Stefan T. Engelter
A5064472070- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Cervical and Thoracic Myelopathy
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and genetic disorders
- Cardiovascular Issues in Pregnancy
- Neurological Complications and Syndromes
- Peripheral Artery Disease Management
- Connective tissue disorders research
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Aortic Disease and Treatment Approaches
- Neurological Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular and Diving-Related Complications
- Genetic Associations and Epidemiology
- Neurological Disorders and Treatments
University Hospital of Basel
2016-2025
University of Basel
2016-2025
Felix Platter-Hospital
2016-2025
Hospital Base
2003-2024
Biomedical Research Institute
2022-2024
Hospital de Sant Pau
2022-2024
University College London
2012-2024
Brown University
2024
Instituto Nacional de Neurología y Neurocirugía
2024
University of British Columbia
2024
Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach more effective than t-PA alone uncertain.
In a geographically defined population, we assessed incidence and determinants of aphasia attributable to first-ever ischemic stroke (FEIS).A 1-year prospective, population-based study among the permanent residents canton Basle City, Switzerland, was performed using multiple overlapping sources information.Among 188,015 inhabitants, 269 patients had FEIS, whom 80 (30%; 95% CI, 24 36) aphasia. The overall rate FEIS amounted 43 per 100,000 inhabitants (95% 33 52). Aphasic were older than...
BackgroundThe International Carotid Stenting Study (ICSS) of stenting and endarterectomy for symptomatic carotid stenosis found a higher incidence stroke within 30 days compared with endarterectomy.We aimed to compare the rate ischaemic brain injury detectable on MRI between two groups.Methods Patients recently artery enrolled in ICSS were randomly assigned 1:1 ratio receive or endarterectomy.Of 50 centres ICSS, seven took part substudy.The protocol specifi ed that was done 1-7 before...
Stenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy uncertain. We report data from the randomised International Carotid Study comparison these treatments.Patients with symptomatic stenosis were randomly assigned 1:1 open stenting or at 50 centres worldwide. Randomisation was computer generated centrally and allocated by telephone call fax. Major outcomes assessed independent endpoint committee unaware assignment. The primary fatal...
A study was undertaken to develop a score for assessing risk symptomatic intracranial hemorrhage (sICH) in ischemic stroke patients treated with intravenous (IV) thrombolysis.The derivation cohort comprised 974 (1995-2008) IV thrombolysis at the Helsinki University Central Hospital. The predictive value of parameters associated sICH (European Cooperative Acute Stroke Study II) evaluated, and we developed our according magnitude logistic regression coefficients. We calculated absolute risks...
<h3>Objective:</h3> To develop a functional outcome prediction score, based on immediate pretreatment parameters, in ischemic stroke patients receiving IV alteplase. <h3>Methods:</h3> The derivation cohort consists of 1,319 treated with alteplase at the Helsinki University Central Hospital, Helsinki, Finland. We evaluated predictive value parameters associated 3-month and developed score according to magnitude logistic regression coefficients. assessed accuracy model bootstrapping. External...
It is not known whether patients with atrial fibrillation (AF) ischemic stroke despite oral anticoagulant therapy are at increased risk for further recurrent strokes or how ongoing secondary prevention should be managed.
The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-based recommendations on management extracranial artery dissection (EAD) and intracranial (IAD). EAD IAD represent leading causes stroke in young, but are uncommon general population, thus making it challenging conduct clinical trials large observational studies. guidelines were prepared following Standard Operational Procedure for according GRADE methodology. Our four result from a...
Cervical artery dissection is an important cause of stroke, particularly in young adults. Data conflict on the diagnostic evaluation and treatment patients with suspected cervical dissection, leading to variability practice. We aim provide overview setting minor or no reported mechanical trigger a focus summarizing available evidence providing suggestions evaluation, approaches, outcomes. Writing group members drafted their sections using literature search focused publications between...
Small, randomized trials of patients with cervical artery dissection showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in treated antiplatelets versus anticoagulation.
Early prediction of outcome in patients with ischemic stroke is important. Vasopressin a stress hormone. Its production rate mirrored circulating levels copeptin, fragment provasopressin. We evaluated the prognostic value copeptin acute patients.In prospective observational study, was measured using new sandwich immunoassay on admission plasma 362 consecutive an stroke. The to predict functional (defined as modified Rankin Scale score <or=2 or >or=3), mortality within 90 days, compared...
To examine whether risk factor profile, baseline features, and outcome of cervical artery dissection (CEAD) differ according to the site.We analyzed 982 consecutive patients with CEAD included in Cervical Artery Dissection Ischemic Stroke Patients observational study (n = 619 internal carotid [ICAD], n 327 vertebral [VAD], 36 ICAD VAD).Patients were older (p < 0.0001), more often men 0.006), frequently had a recent infection (odds ratio [OR] 1.59 [95% confidence interval (CI) 1.09-2.31]),...
Intravenous thrombolysis for acute ischemic stroke is beneficial within 4.5 hours of symptom onset, but the effect rapidly decreases over time, necessitating quick diagnostic in-hospital work-up. Initial time strain occasionally results in treatment patients with an alternate diagnosis (stroke mimics). We investigated whether intravenous safe these patients.In this multicenter observational cohort study containing 5581 consecutive treated thrombolysis, we determined frequency and clinical...
Background and purpose Risk factors for IS in young adults differ between genders evolve with age, but data on the age‐ gender‐specific differences by stroke etiology are scare. These features were compared based individual patient from 15 European centers. Methods Stroke was reported detail 3331 patients aged 15–49 years first‐ever according to Trial of Org Acute Treatment ( TOAST ) criteria: large‐artery atherosclerosis LAA ), cardioembolism CE small‐vessel occlusion SVO other determined...