A5021339843- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Cognitive Functions and Memory
- Cognitive Abilities and Testing
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Crystallization and Solubility Studies
- Bone and Joint Diseases
- Tryptophan and brain disorders
- Urinary Bladder and Prostate Research
- Natural product bioactivities and synthesis
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Chromatography
- Cardiovascular Health and Risk Factors
- Luminescence and Fluorescent Materials
- Neurological Disease Mechanisms and Treatments
Institute of Psychology, Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2016-2025
BeiGene (China)
2025
Wenzhou Medical University
2022-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Civil Aviation University of China
2024
Wuhan University of Technology
2016-2024
Ningbo University
2022-2024
Shandong University
2024
Czech Academy of Sciences, Institute of Psychology
2019-2024
ABSTRACT Background: We examine the association between leisure-time activities and risk of developing cognitive impairment among Chinese older people, further investigate whether varies by educational level. Methods: This follow-up study included 6,586 participants (aged 79.5 ± 9.8 years, range 65–105 51.7% female) Longitudinal Healthy Longevity Survey who were aged ≥65 years free in 2002. Incident was defined at 2005 or 2008/2009 survey following an education-based cut-off on adapted...
Abstract Inhibitory control (including response inhibition and interference control) develops rapidly during the preschool period is important for early cognitive development. This study aimed to determine training transfer effects on in young children. Children group (N = 20; 12 boys, mean age 4.87 ± 0.26 years) played “Fruit Ninja” a tablet computer 15 min/day, 4 days/week, 3 weeks. active 10 4.88 0.20 coloring game 1–2 Several tasks (involving inhibitory control, working memory fluid...
The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. disconnection between them is suggested be an important cause cognitive decline in normal Here, using multimodal intervention training, we investigated functional plasticity resting-state connectivity these two regions older adults. intervention, comprised Tai Chi exercise, group counseling, was conducted explore regional changes default-mode network, as well prefrontal-based voxel-wise whole...
Social support shows a protective effect against cognitive impairment in older adults. However, the longitudinal relationship between distinct sources of social and incidence remains unclear. This study aims to investigate association different among adults China.We used data (2005-2014) from Chinese Longitudinal Healthy Longevity Survey (CLHLS, 2005-2014, mean follow-up years 5.32 ± 2.64). In total, 5897 participants (aged 81.7 9.7 years, range 65-112 49.0% male) were enrolled. Cognitive...
Abstract Background Glioblastoma (GBM) is the most common primary malignant tumor in central nervous system. Paclitaxel (PTX) a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, application of PTX GBM hindered by several limitations, including poor water solubility, restricted entry across blood–brain barrier (BBB), enhanced excretion efflux transporters. P‐glycoprotein (P‐gp) crucial transporter that abundantly present cerebral vascular endothelial...
Mounting evidence suggests that enriched mental, physical, and socially stimulating activities are beneficial for counteracting age-related decreases in brain function cognition older adults. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate the plasticity of activity response a combined cognitive-psychological-physical intervention investigated contribution intervention-related changes individual performance healthy The was composed 6-week program including cognitive...
To investigate whether loneliness and social isolation could independently predict subsequent risk of cognitive impairment in Chinese oldest old, to examine possible gender differences.The sample included 2,732 older adults aged 80 years above with intact function from the Longitudinal Healthy Longevity Survey 2002-2018 waves, an average follow-up 4.24 years. Loneliness was measured by a single-item question about how often participant felt lonely. Social defined marital status, frequent...
Abstract The aim of the present study was to compare relations between subtypes social withdrawal and socio‐emotional adjustment in Chinese children early adolescents. Participants included 571 ( M age = 9.62 years) 345 adolescents 12.12 mainland China. Social (i.e., shyness, unsociability, avoidance) indices were assessed via self‐reports, peer nominations, teacher ratings. Shyness tended be more strongly associated with emotional maladjustment adolescence, whereas unsociability...
Circulating tumor cell (CTC) detection is a promising noninvasive technique that can be used to diagnose cancer, monitor progression, and predict prognosis. In this study, the authors aimed investigate clinical utility of CTCs in management diffuse glioma.
Loneliness is considered a risk factor for cardiovascular diseases (CVD), but related evidence mixed. Examining trajectories of loneliness over time, as compared to the assessment at single time point, can be useful better understand risks CVD. The present study aimed examine and their impacts on CVD in Chinese middle-aged older adults.
Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein (MAP4K) family. It has been reported that HPK1 negatively regulates activation T cells. Several compounds have developed and tested in clinical trials to target for cancer immunotherapy. However, whether inhibition sufficient eliminate immunosuppressive function HPK1, particularly cells, remains elusive. In this study, genetic tools were used edit human lymphocyte cell line Jurkat. The HPK1-null...
Introduction Cardiovascular health is influenced by various factors, including not only physiological and behavioural ones but also psychological well-being. However, when developing comprehensive preventive approaches, interventions often receive less attention, despite their possible multiple mechanisms on cardiovascular health. Incorporating both healthy behaviour well-being promotion would be a more efficacious approach. This study aims to investigate the effects of community-based...
This study examined the effects of a multimodal intervention on spontaneous brain activity in healthy older adults. Seventeen adults received six-week that consisted cognitive training, Tai Chi exercise and group counseling, while 17 control attended health knowledge lectures. The demonstrated enhanced memory social support compared to group. amplitude low frequency fluctuations (ALFF) middle frontal gyrus, superior gyrus anterior cerebellum lobe was for group, showed reduced ALFF these...
As mnemonic utilization deficit in older adults associates with age-related decline executive function, we hypothesized that memory strategy training combined function might induce larger effect and broader effects non-memory outcomes than pure training. The present study compared the of cognitive (executive plus training) to Forty healthy were randomly assigned a group or group. A control receiving no was also included. Combined received 16 sessions (8 followed by 8 training). Memory...
An urban agglomeration is a highly developed spatial area formed by integrated cities. While previous studies have analyzed green space allocation at the provincial and city scales, there insufficient information on in agglomerations. For this research, database of spaces eight agglomerations (133 cities) China from 2002 to 2019 was constructed better understand equity distribution among land resources. A index (GEI) established based Theil combined with GeoDetector analyze differences...
Hippocampal/parahippocampal structural changes accompany major depressive disorders in the elderly, but whether subthreshold depression (StD) at an advanced age is also accompanied by similar hippocampal/parahippocampal volumes still unknown. By using voxel-based morphometry (VBM) analysis of gray matter, we explored there are alterations hippocampus/parahippocampus and correlations between its volume participants' self-reported symptoms. Participants were 19 community-dwelling older adults...