A5101775832- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Single-cell and spatial transcriptomics
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Medicinal Plant Pharmacodynamics Research
- TGF-β signaling in diseases
- Cancer, Hypoxia, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Melanoma and MAPK Pathways
- PARP inhibition in cancer therapy
Fujian Medical University
2025
Renmin Hospital of Wuhan University
2015-2024
Wuhan University
2015-2024
Binzhou University
2024
Binzhou Medical University
2024
Zhengzhou People's Hospital
2020
Shandong University
2020
Hubei Cancer Hospital
2019
Beijing Shijitan Hospital
2014
Capital Medical University
2014
Abstract Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. The unregulated expression of Claudin-4 (CLDN4) plays an important role in tumor progression. However, biological CLDN4 GBM still unknown. This study aimed to determine whether mediates glioma progression, if so, it would further explore molecular mechanisms carcinogenesis. Our results revealed that was significantly upregulated specimens cells. inhibition CLND4 could inhibit mesenchymal...
Glioblastoma (GBM) is the most common and fatal primary tumor in central nervous system (CNS). Due to existence of blood-brain barrier (BBB), therapeutics cannot efficiently reach tumors brain, as a result, they are unable be used for effective GBM treatment. Accumulating evidence shows that delivery form nanoparticles (NPs) may allow crossing BBB
Abstract Background Glioblastoma (GBM) is the most common primary malignant tumor in central nervous system. Paclitaxel (PTX) a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, application of PTX GBM hindered by several limitations, including poor water solubility, restricted entry across blood–brain barrier (BBB), enhanced excretion efflux transporters. P‐glycoprotein (P‐gp) crucial transporter that abundantly present cerebral vascular endothelial...
Accumulating evidence suggests that iron-associated proteins contribute to tumor initiation and development. Ferritin light chain (FTL), a key protein in iron metabolism, is associated with the survival of glioblastoma multiforme (GBM) patients; however, molecular mechanisms underlying this association remain largely unclear. Therefore, present study, we investigated role FTL pathogenesis GBM. By using quantitative real-time RT-PCR, found expression was higher patients GBM than those...
Abstract Background Ferroptosis plays a key role in human cancer, but its function and mechanism glioma is not clear. P62/SQSTM1 was reported to inhibit ferroptosis via the activation of NRF2 signaling pathway. In this study we reveal dual p62 glioblastoma (GBM) according p53 status. Method Lipid peroxidation analysis, transmission electron microscopy (TEM), GSH assay were performed determine level ferroptosis. Western blot qPCR obtained detect expression markers. Construction mutant...
Abstract Aims Circular RNAs have been reported to play key roles in the progression of various cancers, including gliomas. The present study was designed investigate role hsa_circ_0072309 autophagy and temozolomide (TMZ) sensitivity glioblastoma (GBM). Methods effect on TMZ were examined by GFP‐RFP‐LC3, transmission electron microscopy(TEM), flow cytometry, Western blot, immunofluorescence. mechanism regulating p53 signaling pathway analyzed using IP, rescue experiments. Results Low...
Circulating tumor cell (CTC) detection is a promising noninvasive technique that can be used to diagnose cancer, monitor progression, and predict prognosis. In this study, the authors aimed investigate clinical utility of CTCs in management diffuse glioma.
Radiotherapy (RT) continues to encounter significant obstacles such as formidable resistance, potential harm adjacent healthy cells, and restricted effectiveness against tumors, resulting in a notable recurrence rate. Therefore, combining imaging, other treatments, suitable enzyme activity one nanoplatform can enhance the RT effect reduce damage normal tissue. In this study, integrating hafnium Prussian blue (PB) nanoparticles (PB NPs) provided innovative hafnium-doped PB (HPB) NPs...
Rho family guanosine triphosphatase (GTPase) 3 (Rnd3), a member of the small GTPase family, is involved in regulation cell actin cytoskeleton dynamics, migration, and proliferation through kinase-dependent signaling pathway. We report role Rnd3 pathogenesis hydrocephalus disorder. Mice with genetic deletion developed severe obstructive enlargement lateral third ventricles, but not fourth ventricles. The cerebral aqueducts Rnd3-null mice were partially or completely blocked by overgrowth...
Glioblastoma multiforme, the most prevalent and aggressive brain tumour, has a poor prognosis. The molecular mechanisms underlying gliomagenesis remain poorly understood. Therefore, research, including various markers, is necessary to understand occurrence development of glioma. Weighted gene co-expression network analysis (WGCNA) was performed construct in TCGA glioblastoma samples. Gene ontology (GO) pathway-enrichment were used identify significance modules. Cox proportional hazards...
Activation of Snail1 signaling promotes the migration and invasion multiple tumors, including glioblastoma multiforme (GBM). However, molecular mechanism that augments during GBM cell remains largely unknown. Identification factors regulate is critical to block tumor invasion. By screening human specimens, we found expression levels small GTPase RND3 positively correlated with E-cadherin claudin, biomarkers negatively regulated by Snail1. Downregulation claudin has been associated cells. We...
Ferroptosis is an iron dependent cell death closely associated with p53 signaling pathway and aberrantly regulated in glioblastoma (GBM), yet the underlying mechanism needs more exploration. Identifying new factors which regulate ferroptosis GBM essential for treatment.Glioma growth was evaluated by viability assays colony formation assays. Lipid reactive oxygen species (ROS) assays, lipid peroxidation glutathione transmission electron microscopy were used to assess degree of cellular GBM....
The Fc Fragment of IgG Binding Protein (FCGBP) has been proven to participate in intestinal tumor immunity. However, the biological role FCGBP remained unclear glioma. differential expression was explored by Oncomine and GEPIA databases. effect on prognosis analyzed via Kaplan–Meier plotter GEPIA. Tumor Immune Estimation Resource (TIMER) tool used determine correlations with immune infiltration. Firstly, highly expressed glioma correlated a worse prognosis. Gene Ontology (GO) KEGG pathway...
The aim of this study was to analyse 19 recurrent keratocystic odontogenic tumours (KCOTs).19 patients with KCOTs were retrospectively analysed. These had been treated by either enucleation or a combination and Carnoy's solution. analyses covered major aspects primary KCOT and/or identities, including patient profile, clinical features, histopathology, radiology, treatment prognosis.19 (7.4%) out 257 cases recurred, an average age 30.5 years (age range 18-45 years). 15 lesions in the...
PURPOSE: To investigate the anticancer activity of ellagic acid (EA) in U251 human glioblastoma cells and its possible molecular mechanism. METHODS: The were treated with EA at various concentrations for different time periods. Cell viability cell proliferation detected by counting kit-8(CCK-8) assay live/dead respectively. apoptosis measured Annexin V-FITC/PI double staining method flow cytometry Mitochondrial membrane potential separately. cycle was PI cytometry. expressions Bcl-2,...
Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis particularly complicated. Among many possible mechanisms underlying pathogenesis, hyperactivation PI3K/Akt pathway essential to occurrence development glioma through loss PTEN or somatic activating mutations PIK3CA. In present study, we investigated effect PI3Kβ inhibitor AZD6482 on cells. The CCK-8 assay showed dose-dependent cytotoxicity cell lines treated with AZD6482. Additionally, treatment was...