A5073439466- MicroRNA in disease regulation
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Hernia repair and management
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Sirtuins and Resveratrol in Medicine
- Thyroid Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Head and Neck Anomalies
- Gastric Cancer Management and Outcomes
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- RNA Research and Splicing
- Advanced Nanomaterials in Catalysis
Southern Medical University
2015-2025
Guangdong Provincial People's Hospital
2015-2024
Jinan University
2024
Second Affiliated Hospital of Guangzhou Medical University
2022
Guangzhou Medical University
2022
Chinese General Hospital College of Nursing and Liberal Arts
2020
Chinese People's Liberation Army
2020
State Council of the People's Republic of China
2018
Pingjin Hospital
2016
Chinese People's Armed Police Force
2016
Background: There is increasing evidence that tumour-associated macrophages (TAMs) are critical in the formation of lung metastases.However, molecular mechanisms tumour interactions with TAMs via EMT largely unknown.Methods: The mechanism metastasis was studied patient tissues.The SNAIL regulation interaction between mesenchymal cells and M2 elucidated using coculture Transwell assays vitro vivo nude mice NOD-SCID mice.Results: We demonstrated for first time CXCL2 were abnormally...
The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate patients. efficacy current treatment strategies is low as usually initiated following onset symptoms. Inflammation one main mechanisms autoimmune disorders and a common feature sepsis. suppression inflammation therefore an important mechanism for Sirtuin 1 (Sirt1) has been demonstrated to play role in regulation inflammation. Resveratrol, potent Sirt1 activator, exhibits anti‑inflammatory properties....
The aim of this study is to clarify the clinical implication and functional role structure specific recognition protein 1 (SSRP1) in hepatocellular carcinoma (HCC) explore underlying mechanism aberrant high expression SSRP1 cancers. In present investigation, we validated that was upregulated HCC samples. We also demonstrated its upregulation associated with several clinicopathologic features such as higher serum AFP level, larger tumor size, T stage patients; indicated shorter overall...
The aim of our work is to clarify the clinical implication and functional role tripartite motif 21 (TRIM21) in hepatocellular carcinoma (HCC). We validated that TRIM21 was downregulated liver cancer samples by immunohistochemical (IHC) staining. also demonstrated its downregulation associated with several clinicopathologic features such as tumor numbers, T stage, Barcelona Clinic Liver Cancer (BCLC) Italian Program (CLIP) stage HCC patients. Importantly, expression significantly correlated...
Apatinib recently has been used to treat patients with gastric cancer, but the function of apatinib in colon cancer remains unclear. This study was conducted investigate impacts on biological and its potential mechanism cells
Abstract In this study, microarray data analysis, real‐time quantitative PCR and immunohistochemistry were used to detect the expression levels of SSRP1 in colorectal cancer (CRC) tissue corresponding normal tissue. The association between structure‐specific recognition protein 1 (SSRP1) patient prognosis was examined by Kaplan‐Meier analysis. knocked down overexpressed CRC cell lines, its effects on proliferation, cycling, migration, invasion, cellular energy metabolism, apoptosis,...
Abstract Gastric cancer (GC) is one of the most common malignancies and its prognosis extremely poor. This study identifies a novel oncogene, microfibrillar-associated protein 2 (MFAP2) in GC. With integrative reanalysis transcriptomic data, we found MFAP2 as GC prognosis-related gene. And aberrant expression was explored samples. Subsequent experiments indicated that silencing exogenous could affect motility cells. The inhibition be rescued by another FAK activator, fibronectin. process...
Abstract Background X‐linked inhibitor of apoptosis protein (XIAP) is a member the family proteins and deregulation XIAP can result in tumorigenicity. The objective this study was to evaluate prognostic significance expression colorectal cancer (CRC). Methods RT‐PCR performed detect mRNA CRC cells tissues. tissues measured by immunohistochemistry. correlation with clinicopathologic factors prognosis patients evaluated. Results showed significantly higher levels than normal human intestinal...
Background Tumor recurrence is a major problem after curative resection of hepatocellular carcinoma (HCC). The current study evaluated the effects adjuvant iodine-125 (125I) brachytherapy on postoperative HCC. Methodology/Principal Findings From July 2000 to June 2004, 68 HCC patients undergoing hepatectomy were randomly assigned into 125I group (n = 34) and best care 34). Patients in received seed implantation raw surface resection. control identical treatments except for implantation. Time...
[This retracts the article DOI: 10.1039/C8RA05132A.].
Abstract Circular RNAs feature prominently in cancer development. Nonetheless, the role of circ_0072088 hepatocellular carcinoma (HCC) remains unclear. GEO databases (GSE97332, GSE108724, GSE36915, and GSE33006) were used to screen out differentially expressed circRNAs, miRNAs, mRNA HCC. The expressions circ_0072088, miR‐375, Janus Kinase 2 (JAK2) HCC tissue cell lines determined with quantitative real‐time polymerase chain reaction. RNase R treatment assay was measure stability subcellular...
The change of bacterial flora structure in colorectal cancer (CRC) patients after treatment is not clear. aim this study was to explore the and function intestinal microflora CRC before treatment.The 16S conserved region V3+V4 obtained from sequenced analyzed. Alpha beta diversity indices were used analyze abundance gut flora. FAPROTAX, BugBase, Tax4Fun software species phenotypes Kyoto Encyclopedia Genes Genomes Ontology (KO) pathways.Total significantly increased compared with healthy...
Structure-specific recognition protein 1 (SSRP1) has been considered as a potential biomarker, since aberrant high expression of SSRP1 detected in numerous malignant tumors. However, the correlation between level and glioma remains unclear. The present study attempted to investigate role pathogenesis glioma. In study, our data revealed that overexpression was tissues at both mRNA levels using quantitative real-time RT-PCR immunohistochemical analysis. We also demonstrated upregulated...
Objective Titanium oxide (TiO 2 ) acts as a photosensitizer in photodynamic therapy by mediating reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress. This study aimed to investigate the effect of TiO on ER stress liver cancer cells. Methods Normal human and hepatocarcinoma cell lines were incubated with various concentrations nanotubes for 48 hours. Cell growth, apoptosis, cycle, cellular ROS detected. Expression levels sensors (PERK ATF6) Bax evaluated western blot. The...
Gastric cancer (GC) is one of the most common types gastrointestinal tumors worldwide, and side effects chemotherapeutic drugs resistance to chemotherapy remain problematic in its clinical treatment. Therefore, safe effective novel agents are urgently required. The purpose present study was investigate crocetin‑sensitive treatment GC possible mechanisms. BGC‑823 human cells were treated with crocetin. crocetin on viability determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...
Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation human telomerase reverse transcriptase (hTERT) frequently occurs is being considered as a in diagnosis treatment. siRNA sequence that hTERT mRNA can silence the gene reduce protein expression to cell proliferation inhibit growth. our study, we tested matrix metalloproteinase-2 (MPP2) aCPP delivering...
Widespread applications of nanosized materials over the past decade have prompted investigations desirable properties and potential hazards to humans environment. Titanium dioxide (TiO2) nanoparticles are one most widely used nanoparticles. To investigate effect biological functions induced by TiO2 (10 nm: NPs) on human liver cell lines, normal line L02 hepatoma HepG2 were co-cultured with exogenous NPs. Cell growth proliferation, cycle, apoptosis rate analyzed. The effects NPs expression...
Objective: The aim of this study was to assess whether the median or lateral umbilicus ligament covering internal hernia opening region after purse-string knot could eliminate recurrence in laparoscopic inguinal repair pediatric patients all ages. Methods: About 482 repairs 428 children various ages were prospectively our institution from January 2000 2004. divided into two groups randomly. In group A, accepted closing only; B, knot. data both operations then compared. Results: A total 239...
At present, apatinib is considered a new generation agent for the treatment of patients with gastric cancer. However, effects on pancreatic cancer have not been clarified. This study investigated impact biological function cells and potential mechanism involved in this process. Using Cell Counting Kit-8 method, we confirmed that inhibited cell proliferation vitro . Moreover, migration rate was inhibited. The apoptosis cycle distribution carcinoma were detected by flow cytometry. number...
Many aberrantly expressed circular RNAs (circRNAs) play important roles in the development and progression of hepatocellular carcinoma (HCC). However, exact function circ_0001175 HCC cells is unknown. Our study aimed to investigate expression characteristics its effects on proliferation, migration invasion cells, explore potential mechanism.Quantitative real-time polymerase chain reaction (qRT-PCR) Western blot were carried out detect circ_0001175, microRNA-130a-5p (miR-130a-5p) sorting...