A5012759631- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Frailty in Older Adults
- Advanced Combustion Engine Technologies
- Body Composition Measurement Techniques
- Cancer, Lipids, and Metabolism
- Combustion and flame dynamics
- Cancer Risks and Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Vehicle emissions and performance
- Aluminum Alloy Microstructure Properties
- RNA modifications and cancer
- Aluminum Alloys Composites Properties
- GDF15 and Related Biomarkers
- Biodiesel Production and Applications
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Dialysis and Renal Disease Management
- Nutritional Studies and Diet
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
Peking University
2021-2025
Aerospace Center Hospital
2024-2025
Jiangxi University of Traditional Chinese Medicine
2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Chongqing Jiulongpo People's Hospital
2024
South China University of Technology
2023-2024
Zhengzhou Central Hospital
2020-2024
China International Science and Technology Cooperation
2020-2023
Background Colorectal cancer (CRC) is among the most common malignant cancers worldwide, and its development influenced by inflammation, nutrition, immune status. Therefore, we combined C-reactive protein (CRP), albumin, lymphocyte, which could reflect above status, to be CRP-albumin-lymphocyte (CALLY) index, evaluated association with overall survival (OS) in patients CRC. Methods The clinicopathological laboratory characteristics of 1260 CRC were collected from Investigation on Nutrition...
Ferroptosis, featuring an iron‐dependent peroxidation of lipids, is a novel form programmed cell death that may hold great potential in cancer therapy. Our study found palmitic acid (PA) inhibited colon viability vitro and vivo , conjunction with accumulation reactive oxygen species lipid peroxidation. The ferroptosis inhibitor Ferrostatin‐1 but not Z‐VAD‐FMK (a pan‐caspase inhibitor), Necrostatin‐1 potent necroptosis or CQ autophagy), rescued the phenotype induced by PA. Subsequently, we...
Although systemic inflammation is an important feature of the cancer cachexia, studies on association between and prognostic cachexia are limited. The objective this study to evaluate whether neutrophil-to-lymphocyte ratio (NLR) associated with outcome quality life for patients investigated any interaction NLR clinical parameters.This a multicentre cohort 2612 suffering from diagnosed June 2012 December 2019. main parameters measured were overall survival (OS) time all-cause mortality....
Abstract Gasoline compression ignition (GCI) engines are considered an attractive alternative to traditional spark-ignition and diesel engines. In this work, a Machine Learning-Grid Gradient Ascent (ML-GGA) approach was developed optimize the performance of internal combustion ML offers pathway transform complex physical processes that occur in engine into compact informational processes. The ML-GGA model compared with recently Learning-Genetic Algorithm (ML-GA). Detailed investigations...
Abstract Backgrounds Hand grip strength (HGS) is one of diagnose criteria factors sarcopenia and associated with the survival patients cancer. However, few studies have addressed association HGS 1 year mortality cancer cachexia. Methods This cohort study included 8466 malignant solid tumour from 40 clinical centres throughout China. Cachexia was diagnosed using 2011 International cachexia consensus. The hazard ratio (HR) all calculated Cox proportional regression models. Kaplan–Meier curves...
There is considerable research value and extensive application perspectives to explore the link between gut microbiota heart failure. The purpose of this study provide an overview overall characteristics, evolutionary pathways, frontier hotspots, future trends in field.Research datasets were acquired from Web Science Core Collection (WoSCC) January 1, 2006 December 31, 2021. Three different analysis tools including one online platform, VOS viewer V1.6.17.0, CiteSpace V5.8.R2 software used...
The aim of our work is to clarify the clinical implication and functional role tripartite motif 21 (TRIM21) in hepatocellular carcinoma (HCC). We validated that TRIM21 was downregulated liver cancer samples by immunohistochemical (IHC) staining. also demonstrated its downregulation associated with several clinicopathologic features such as tumor numbers, T stage, Barcelona Clinic Liver Cancer (BCLC) Italian Program (CLIP) stage HCC patients. Importantly, expression significantly correlated...
Recently, albumin-globulin ratio (AGR), a serological indicator that reflects nutritional status and systemic inflammatory, has been reported to be associated with the prognosis of various cancers. However, there is currently no research report on its relationship cancer cachexia.
Objective Systemic inflammation and malnutrition are correlated with cancer sarcopenia have deleterious effects on oncological outcomes. However, the combined effect of in patients remains unclear. Methods We prospectively collected information 1,204 diagnosed sarcopenia. mean (SD) age was 64.5 (11.4%) years, 705 (58.60%) were male. The categorized into high advanced lung index (ALI) group (≥18.39) low ALI (<18.39) according to optimal survival cut-off curve. selected marker using...
Body water measured by bioelectrical impedance analysis (BIA) predicts the outcomes of many diseases. This study aimed to evaluate relationship between body and prognosis cancer patients with sarcopenia.This employed 287 sarcopenia underwent BIA from a prospective multicenter in China 2013 2020. The primary outcome interest was all-cause mortality presented as longest time follow-up available. Eight indicators [total water, extracellular intracellular free fat mass, active cell...
Abstract Penetration of immune cells into tumor was believed to be immune-suppressive via cell-in-cell (CIC) mediated death the internalized cells. We unexpectedly found that CIC formation largely led host cells, but not manifesting typical features executed by NK cells; we named this “in-cell killing” which displays efficacy superior canonical way “kiss-killing” from outside. By profiling isogenic CD44 on identified as a negative regulator inhibiting formation. functions antagonize cell...
Abstract Background Changes in body composition and systemic inflammation are important characteristics of cancer cachexia. This multi‐centre retrospective study aimed to explore the prognostic value combination patients with Methods The modified advanced lung index (mALI), which combines inflammation, was defined as appendicular skeletal muscle (ASMI) × serum albumin/neutrophil‐lymphocyte ratio. ASMI estimated according a previously validated anthropometric equation. Restricted cubic...
<title>Abstract</title> <bold>Objectives:</bold> Pulmonary arterial hypertension (PAH) is a chronic vascular disorder characterized by elevated pulmonary artery pressure and resistance, which can ultimately result in right ventricular failure. This condition imposes substantial economic burden significant health challenges on both healthcare systems patients. The objective of this study was to conduct comprehensive analysis the global PAH, evaluating factors such as gender, age, region,...
Abstract Background Cardiovascular diseases (CVD) represent a major global health challenge, necessitating up-to-date data on its burden for effective care planning and resource allocation. This study comprehensively analyzes the global, regional, national CVD associated risks from 1990 to 2021. Methods Results We performed secondary analysis of risk factors using Global Burden Disease (GBD) 2021 study. In 2021, there were 612 million cases globally, accounting 26.8% all deaths. From...
UBA1 and UBA6 are classic ubiquitin-activating E1 enzymes, which participate in the ubiquitination degradation of intracellular proteins closely related to occurrence development various diseases tumors. However, at present, comprehensive analysis has not been used study role UBA family cancers. We extracted relevant data cancer patients from TCGA database studied relationship between expression patterns survival rate, stage pan-cancer, especially breast (BRCA), colorectal (COAD), renal...
Introduction Accurate diagnosis of Pneumocystis jirovecii pneumonia (PJP) in HIV patients remains challenging. This study compares metagenomic next-generation sequencing (mNGS) with PCR, GMS staining, and serum β-D-glucan (BG) assays for PJP detection co-infection identification. Methods BALF samples from 34 HIV-positive 50 non-PJP controls were analyzed. Diagnostic performance metrics (sensitivity, specificity, NPV, AUC) co-pathogen profiles evaluated mNGS versus conventional methods....