) techniques systematically compare the functional recovery, cognitive function, depression, mortality first-ever ischemic identify leading prognostic factors. Methods We predicted 307 (151 females, 156 males; 68 ± 14 years) from PROSpective Cohort with...
Background and Purpose— Hyperintense vessels (HVs) have been observed in fluid-attenuated inversion recovery imaging of patients with acute ischemic stroke linked to slow flow collateral arterial circulation. Given the potential importance HV, we used a large, multicenter data set clarify which clinical factors play role HV. Methods— We analyzed 516 from previously published PRE-FLAIR study ( PRE dictive value FLAIR DWI for identification ≤3 ≤4.5 hours symptom onset—a study) study. Patients...
Background and Purpose— We investigated if hyperintensities on fluid-attenuated inversion recovery (FLAIR) sequences in arteries parenchyma are associated with poor outcome 3 months after thrombolysis. Methods— Consecutive acute stroke patients known time of symptom onset who had an MRI before 1 day thrombolysis were included this study. Blinded to follow-up imaging outcome, 2 raters independently judged the presence or absence arterial parenchymal FLAIR hyperintensities. Functional...
<h3>BACKGROUND AND PURPOSE:</h3> Hyperintense vessels on baseline FLAIR MR imaging of patients with ischemic stroke have been linked to leptomeningeal collateralization, yet the ability these maintain viable tissue remains unclear. We investigated whether hyperintense are associated severity hypoperfusion and response thrombolysis in treated intravenous tissue-plasminogen activator. <h3>MATERIALS METHODS:</h3> Consecutive an before within 24 hours treatment, proved vessel occlusion available...
Fluid-attenuated inversion recovery hyperintense vessels (FHV) are frequently observed on magnetic resonance imaging in acute stroke patients with proximal vessel occlusion. Whether FHV can serve as a surrogate for the collateral status and predict functional outcome of is still matter debate.Acute ischemic M1-middle cerebral artery occlusion who received before endovascular treatment 3 hospitals Germany between January 2007 June 2016 were eligible. Quantification was performed using an...
Abstract Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates remain incompletely understood. Using lesion symptom mapping, we demonstrate in the left ventrolateral ventral anterior nucleus are most strongly associated with general impaired semantic phonemic fluency complex comprehension particular. Lesion mapping (using...
Background: Cerebral small vessel disease (CSVD) is a common incidental finding on cerebral MRI in patients with transient ischemic attack (TIA) and stroke has been linked to increased cerebrovascular risk cognitive decline. This study aimed investigate the prevalence of CSVD imaging biomarkers TIA evaluate their association function over three years following event. Methods: A cohort 246 from INSPiRE-TMS (ClinicalTrials.gov: NCT01586702 ) were included. The CSVD-score ? including white...
Abstract Background Ischemic stroke can lead to neuropsychiatric sequelae such as depression and post-traumatic stress disorder (PTSD), resulting in poorer functional outcomes. The POST-stroke PSYchological DIStress PostPsyDis; NCT01187342) study aimed investigate whether ischemic lesions the striatum increase risk of PTSD after stroke. Methods This monocenter, observational, case-control included 84 patients with striatal ( n = 54) non-striatal brain 30). Primary endpoints symptoms...
Background: Currently, stroke patients with unknown time of symptom onset (UTOS) are excluded from therapy intravenous tissue Plasminogen Activator. We hypothesized that MRI‐based thrombolysis is safe in UTOS. Methods: analyzed radiological and clinical data as well outcomes (including UTOS) who received thrombolytic after MRI. Results: Compared to known ( n = 131), UTOS 17) were older (81, 71–88 vs. 75 years, 66–82, P 0.03), had a longer median between last‐seen‐well (12.3 h, IQR 11.5–15.2...
Background and purpose Absence of FLAIR hyperintensity within an acute infarct is associated with stroke onset <4.5 h. However, some patients rapidly develop this timeframe. We hypothesized that development early would predict hemorrhagic transformation ( HT ) in treated tissue plasminogen activator (tPA) < 4.5 h after onset. Methods Consecutive intravenous tPA who had MRI before 1 day thrombolysis were included. Two raters (blind to independently identified reference the...
Background: Post-stroke depression (PSD) affects up to one-third of stroke survivors, significantly impacting rehabilitation success and quality life. However, its underlying pathophysiology remains unclear. Methods: We analyzed two independent, prospective ischemic cohorts (PROSCIS-B NCT01363856 BAPTISe NCT01954797 ; total N=377) identify brain regions networks associated with depressive symptoms post-stroke. Lesion-symptom mapping (LSM) assessed associations between lesion location...
Background and Purpose: In the setting of acute ischemic stroke, increased blood-brain barrier permeability (BBBP) as a sign injury is believed to be associated with risk poor outcome. Pre-clinical studies show that selected serum biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNFα), matrix metallopeptidases (MMP), vascular endothelial growth factors (VEGFs) may play role in BBBP post-stroke. subacute phase also caused by regenerative...
Background and Purpose: A recent study proposed that thrombus perviousness (TP)—the degree to which contrast agents penetrate the in an occluded vessel measured on noncontrast computed tomography (NCCT) CT angiography—may be associated with cardioembolic stroke cause high specificity. Our aim was investigate clinical laboratory parameters affect measures of TP validate its diagnostic accuracy independent cohort patients acute ischemic stroke. Methods: Seventy-five from a prospectively...
A significant amount of strokes are reported to be diffusion-weighted imaging (DWI) negative in acute imaging. We attempted quantify the rate false-negative high-resolution (hr) DWI and identify a valid screening tool guide follow-up MRI diagnose infarction initially not visible on hrDWI.An priori-defined post hoc analysis prospective 3T cohort cerebrovascular events imaged within 24 hours ictus. Basic demographics, risk factors, National Institute Health Stroke Scale, parameters were...
Background: The "smoking paradox" indicates that patients with acute ischemic stroke (AIS) who smoke at the time of their may have a better prognosis after intravenous thrombolysis than non-smokers. However, findings are inconsistent and data analyzing effect smoking on treatment efficacy scarce. Methods: We performed pre-specified post-hoc subgroup analysis Efficacy Safety MRI-Based Thrombolysis in Wake-Up Stroke (WAKE-UP) trial randomized AIS unknown symptom onset had diffusion-weighted...
MRI-based vessel size imaging (VSI) allows for in-vivo assessment of cerebral microvasculature and perfusion. This exploratory analysis (VS) density (Q; both assessed via VSI) in the subacute phase ischemic stroke involved sixty-two patients from BAPTISe cohort (‘Biomarkers And Perfusion--Training-Induced changes after Stroke’) nested within a randomized controlled trial (intervention: 4-week training vs. relaxation). Relative VS, Q, blood volume (rCBV) –flow (rCBF) were calculated for:...
Abstract Patients suffering from strokes are at increased risk of developing post-stroke dementia. Serum anti-NMDA receptor autoantibodies (NMDAR1-abs) have been associated with unfavorable outcomes. However, their effect on specific cognitive domains remains unclear. We used data the prospective multicenter DZNE—mechanisms after stroke (DEMDAS) cohort, and measured NMDAR1-abs in serum baseline. Cognitive function was assessed a comprehensive neuropsychological test battery 6- 12-months...
Anti-NMDA-receptor GluN1 antibodies (NMDAR1-abs) are present in an autoimmune encephalitis with severe neuropsychiatric symptoms. We aimed to estimate the impact of serum NMDAR1-abs on depressive symptoms years after first-ever ischemic stroke (IS). Data were used from PROSpective Cohort Incident Stroke-Berlin (PROSCIS-B; NCT01363856). Serum (IgM/IgA/IgG) measured within 7 days IS using cell-based assays. defined seropositivity as titers ≥1:10, thereof low ≤1:100 and high >1:100. Center for...
Background and Aims: Fluid-attenuated inversion recovery (FLAIR) hyperintense vessels (FHVs) on MRI are a radiological marker of vessel occlusion indirect sign collateral circulation. However, the clinical relevance is uncertain. We explored whether extent FHVs associated with outcome how modify treatment effect thrombolysis in subgroup patients confirmed unilateral from randomized controlled WAKE-UP trial. Methods: One hundred sixty-five were analyzed. Two blinded raters independently...
Abstract Background White matter hyperintensities (WMH) are the result of cerebral small vessel disease and may increase risk cognitive impairment (CI), recurrent stroke, depression. We aimed to explore association between selected cerebrovascular factors (CVRF) WMH load as well effect increased burden on vascular events, CI, depression in first-ever ischemic stroke patients. Methods 431 from PROSpective Cohort with Incident Stroke (PROSCIS) were included; Age-Related Matter Changes (ARWMC)...