A5022358409- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Hemoglobinopathies and Related Disorders
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Iron Metabolism and Disorders
- Meta-analysis and systematic reviews
- Oropharyngeal Anatomy and Pathologies
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone and Joint Diseases
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Blood groups and transfusion
- Indoor Air Quality and Microbial Exposure
- Nutritional Studies and Diet
- Cardiac Health and Mental Health
- Smoking Behavior and Cessation
- Prenatal Screening and Diagnostics
- Stroke Rehabilitation and Recovery
- Winter Sports Injuries and Performance
Medical University of South Carolina
2015-2024
University of Alabama at Birmingham
2008-2022
Mayo Clinic in Florida
2011-2022
University of Alabama
2006-2022
Mayo Clinic
2017-2020
University of Maryland, College Park
2020
Mayo Clinic in Arizona
2014-2020
Munzur University
2020
Heifer International
2012-2020
University of Charleston
2015-2019
Carotid-artery stenting and carotid endarterectomy are both options for treating carotid-artery stenosis, an important cause of stroke.
In the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between stenting group and endarterectomy with respect to primary composite end point of stroke, myocardial infarction, or death during periprocedural period any subsequent ipsilateral stroke 4 years follow-up. We now extend results 10 years.Among patients carotid-artery stenosis who had been randomly assigned endarterectomy, evaluated outcomes every 6 months for up at 117 centers....
BackgroundIn the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST), composite primary endpoint of stroke, myocardial infarction, or death during periprocedural period ipsilateral stroke thereafter did not differ between carotid artery stenting and endarterectomy for symptomatic asymptomatic stenosis. A secondary aim this randomised trial was to compare restenosis occlusion.MethodsPatients with stenosis who were had a transient ischaemic attack, amaurosis fugax, minor...
Background and Purpose— High stroke event rates among carotid artery stenting (CAS)-treated patients in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) lead-in registry generated an a priori hypothesis that age may modify relative efficacy of CAS versus endarterectomy (CEA). In primary CREST report, we previously noted significant effect modification by age. Here extend this investigation examining components end point, treatment-specific impact age, contributors...
Rationale Trials conducted decades ago demonstrated that carotid endarterectomy by skilled surgeons reduced stroke risk in asymptomatic patients. Developments stenting and improvements medical prevention of caused atherothrombotic disease challenge understanding the benefits revascularization. Aim Carotid Revascularization Medical Management for Asymptomatic Stenosis Trial (CREST-2) will test whether or plus contemporary intensive therapy is superior to alone primary patients with high-grade...
The Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) found a higher risk of stroke after carotid artery stenting and myocardial infarction (MI) endarterectomy.Cardiac biomarkers ECGs were performed before 6 to 8 hours either procedure if there was clinical evidence ischemia. In CREST, MI defined as biomarker elevation plus chest pain or ECG An additional category with neither nor abnormality prespecified (biomarker+ only). Crude mortality risk-adjusted for biomarker+...
Background— Stroke occurs more commonly after carotid artery stenting than endarterectomy. Details regarding stroke type, severity, and characteristics have not been reported previously. We describe the strokes that occurred in Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Methods Results— CREST is a randomized, open-allocation, controlled trial with blinded end-point adjudication. was component of primary composite outcome. Patients who received their assigned...
Background and Purpose: Studies of carotid artery disease have suggested that high-grade stenosis can affect cognition, even without stroke. The presence degree cognitive impairment in such patients not been reported compared with a demographically matched population-based cohort. Methods: We studied cognition 1000 consecutive CREST-2 (Carotid Revascularization Medical Management for Asymptomatic Carotid Stenosis Trial) patients, treatment trial asymptomatic disease. Cognitive assessment was...
Objective: The prevalence of helmet use by alpine skiers and snowboarders was estimated self-reports on risk taking were assessed to test for potential compensation when using helmets in these sports. Setting: Skiers observed interviewed at 34 resorts the western United States Canada. Subjects: Respondents 1779 adult 2003 ski season. Outcome measures: Observations questions about perceived speed degree challenge not wearing a (helmet wearers) or previous seasons (non-helmet wearers)....
Diabetes and hypertension impart approximately the same increased relative risk for stroke, although has a larger population-attributable because of its higher population prevalence. With growing epidemic obesity associated increasing prevalence diabetes that disproportionately impacts southeastern Stroke Belt states, any potential contribution to geographic disparity in stroke mortality will only increase.
Background and Purpose— There is debate regarding the approach for analysis of modified Rankin scale scores, most common functional outcome used in acute stroke trials. Methods— We propose to use tests assess treatment differences addressing metric, “if a patient chosen at random from each group if they have different outcomes, what chance who received investigational will better than receiving standard treatment?” This has an associated statement efficacy easily understood by patients...
The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) demonstrated similar rates of the primary composite end point between carotid artery stenting (CAS) and endarterectomy (CEA), although risk stroke was higher with CAS, myocardial infarction CEA. Given large number patients who are candidates for these procedures, an understanding their relative cost cost-effectiveness may have important implications health care policy treatment guidelines.We performed a formal...
The purpose is to determine whether patching during carotid endarterectomy (CEA) affects the perioperative and long-term risks of restenosis, stroke, death, myocardial infarction as compared with primary closure.We identified all patients who were randomized underwent CEA in Carotid Revascularization Endarterectomy versus Stenting Trial. received a patch closure without patch. We periprocedural 4-year event rates, 2-year restenosis rates reoperation between 2 groups. further analyzed results...