A5010140902- Diabetes Management and Education
- Chronic Disease Management Strategies
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Clinical practice guidelines implementation
- Health Promotion and Cardiovascular Prevention
- Obesity and Health Practices
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Dementia and Cognitive Impairment Research
- Primary Care and Health Outcomes
- Pharmacology and Obesity Treatment
- Cardiac Health and Mental Health
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Parkinson's Disease Mechanisms and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Mobile Health and mHealth Applications
- Neurological and metabolic disorders
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Electronic Health Records Systems
University Medical Center Utrecht
2014-2023
Utrecht University
2012-2023
Huisarts en Wetenschap
2007-2022
OLVG
2020
Leidsche Rijn Julius Health Centers
2009-2018
Danish Diabetes Academy
2018
Heidelberg University
2007-2018
University Hospital Heidelberg
2007-2018
Jeroen Bosch Ziekenhuis
2016
Oklahoma State University Center for Health Sciences
2008-2016
Clinical data on the association of diabetes mellitus with common infections are virtually lacking, not conclusive, and often biased. We intended to determine relative risks in patients type 1 2 (DM1 DM2, respectively).In a 12-month prospective cohort study conducted as part Second Dutch National Survey General Practice, we compared 705 adult who had DM1 6712 DM2 18,911 control hypertension without diabetes. Outcome measures were medically attended episodes infection respiratory tract,...
It is not known whether drugs that block the renin-angiotensin system reduce risk of diabetes and cardiovascular events in patients with impaired glucose tolerance.In this double-blind, randomized clinical trial a 2-by-2 factorial design, we assigned 9306 tolerance established disease or factors to receive valsartan (up 160 mg daily) placebo (and nateglinide placebo) addition lifestyle modification. We then followed for median 5.0 years development (6.5 vital status). studied effects on...
OBJECTIVE— To estimate the health-related quality of life (HRQOL) and treatment satisfaction for patients with type 2 diabetes in Netherlands to examine which patient characteristics are associated satisfaction. RESEARCH DESIGN AND METHODS—For a sample 1,348 patients, recruited by 29 general practitioners, we collected data regarding HRQOL. This study was performed as part larger European (Cost Diabetes Europe - Type [CODE-2]). We used generic instrument (Euroqol 5D) measure Treatment...
The aim of this study was to assess the prevalence (unknown) heart failure and left ventricular dysfunction in older patients with type 2 diabetes.In total, 605 aged 60 years or over diabetes south west Netherlands participated cross-sectional (response rate 48.7%), including 24 a cardiologist-confirmed diagnosis failure. Between February 2009 March 2010, without known underwent standardised diagnostic work-up, medical history, physical examination, ECG echocardiography. An expert panel used...
To estimate the benefits of screening and early treatment type 2 diabetes compared with no late using a simulation model data from ADDITION-Europe study.We used Michigan Model, validated computer model, study to absolute risk cardiovascular outcomes relative reduction associated intensive treatment, routine 3- or 6-year delay in diagnosis factors.When was programmed baseline demographic clinical characteristics population, it accurately predicted empiric results trial. The simulated were...
We sought to determine levels of adherence in eight European countries recommendations for the management type 2 diabetes and investigate factors associated with key intermediate outcomes.GUIDANCE was a cross-sectional study including retrospective data extraction from medical records people recruited, using shared protocol, primary specialist care sites following countries: Belgium, France, Germany, Italy, Ireland, Sweden, Netherlands, United Kingdom. The dataset analysis comprised 7,597...
Abstract Background Type 2 diabetes is a condition associated with state of low-grade inflammation caused by adipose tissue dysfunction and insulin resistance. High sensitive-CRP (hs-CRP) marker for systemic higher plasma levels have been cardiovascular events in various populations. The aim the current study to evaluate relation between hs-CRP incident all-cause mortality high-risk type patients. Methods Prospective cohort 1679 patients included Second Manifestations ARTerial disease...
Abstract Background Progressive β‐cell failure is a characteristic feature of type 2 diabetes; consequently, secretagogues are useful for achieving sufficient glycaemic control. The European GUIDE study the first large‐scale head‐to‐head comparison two sulphonylureas designed once‐daily administration used under conditions everyday clinical practice. Design Eight hundred and forty‐five diabetic patients were randomized to either gliclazide modified release (MR) 30–120 mg daily or glimepiride...
The determinants of cerebral complications type 2 diabetes are unclear. present study aimed to identify metabolic and vascular factors that associated with impaired cognitive performance abnormalities on brain MRI in patients diabetes.
Type 2 diabetes is known to be associated with decrements in memory and executive functions information-processing speed. It less clear, however, at which stage of these cognitive develop how they progress over time. In this study, we investigated functioning patients recent screen-detected type diabetes, thus providing insight into the nature severity early disease. Possible risk factors were also addressed.Included study 183 diabetic from a previously established cohort 69 control...
Type 2 diabetes mellitus (T2DM) brings about an increasing psychosocial problem in adult patients. Prevalence data on and associated factors of related distress (DRD) depression have been lacking Asia. This study aimed to examine the prevalence DRD depression, their Asian T2DM was conducted three public health clinics measuring (Diabetes Distress Scale, DDS), (Patient Health Questionnaire, PHQ). Patients who were at least 30 years age, had for more than one year, with regular follow-up...
Background: The use of a Web portal for patients with diabetes mellitus to access their own personal health record may result in improved outcomes. However, the adoption by is slow. This be caused patient characteristics, but also content, layout, and promotion portal. Detailed knowledge about this could help increase patients' participation portals. Objective: aim was study opinions identify perceived barriers using optimize its use. Methods: We conducted survey among type 1 2 from 62...
OBJECTIVE Methylglyoxal (MGO) is a reactive dicarbonyl compound and potential key player in diabetic cardiovascular disease (CVD). Whether plasma MGO levels are associated with CVD type 2 diabetes unknown. RESEARCH DESIGN AND METHODS We included 1,003 individuals (mean ± SD age 59.1 10.5 years, 69.3% male, 61.6% prior CVD) from the Second Manifestations of ARTerial cohort (SMART). measured two other dicarbonyls (glyoxal [GO] 3-deoxyglucosone [3-DG]) at baseline mass spectrometry. Median...
Treatment guidelines recommend the UK Prospective Diabetes Study (UKPDS) risk engine for predicting cardiovascular in patients with type 2 diabetes, although validation studies showed moderate performance. The methods used these were diverse, however, and sometimes insufficient. Hence, we assessed discrimination calibration of UKPDS to predict 4, 5, 6 8 year diabetes.The cohort included 1,622 diabetes. During a mean follow-up years, followed incidence CHD disease (CVD). Discrimination risk....