A5017012708- Nutrition and Health in Aging
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Nutrition and Gastroenterology
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Appendicitis Diagnosis and Management
- Frailty in Older Adults
- Colorectal Cancer Screening and Detection
- Blood transfusion and management
- Neuroendocrine Tumor Research Advances
- Anesthesia and Pain Management
- Abdominal Surgery and Complications
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Hernia repair and management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gastrointestinal Tumor Research and Treatment
- Erythropoietin and Anemia Treatment
- Diverticular Disease and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Milano-Bicocca
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
1990-2025
Azienda Ospedaliera San Gerardo
2019-2025
Vita-Salute San Raffaele University
2012-2024
Mylan (South Africa)
2024
University of Ferrara
2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
1990-2024
ORCID
2021-2022
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
1996-2021
Ospedale Sandro Pertini
2021
Application of evidence-based perioperative care protocols reduces complication rates, accelerates recovery and shortens hospital stay. Presently, there are no comprehensive guidelines for gastrectomy.An international working group within the Enhanced Recovery After Surgery (ERAS®) Society assembled an framework optimal patients undergoing gastrectomy. Data were retrieved from standard databases personal archives. Evidence recommendations classified according to Grading Recommendations,...
Pancreatic cancer is a very aggressive disease characterized by marked desmoplasia with predominant Th2 (GATA-3+) over Th1 (T-bet+) lymphoid infiltrate. We found that the ratio of GATA-3+/T-bet+ tumor-infiltrating cells an independent predictive marker patient survival. Patients surgically treated for stage IB/III inferior to median value had statistically significant prolonged overall survival, implying active role responses in progression. Thymic stromal lymphopoietin (TSLP), which favors...
The primary endpoint was to compare the impact of laparoscopic and open colorectal surgery on 30-day postoperative morbidity. Lymphocyte proliferation mitogens gut oxygen tension were surrogate endpoints.Evidence-based proof effect immunometabolic response clinically relevant outcome variables is scanty. Further randomized trials are desirable before proposing laparoscopy as a superior technique.Two hundred sixty-nine patients with disease randomly assigned (n = 136) or 133) resection. Four...
<h3>Hypothesis</h3> Perioperative administration of a supplemented enteral formula may decrease postoperative morbidity. <h3>Design</h3> Randomized clinical trial. <h3>Setting</h3> Department surgery at university hospital. <h3>Patients</h3> One hundred ninety-six registered malnourished patients (weight loss ≥10%) who were candidates for major elective malignancy the gastrointestinal tract. <h3>Intervention</h3> After randomization (n = 150), one group received feeding with standard diet...
Objective The primary endpoint was to compare the impact of laparoscopic and open colorectal surgery on 30-day postoperative morbidity. Lymphocyte proliferation mitogens gut oxygen tension were surrogate endpoints. Summary Background Data Evidence-based proof effect immunometabolic response clinically relevant outcome variables is scanty. Further randomized trials are desirable before proposing laparoscopy as a superior technique. Methods Two hundred sixty-nine patients with disease randomly...
Abstract Background Data on enhanced recovery programmes after pancreatic surgery are sparse. This retrospective cohort study, using historical controls, aimed to evaluate the impact of a fast-track programme pancreaticoduodenectomy (PD). Methods Between 2004 and 2007, 252 patients undergoing PD were treated by that included earlier postoperative feeding mobilization. The compared with an equally sized control group received traditional from 2000 2004. Outcome measures morbidity, length stay...
Abstract Background Analytical morphometric assessment has recently been proposed to improve preoperative risk stratification. However, the relationship between body composition and outcomes following pancreaticoduodenectomy is still unclear. The aim of this study was assess impact on in patients undergoing for cancer. Methods Body parameters including total abdominal muscle area (TAMA) visceral fat (VFA) were assessed by staging CT Perioperative variables postoperative (mortality or...
Perioperative administration of a supplemented enteral formula may reduce the rate postoperative infections.Prospective, randomized, double-blind clinical trial.Department surgery at university hospital.Two hundred six patients with neoplasm colorectum, stomach, or pancreas.Patients were randomized to drink 1 L/d either control (n = 104) same enriched arginine, RNA, and omega3 fatty acids 102) for 7 consecutive days before surgery. The 2 diets isoenergetic isonitrogenous. Jejunal infusion...
Objective To evaluate the potential clinical, metabolic, and economic advantages of enteral nutrition over total parenteral nutrition. Design Prospective, randomized clinical trial. Setting Department surgery in a university hospital. Patients Two hundred fifty-seven patients with cancer stomach (n = 121), pancreas 110), or esophagus 26) were to receive postoperative (TPN group, n 131) early (EEN 126). The nutritional goal was 25 kcal/kg/day. two formulas isocaloric isonitrogenous, they...
PURPOSE: The aim of this study was to evaluate the reliability intraoperative laser-Doppler measurements in predicting occurrence anastomotic leak patients with colorectal cancer undergoing stapled straight anastomosis rectum. METHODS: A prospective undertaken on 55 rectal or distal sigmoid programmed for elective curative surgery. In all transmural colonic blood flow measured by flowmetry technique before bowel manipulation (baseline measurement) and after vascular ligation division....
Purpose: This study was designed to evaluate the impact of laparoscopic rectal resection on short-term postoperative morbidity and costs. Methods: A total 168 patients with cancer were randomly assigned (n = 83) or open 85) resection. Outcome parameters were: morbidity, length hospital stay, quality life, long-term survival, local recurrences. The mean follow-up period 53.6 months. Cost-benefit analysis based Results: Operative time 53 minutes longer in group (P< 0.0001). Postoperative rate...
The purpose of this study was to evaluate the impact laparoscopic colorectal resection on short-term postoperative outcome in elderly patients.A series 535 patients with disease who had been randomly assigned (n=268) or open (n=267) analyzed. A total 201 (37.6 percent) were (aged 70 years older) and 334 (62.4 younger than aged years. Follow-up for morbidity performed 30 days after hospital discharge.Elderly a higher American Society Anesthesiologists score compared both groups (P=0.0001). In...
To develop and validate a simple prognostic score to predict major postoperative complications after pancreaticoduodenectomy (PD).PD still carries high rate of severe complications. No specific is currently available stratify the patient's risk morbidity.Between 2002 2010, preoperative, intraoperative, outcome data from 700 consecutive patients undergoing PD in our institution were prospectively collected an electronic database. Major defined as levels III V Clavien-Dindo classification. On...
This study was designed to evaluate long-term complications, quality of life, and survival rate in a series colorectal cancer patients randomized laparoscopic or open surgery.A total 391 with were randomly assigned (n = 190) 201) resection. Long-term follow-up performed every six months by office visits. Quality life assessed at 12, 24, 48 after surgery modified version Short Form 36 Health Survey questionnaire. All analyzed on an intention-to-treat basis.Eight (4.2 percent) group needed...