A5054607452- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Adrenal and Paraganglionic Tumors
- Heart Rate Variability and Autonomic Control
- Thyroid Disorders and Treatments
- Renin-Angiotensin System Studies
- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Nitric Oxide and Endothelin Effects
- Head and Neck Anomalies
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Thyroid and Parathyroid Surgery
- Eicosanoids and Hypertension Pharmacology
- Growth Hormone and Insulin-like Growth Factors
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Sodium Intake and Health
University of Brescia
2016-2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2014-2024
University of Milano-Bicocca
2024
Hospital do Servidor Público Estadual
2020
Medica (Italy)
1981-2017
Brescia University
1986-2014
Inserm
2011-2012
Université Paris Cité
2012
Centre National de la Recherche Scientifique
2012
Assistance Publique – Hôpitaux de Paris
2012
The presence of structural alterations in the microcirculation may be considered an important mechanism organ damage; however, it is not currently known whether small arteries predict fatal and nonfatal cardiovascular events.One hundred twenty-eight patients were included present study. There 59 with essential hypertension, 17 pheochromocytoma, 20 primary aldosteronism, 12 renovascular normotensive non-insulin-dependent diabetes mellitus. All subjects submitted to a biopsy subcutaneous fat....
Pheochromocytomas (PCC) and paragangliomas (PGL) are genetically heterogeneous neural crest-derived neoplasms. Recently we identified germline mutations in a new tumor suppressor susceptibility gene, MAX (MYC-associated factor X), which predisposes carriers to PCC. How contribute PCC/PGL associated phenotypes remain unclear. This study aimed examine the prevalence phenotypic features of somatic PCC/PGL.We sequenced 1,694 patients with PCC or PGL (without other major genes) from 17...
The aim of the study was to define frequency hereditary forms and genotype/phenotype correlations in a large cohort Italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas.We examined 501 consecutive paragangliomas (secreting nonsecreting). Complete medical family histories, as well results clinical, laboratory, imaging studies, were recorded database. Patients divided into different groups according their history, presence lesions outside...
The aim of the present study was to assess prognostic value changes in left ventricular hypertrophy hypertensive patients with time.Two hundred and fifteen uncomplicated underwent a high-quality baseline echocardiogram for anatomy evaluation 151 those echocardiographic examination repeated 10 +/- 1.4 years after initial study.Left mass index were evaluated, relation incidence non-fatal cardiovascular events, adjusted traditional risk factors.According presence or absence (left > 134 g/m2 men...
Left ventricular (LV) mass and geometry predict risk for cardiovascular events in hypertension. Regression of LV hypertrophy (LVH) may imply an important prognostic significance. The relation between changes during antihypertensive treatment subsequent prognosis has not yet been determined. A total 436 prospectively identified uncomplicated hypertensive subjects with a baseline follow-up echocardiogram (last examination 72±38 months apart) were followed additional 42±16 months. Their family...
Thyroid nodules are a common medical problem, but whether fine-needle aspiration cytology (FNAC) is mandated for smaller non-palpable nodules, controversial.To evaluate ultrasonographic features of thyroid associated with histological malignancy, and to identify useful criteria clinical decision-making.Prospective observational study.From January 1991 September 2004, 5198 patients were referred our hospital ultrasound evaluation nodules. Overall, 7455 (diameters from 6 100 mm) examined; 2865...
It has been proposed that several neurohumoral factors may be involved in the genesis of vascular structural changes (remodeling or hypertrophy) frequently observed essential hypertension. Therefore, this study we investigated alterations subcutaneous small resistance arteries patients with secondary forms The included 70 participants: 11 pheochromocytoma, 13 primary aldosteronism, and 17 renovascular hypertension; normotensive subjects 16 hypertension served as controls. All were submitted...
To evaluate if a nodule with shape taller than wide (anteroposterior/transverse diameter ratio, A/T > or = 1) is good predictor of malignancy independent the size.We retrospectively examined cytological and histological results 7455 nodules (5198 patients) referred for ultrasound-guided-fine needle aspiration cytology (US-FNAC) in our hospital from January 1991 to September 2004.A suitable FNAC was obtained 6135 (4495 patients); 34.6% were less 1 cm (small nodules, SN). A diagnosis carcinoma...
<h3>Context</h3> Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest–derived neoplasms. We recently identified germline mutations of the novel transmembrane-encoding gene<i>FP/TMEM127</i>in familial sporadic pheochromocytomas consistent with a tumor suppressor effect. <h3>Objectives</h3> To examine prevalence spectrum of<i>FP/TMEM127</i>mutations in to test effect vitro. <h3>Design, Setting, Participants</h3> sequenced the<i>FP/TMEM127</i>gene 990 individuals...
Little is known about the risk factors for cervical artery dissection (CEAD), a major cause of ischemic stroke (IS) in young adults. Hypertension, diabetes mellitus, smoking, hypercholesterolemia, and obesity are important IS. However, their specific role CEAD poorly investigated. Our aim was to compare prevalence vascular patients versus referents who suffered an IS other than (non-CEAD IS) multicenter Cervical Artery Dissection Ischemic Stroke Patients (CADISP) study.The study sample...
OBJECTIVE To assess the interplay between metformin treatment and thyroid function in type 2 diabetic patients. RESEARCH DESIGN AND METHODS The acute long-term effects of on axis hormones were assessed patients with primary hypothyroidism who either untreated or treated levothyroxine (L-T4), as well normal function. RESULTS No changes found 11 hypothyroidism. After 1 year administration, a significant thyrotropin (TSH) decrease (P &lt; 0.001) was observed subjects (n = 29; from 2.37 ±...
Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medullary thyroid carcinoma (MTC) associated 2A and 2B) or not familial MTC (FMTC) with other due to germline RET gene mutations. The prevalence of these rare diseases their corresponding mutations are unknown the small size study population.We collected data on 250 families hereditary followed in 20 different Italian centres.The most frequent amino acid substitution was Val804Met (19.6%) Cys634Arg (13.6%). A...
Background It has been reported that the D allele of an insertion/deletion ( I/D ) polymorphism angiotensin I–converting enzyme (ACE) gene is associated with conditions increased cardiovascular risk, including left ventricular hypertrophy. Methods and Results Considering a genetically determined overactivity renin-angiotensin system may influence cardiac as well vascular growth, we investigated possible relations between ACE genotype carotid artery wall thickness (B-mode ultrasound) in 199...
As a consequence of the increasing application ultrasound (US) technology, detection asymptomatic nonpalpable thyroid nodules has generally increased. The aim our study was to assess if anteroposterior and transverse diameter ratio (A/T) > or = 1 could be sonographic criterion for recommending fine-needle aspiration cytology (FNAC).From January 2002 2004, 828 consecutive solid were evaluated by ultrasonography, colour-Doppler FNAC in department. Cases selected from 2217 patients, referred...
Abstract Background Papillary thyroid carcinoma (PTC) represents 70%–75% of well‐differentiated cancers. Although most reports have shown that papillary microcarcinomas (PMC) follow an indolent course, a few series demonstrated significant number them are associated with extrathyroidal extension and nodal or distant metastases. Methods Four hundred eighty‐four patients cancer (102, PMC; 382, PTC) were enrolled in this study. The median follow‐up was 102 months. Results No difference between...
Assessment of appropriateness left ventricular mass (LVM) for a given workload may better stratify hypertensive patients. Inappropriate LVM reflect the interaction genetic and neurohumoral factors other than blood pressure playing significant role in myocardial growth. Primary aldosteronism (PA) represents clinical model useful assessing effect aldosterone increase on LVM. The aim this study was to evaluate inappropriateness patients with PA. In 125 PA (54 females; adrenal hyperplasia 73...
Objective: Pregnancy and the postpartum (PP) period are associated with profound changes of immune system, which largely influence clinical activity autoimmune diseases. The aim this study was to evaluate effect pregnancy and/or PP in driving a relapse hyperthyroidism patients Graves’ disease (GD) who remission after antithyroid drug (ATD) treatment. Data were retrospectively collected from 150 female GD, assigned two groups according occurrence successful ATD withdrawal. Results: Relapsing...
A retrospective study to evaluate the changes in TSH concentrations diabetic patients treated or not with metformin and/or L-thyroxine (L-T(4)).Three hundred and ninety three euthyroid were divided into groups on basis of L-T(4) treatment: Group (M-/L-), 119 subjects never L-T(4); (M+/L-), 203 who started treatment at recruitment; (M+/L+), 71 recruitment.The effect serum was analyzed relation basal value (below 2.5 mIU/L (Q1) between 2.51 4.5 (Q2)). In group M+/L+, significantly decreased...
Background: Levothyroxine (LT4) is the recommended treatment for millions of hypothyroid patients. Current guidelines recommend that LT4 tablets be taken in a fasting state, but inability to adhere this often leads poor therapy compliance. Methods: A randomized, double-blind, placebo-controlled, crossover trial was conducted previously untreated patients randomly assigned receive an oral solution either at least 30 minutes before breakfast or directly time. Each patient completed two...
In the age of Evidence-Based Medicine, Clinical Guidelines (CGs) are recognized to be an indispensable tool support physicians in their daily clinical practice. Medical Informatics is expected play a relevant role facilitating diffusion and adoption CGs. However, past pioneering approaches, often fragmented many disciplines, did not lead solutions that actually exploited hospitals. Process Mining for Healthcare (PM4HC) emerging discipline gaining interest healthcare experts, seems able deal...
The angiotensin II type 1 (AT1) receptor has a key role in mediating the vasoconstrictor and growth-promoting effects of II. It been reported that polymorphism AT1 gene (an A/C transversion at position 1166) may be associated with cardiovascular phenotypes, such as arterial blood pressure aortic stiffness, underlie condition increased risk. We examined sample 212 subjects randomly selected from general population northern Italy to investigate polymorphism, regulation growth. measured (both...