A5084771861- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Geriatric Care and Nursing Homes
- Diabetes and associated disorders
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Natural Antidiabetic Agents Studies
- Cardiovascular Function and Risk Factors
- Pain Management and Treatment
- Cardiovascular Disease and Adiposity
- Palliative Care and End-of-Life Issues
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Indigenous Health, Education, and Rights
- Health disparities and outcomes
- Lung Cancer Treatments and Mutations
- Diet, Metabolism, and Disease
University Medical Center Utrecht
2024
UNSW Sydney
2023
GWT-TUD (Germany)
2006-2016
Technische Universität Dresden
1999-2016
Dementia Australia
2005-2012
Center for Clinical Studies
2007
Hôtel-Dieu de Montréal
2004
Humboldt-Universität zu Berlin
2000-2003
Charité - Universitätsmedizin Berlin
1997-2001
Royal Surrey County Hospital
2001
It is not known whether drugs that block the renin-angiotensin system reduce risk of diabetes and cardiovascular events in patients with impaired glucose tolerance.In this double-blind, randomized clinical trial a 2-by-2 factorial design, we assigned 9306 tolerance established disease or factors to receive valsartan (up 160 mg daily) placebo (and nateglinide placebo) addition lifestyle modification. We then followed for median 5.0 years development (6.5 vital status). studied effects on...
The ability of short-acting insulin secretagogues to reduce the risk diabetes or cardiovascular events in people with impaired glucose tolerance is unknown.In a double-blind, randomized clinical trial, we assigned 9306 participants and either disease factors receive nateglinide (up 60 mg three times daily) placebo, 2-by-2 factorial design valsartan addition participation lifestyle modification program. We followed for median 5.0 years incident (and 6.5 vital status). evaluated effect on...
Background and Purpose— Impaired glucose tolerance (IGT)–a prediabetic state–is an important risk factor for atherosclerosis. Acarbose, α-glucosidase inhibitor, was shown in the placebo-controlled prospective study to prevent noninsulin-dependent diabetes mellitus (STOP-NIDDM) trial reduce of by 36% IGT subjects. This article reports on a subgroup analysis STOP-NIDDM examine efficacy acarbose slow progression intima-media thickness (IMT) subjects with IGT. Methods— One hundred thirty-two...
Isolated impaired fasting glucose (IFG) and tolerance (IGT) are two risk categories for type 2 diabetes. This study compared both with respect to the degree of insulin secretion abnormalities resistance.This is a crossover comparison population at high The subjects were recruited from Risk Factor in Impaired Glucose Tolerance Atherosclerosis Diabetes (RIAD) study. They underwent 75-g oral test, measurement specific insulin, C-peptide, proinsulin, free fatty acids baseline every 30 min after...
Background —Immunoadsorption (IA) and subsequent immunoglobulin (Ig) G substitution represent an additional therapeutic approach in dilated cardiomyopathy (DCM). It remains to be elucidated whether this treatment modulates myocardial inflammation, which is possibly a causal factor of ventricular dysfunction. Methods Results —From 25 DCM patients (EF <30%), 12 were randomized for IA therapy IgG at 1-month intervals until month 3. Before (<7 days) after therapy, right biopsies obtained...
To examine the degree to which use of β blockers, statins, and diuretics in patients with impaired glucose tolerance other cardiovascular risk factors is associated new onset diabetes.Reanalysis data from Nateglinide Valsartan Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial.NAVIGATOR trial.Patients who at baseline (enrolment) were treatment naïve blockers (n=5640), (n=6346), statins (n=6146), calcium channel (n=6294). Use blocker was used as a metabolically neutral...
OBJECTIVE: To examine carotid intimal-medial thickness (IMT) and its determinants in newly detected type 2 diabetic subjects, classified according to the new criteria of American Diabetes Association, comparison with age- sex-matched control subjects normal glucose tolerance. RESEARCH DESIGN AND METHODS: This study was case-controlled, matched pairs for 71 diagnosed individuals. Subjects aged 40-70 years were recruited from a risk population diabetes seen Risk Factors IGT Atherosclerosis...
In recent time, it has become more and probable that patients with severe diffuse coronary artery disease, who are not candidates for aortocoronary bypass surgery or percutaneous transluminal angioplasty procedures, can benefit from transmyocardial laser revascularization (TMR). But the underlying principle of TMR still remains unclear. This study reports on a histological analysis eight patients, in whom total 250 channels had been created, died after TMR. The were created by CO2 surrounded...
Background There is no consensus regarding the optimal approach to assessment of quality life people with dementia. We undertook present study describe and determine factors associated ratings a cohort dementia living in residential care facility. Methodology/Principal Findings 351 facilities, their staff family informants participated this cross sectional observational study. Quality was measured using self (Quality Life Alzheimer's Disease [QoL-AD] scale), informant (QoL-AD Related QoL...
Only scarce information exists on the distribution and atherosclerosis risk in different types of hyperglycaemia at diabetes detection. This study aimed to analyse occurrence isolated fasting (IFH), post-challenge (IPH) combined (FH/PH) among subjects detected have association these with cardiovascular factors carotid intima-media thickness (IMT).A total 785 middle-aged Risk Factors Impaired Glucose Tolerance (IGT) for Atherosclerosis Diabetes (RIAD) underwent a 75-g oral glucose tolerance...
Abstract Background DNA methylation in the SHOX2 locus was previously used to reliably detect lung cancer a group of critical controls, including 'cytologically negative' samples with no visible tumor cell content, at high specificity based on analysis bronchial lavage samples. This study aimed investigate, if correlates gene expression and/or copy number alterations. An amplification together observed tumor-specific hypermethylation might explain good performance this marker Methods...
Dementia is five-fold more prevalent among Aboriginal than non-Aboriginal Australians. Despite this, the quality of care available to people living with dementia in remote communities poor. The objective this study was determine ways overcome factors affecting successful delivery services communities, and their families communities.This qualitative research took place Kimberley Region Western Australia. Data collection occurred three stages: (1) interviews service providers identify...
To determine a new category of dysfunctional glucose homeostasis - impaired fasting (IFG) introduced by the American Diabetes Association (ADA) and World Health Organization (WHO) defining those with abnormal but nondiabetic values possible risk for developing diabetes. It is not known whether IFG factor atherosclerosis, as tolerance (IGT).In this case-control cross-sectional study in which oral (75-g OGTT) carotid intima-media thickness (IMT) B mode ultrasound, marker were measured,...
Background. Previous findings of studies on the impact physical illness caregiver health have been inconsistent. The authors wanted to determine whether disability, as determined by SF-12 survey that provides information both and mental problems, contributes stress.
We investigated whether basal insulin as first-line treatment in recently diagnosed type 2 diabetes (T2D) can improve glucose control, microvascular function and preserve secretion comparison with metformin (MET). In this open-label, randomized, prospective 36-week study, 75 patients (44 m, 31 f, mean age 60.7 ± 9.2 year) were allocated to either MET 1,000 mg b.i.d. (n = 36) or glargine (GLA) at bedtime 39). At baseline study end, we performed a continuous monitoring for assessment of...
Background The Dementia In Residential care: EduCation intervention Trial (DIRECT) was conducted to determine if delivery of education designed meet the perceived need GPs and care staff improves quality life participants with dementia living in residential care. Methodology/Principal Findings This cluster-randomised controlled trial 39 aged facilities metropolitan area Perth, Western Australia. 351 facility residents 65 years older Mini-Mental State Examination ≤24, their participated....
We investigated the effect of atorvastatin monotherapy and combined treatment with pioglitazone on intima-media thickness, vascular function cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4±6.5 years; body mass index [BMI] 29.2±4.1 kg/m 2 ; mean±SD) increased (CV) factors were randomised. Intima-media thickness (IMT), augmentation (Aix@75), microvascular response to acetylcholine (LDF), lipid status, plasma levels intact proinsulin, adiponectin, interleukin-6...
Introduction: The literature on the health of and services for older Aboriginal Torres Strait Islander populations is relatively sparse. This study explored development implementation a locally designed community service model care people, people with disability and/or mental problems in remote Australia.Methods: Based extensive consultation families, carers, members stakeholders, was developed to address unmet needs target population their carers Looma, Kimberley region Australia....
<i>Introduction:</i> Recently, patients with refractory sprue have been shown to contain a clonal proliferation of phenotypically abnormal intraepithelial lymphocytes in their intestine. Whether this signifies early enteropathy-type intestinal T-cell lymphoma (EITCL) or reactive condition is not clear. We report on patient presenting the findings who subsequently developed overt EITCL. <i>Material and Methods:</i> Duodenal biopsies from 1997 (refractory sprue)...