A5082250518- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Health Promotion and Cardiovascular Prevention
- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Obesity and Health Practices
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes and associated disorders
- Primary Care and Health Outcomes
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Cardiac Health and Mental Health
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Mobile Health and mHealth Applications
- Pesticide Exposure and Toxicity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Clinical practice guidelines implementation
- Heart Rate Variability and Autonomic Control
- Parkinson's Disease Mechanisms and Treatments
- Nutrition, Genetics, and Disease
Aarhus University
2016-2025
Steno Diabetes Centers
2019-2025
Aarhus University Hospital
2019-2025
Danish National Institute of Public Health
2012-2023
The Capital Region Pharmacy
2023
Central Denmark Region
2019-2020
Public Health Department
2012
University of Southern Denmark
2011
Odense University Hospital
1995-1999
OBJECTIVE—Three independent studies have shown that variation in the fat mass and obesity-associated (FTO) gene associates with BMI obesity. In present study, effect of FTO on metabolic traits including obesity, type 2 diabetes, related quantitative phenotypes was examined. RESEARCH DESIGN AND METHODS—The rs9939609 polymorphism genotyped a total 17,508 Danes from five different study groups. RESULTS—In 3,856 diabetic case subjects 4,861 normal glucose-tolerant control subjects, minor...
To estimate the benefits of screening and early treatment type 2 diabetes compared with no late using a simulation model data from ADDITION-Europe study.We used Michigan Model, validated computer model, study to absolute risk cardiovascular outcomes relative reduction associated intensive treatment, routine 3- or 6-year delay in diagnosis factors.When was programmed baseline demographic clinical characteristics population, it accurately predicted empiric results trial. The simulated were...
The role of glucose-stimulated release GLP-1 in the development obesity and type 2 diabetes is unclear. We assessed response to oral glucose a large study population lean obese men women with normal impaired regulation. Circulating concentrations glucose, insulin, during an tolerance test (OGTT) were analyzed individuals (NGT) (n = 774), prediabetes 525), or screen-detected 163) who attended Danish ADDITION-PRO 1,462). Compared NGT, had 25% lower OGTT, both 16-21% 120-min independent age...
OBJECTIVE—To develop a simple self-administered questionnaire identifying individuals with undiagnosed diabetes sensitivity of 75% and minimizing the high-risk group needing subsequent testing. RESEARCH DESIGN AND METHODS—A population-based sample (Inter99 study) 6,784 aged 30–60 years completed on diabetes-related symptoms risk factors. The participants underwent an oral glucose tolerance test. score was derived from first half validated second study population. External validation...
In the present study, we aimed to validate type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well intergenic rs9300039 variant. Furthermore, characterize quantitative metabolic risk phenotypes of four variants.The variants were genotyped population-based Inter99 cohort (n = 5,970), ADDITION Study 1,626), a sample young healthy subjects 377), additional diabetic...
A major question in evolutionary biology is how natural selection has shaped patterns of genetic variation across the human genome. Previous work documented a reduction diversity regions genome with low recombination rates. However, it unclear whether other summaries variation, like allele frequencies, are also correlated rate and these correlations can be explained solely by negative against deleterious mutations or positive acting on favorable alleles required. Here we attempt to address...
It has been hypothesized that, in aggregate, rare variants coding regions of genes explain a substantial fraction the heritability common diseases. We sequenced exomes 1,000 Danish cases with forms type 2 diabetes (including body mass index > 27.5 kg/m2 and hypertension) healthy controls to an average depth 56×. Our simulations suggest that our study had statistical power detect at least one causal gene (a containing mutations) if these diseases was explained by limited number genes. applied...
Periodontitis is a common finding among people with diabetes mellitus (DM) and has been cited as DM complication. Whether how periodontitis relates to other diabetes-related complications yet be explored. This study aims examine the clustering of explore pathways linking risk factors. Using data from participants across 3 cycles National Health Nutrition Examination Survey (NHANES) (n = 2,429), we modeled direct indirect factors complications, latent construct comprising periodontitis,...
To validate two register-based algorithms classifying type 1 (T1D) and 2 diabetes (T2D) in a general population using Danish register data.After linking data on prescription drug usage, hospital diagnoses, laboratory results diabetes-specific healthcare services from nationwide registers, was defined for all individuals Central Denmark Region age 18-74 years 31 December 2018 according to distinct classifiers: 1) novel classifier incorporating diagnostic hemoglobin-A1C measurements, the...
There is limited evidence on how intensive multifactorial treatment (IT) improves outcomes of diabetes when initiated in the lead time between detection by screening and diagnosis routine clinical practice. We examined effects early IT type 2 primary care prevalence diabetic peripheral neuropathy (DPN) arterial disease (PAD) 6 years later a pragmatic, cluster-randomized parallel group trial.A stepwise program 190 general practices Denmark was used to identify 1,533 people with diabetes....
Objective. To examine whether training GPs in motivational interviewing (MI) can improve type 2 diabetic patients' (1) understanding of diabetes, (2) beliefs regarding prevention and treatment, (3) motivation for behaviour change. Methods. A randomized controlled trial including 65 265 patients. The were two groups, one with without MI training. Both groups received target-driven intensive treatment intervention was a 1½-day residential course ½-day follow-up twice during the first year....
Background Type 2 diabetes is an escalating public health problem in Nepal. The current study aims to assess the prevalence, associated factors, awareness, treatment, and control of type a semi-urban area Methods A population-based cross-sectional survey was conducted including 2,310 adults aged 25 years or above from Lekhnath Municipality Nepal, during October 2016 April 2017 using World Health Organization (WHO) STEPS approach. Data on demographics, behavioral risk blood pressure,...
There is continuing debate about the net benefits of population screening for type 2 diabetes. We compared risk cardiovascular disease (CVD) and mortality among incident cases diabetes in a screened group with those an unscreened group.In this register-based non-randomised controlled trial, eligible individuals were all men women aged 40-69 years without known diabetes, registered general practice Denmark (n = 1,912,392). Between 2001 2006, 153,107 181 practices participating...
BackgroundDespite advances in primary and secondary prevention of cardiovascular disease, excess mortality persists within the diabetes population. This study explores components this their interaction with sex.MethodsUsing Danish registries (2002–2019), we identified residents aged 18–99 years, status, recorded causes death. Applying Lexis-based methods, computed age-standardized rates (asMRs), relative risks (asMRRs), log-linear trends for cause-specific mortality.FindingsFrom 2002 to...
The Anglo-Danish-Dutch study of intensive treatment in people with screen-detected diabetes primary care (ADDITION) is a pragmatic randomised controlled trial the effectiveness intensified multi-factorial on 5 year cardiovascular morbidity and mortality rates type 2 Netherlands, UK Denmark. This paper describes baseline characteristics population, their estimated risk coronary heart disease extent to which that potentially modifiable.Stepwise screening strategies were performed using...