Gert J. de Borst
A5020097116- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Aortic aneurysm repair treatments
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Diagnosis and Treatment of Venous Diseases
- Oropharyngeal Anatomy and Pathologies
- Metabolomics and Mass Spectrometry Studies
- Central Venous Catheters and Hemodialysis
- Genetic Associations and Epidemiology
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Moyamoya disease diagnosis and treatment
- Aortic Disease and Treatment Approaches
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
University Medical Center Utrecht
2016-2025
Reinier de Graaf Hospital
2025
Utrecht University
2015-2024
Heidelberg University
2010-2024
University Hospital Heidelberg
2010-2024
Radboud University Nijmegen
2016-2024
Radboud University Medical Center
2016-2024
Surgical Specialties (United States)
2020-2023
Haga Hospital
2020-2022
Beth Israel Deaconess Medical Center
2018-2022
Stenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy uncertain. We report data from the randomised International Carotid Study comparison these treatments.Patients with symptomatic stenosis were randomly assigned 1:1 open stenting or at 50 centres worldwide. Randomisation was computer generated centrally and allocated by telephone call fax. Major outcomes assessed independent endpoint committee unaware assignment. The primary fatal...
anterior accessory saphenous vein ankle brachial index adjustable compression garments ambulatory phlebectomy Ambulatory Selective Varicose Ablation under Local anaesthesia Aberdeen Vein Questionnaire arteriovenous fistula body mass cyanoacrylate adhesive closure Clinical Etiological Anatomical Pathophysiological (classification) catheter directed foam sclerotherapy common femoral conservative haemodynamic treatment of venous incompetence in outpatients (= French acronym for ‘Cure...
Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within cells of human plaques has not been fully assessed. Using single-cell transcriptomics and chromatin accessibility, we gained a better understanding pathophysiology underlying atherosclerosis. We performed RNA ATAC sequencing on carotid atherosclerotic to define at play determine transcriptomic epigenomic characteristics. identified 14 distinct cell populations including endothelial cells,...
Atherosclerotic stenosis of the internal carotid artery is an important cause stroke. The aim this guideline to analyse evidence pertaining medical, surgical and endovascular treatment patients with stenosis. These guidelines were developed based on ESO standard operating procedure followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. working group identified relevant questions, performed systematic reviews meta-analyses literature, assessed quality...
Abstract Background Type 2 diabetes is a condition associated with state of low-grade inflammation caused by adipose tissue dysfunction and insulin resistance. High sensitive-CRP (hs-CRP) marker for systemic higher plasma levels have been cardiovascular events in various populations. The aim the current study to evaluate relation between hs-CRP incident all-cause mortality high-risk type patients. Methods Prospective cohort 1679 patients included Second Manifestations ARTerial disease...
Abstract Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear samples to assess the extent of TCR clonality antigen-specific activation within various subsets. We observed highest degree plaque-specific clonal expansion in effector CD4 + cells, these...