A5054114051- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Adipokines, Inflammation, and Metabolic Diseases
- Sodium Intake and Health
- Orthopedic Surgery and Rehabilitation
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Elbow and Forearm Trauma Treatment
- Estrogen and related hormone effects
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Adrenal and Paraganglionic Tumors
- Financial Literacy, Pension, Retirement Analysis
- Renin-Angiotensin System Studies
- Biochemical Analysis and Sensing Techniques
- Genetic Associations and Epidemiology
- Cardiovascular Syncope and Autonomic Disorders
- Shoulder Injury and Treatment
- Medication Adherence and Compliance
- Cardiovascular and exercise physiology
- Pharmaceutical Practices and Patient Outcomes
Tokai University Hachioji Hospital
2010-2025
Uji Hospital
2025
Shonan Institute of Technology
2025
National Sagamihara Hospital
2012-2024
Keio University
2012-2023
Tokai University
2003-2023
Bank of Japan
2023
International Monetary Fund
2014-2017
National Institute of Technology, Kumamoto College
2017
Ministry of Finance
2014-2016
Adiponectin, which is secreted specifically by adipose tissue, has been shown to act as an anti-atherosclerotic protein direct effects on endothelial cells. Clinical studies have that adiponectin levels are lower in individuals with obesity, diabetes and coronary artery disease. The present study investigated relationships between serum body mass index (BMI), blood pressure, insulin resistance index, lipid profile, uric acid high-sensitivity C-reactive a large number of Japanese subjects not...
Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure spontaneously hypertensive rats and humans. The authors examined the pressure-lowering effect safety of CGA patients with mild hypertension through a placebo-controlled, randomized clinical trial. Subjects (n=28) were to receive treatment (140 mg/day) from GCE or placebo. Blood pressure, pulse rate, body mass index, routine test, hematochemistry, urinalysis, subjective symptoms recorded throughout study. In...
It has been reported that the serum adiponectin level was negatively correlated with body mass index (BMI), insulin resistance index, and triglycerides positively high-density lipoprotein cholesterol in several cross-sectional studies. However, causal relationship not elucidated. We investigated whether baseline could predict subsequent changes resistance, lipid profile, or weight a 2-yr longitudinal study. This study included 590 male Japanese subjects, aged 30-65 yr, who received annual...
Epidemiologic studies indicate that ingestion of vegetables and fruit inhibits the development cardiovascular disease. Chlorogenic acids are abundant phenolic compounds contained in fruits, but impact dietary chlorogenic on vascular function hypertension is not known. We therefore examined effects 5-caffeoylquinic acid (CQA), a representative acid, blood pressure age-matched normotensive Wistar-Kyoto rats spontaneously hypertensive rats.A single CQA (30-600 mg/kg) reduced rats, an effect was...
Few studies have evaluated out-of-office blood pressure (BP) measurements as predictors of coronary artery disease (CAD) events.The aim this study was to determine morning home (HBP) a predictor CAD events.Using data from the HONEST (Home measurement with Olmesartan Naive patients Establish Standard Target pressure) study, we investigated relationship between HBP and incidence stroke events.In 21,591 treated hypertensive (mean age 64.9 years; mean follow-up 2.02 years), 127 events (2.92 per...
This study aimed to investigate the relationship between on-treatment morning home blood pressure (HBP) and incidence of cardiovascular events using data from Home Blood Pressure Measurement With Olmesartan Naive Patients Establish Standard Target (HONEST) study, a prospective observational 21 591 outpatients with essential hypertension (mean age, 64.9 years; women, 50.6%) enrolled 2009 2010 at clinics hospitals in Japan. They received olmesartan-based treatment throughout. The primary end...
Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10−8) in GWAS were further genotyped an independent samples (818 cases 1,032 controls) Korean (835 421 controls). SNP rs987870, located between HLA-DPA1 HLA-DPB1, was consistently associated 3 populations (Pcombined = 2.3×10−10, odds...
Adiponectin, which is secreted specifically by adipose tissue, has been shown to act as an anti-atherosclerotic protein direct effects on endothelial cells. Clinical studies have that adiponectin levels are lower in individuals with obesity, diabetes and coronary artery disease. The present study investigated relationships between serum body mass index (BMI), blood pressure, insulin resistance index, lipid profile, uric acid high-sensitivity C-reactive a large number of Japanese subjects not...
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phenolic compound contained in rice bran and other plants. The effect of ferulic on blood pressure (BP) was investigated spontaneously hypertensive rats (SHR). After oral administration (1 to 100 mg/kg) SHR, systolic (SBP) significantly decreased dose-dependent manner. When (50 administered BP lowest at 1 h returned basal levels 6 h. There significant correlation between SHR plasma changes the SBP tail artery, suggesting that absorbed...
To study whether there is an association between hypertension and hypothyroidism, measurements of blood pressure thyroid function were determined in 477 female patients with chronic thyroiditis. Based on the levels thyroxine (T4) stimulating hormone (TSH), 308 considered euthyroid 169 hypothyroid [T4 = 2.9 +/- 0.1 micrograms/dl TSH 105.8 6.8 microU/ml (mean SEM)]. Diastolic, but not systolic, over 50 years was higher than corresponding age groups. The prevalence when defined as systolic...
ABSTRACT To study whether the renin‐angiotensin system is related to hyperuricemia in hypertension, serum concentration of uric acid was determined 96 patients with various types hypertension and degrees plasma renin activity (PRA). In malignant both PRA level were higher than essential hypertension; but primary aldosteronism or desoxycorticosterone‐excess they lower type. renovascular levels similar. There no differences between Cushing's syndrome hypertension. The high‐renin either...
Recent genome wide association (GWA) studies on European and American populations revealed with lung cancer risk of single-nucleotide polymorphisms (SNPs) in the locus containing two nicotine acetylcholine receptor (CHRNA) genes, whose involvement tobacco addiction had been indicated. Association smokers was consistently, but that non-smokers as well smoking behavior inconsistently, observed these studies. To obtain further information significance CHRNA SNPs risk, seven this status examined...