A5101563031- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- Machine Learning in Healthcare
- Metal-Organic Frameworks: Synthesis and Applications
- Supercapacitor Materials and Fabrication
- Health, Environment, Cognitive Aging
- Membrane Separation Technologies
- Nanoplatforms for cancer theranostics
- Membrane Separation and Gas Transport
- Zeolite Catalysis and Synthesis
- Generative Adversarial Networks and Image Synthesis
- Advanced battery technologies research
- Luminescence and Fluorescent Materials
- Optimization and Packing Problems
- Artificial Intelligence in Healthcare and Education
- Ammonia Synthesis and Nitrogen Reduction
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
- Power Systems and Renewable Energy
- Natural Compounds in Disease Treatment
- Soil, Finite Element Methods
Shandong University
2005-2024
Weill Cornell Medicine
2024
Cornell University
2024
Wuhan University
2023-2024
Renmin Hospital of Wuhan University
2023-2024
Nankai University
2023-2024
Dalian University of Technology
2007-2023
Qingdao University
2021-2022
Zunyi Medical University
2022
Tianjin University of Science and Technology
2022
Abstract Accurately distinguishing between enantiomeric molecules is a fundamental challenge in the field of chemistry. However, there still significant room for improvement both selectivity (K R ( S ) /K and binding strength most reported macrocyclic chiral receptors to meet demands practical application scenarios. Herein, we synthesized water‐soluble conjugated tubular host—namely, corral[4]BINOL—using 1,1′‐bi‐2‐naphthol (BINOL) derivative as repeating unit. The backbone endows...
The precise recognition and sensing of steroids, a type vital biomolecules, hold immense practical value across various domains. In this study, we introduced corral[4]BINOLs (C[4]BINOLs), pair enantiomeric conjugated deep-cavity hosts, as novel synthetic receptors for binding steroids. Due to the strong hydrophobic effect their deep nonpolar, chiral cavities, two enantiomers C[4]BINOLs demonstrated exceptionally high affinities (up 10
Abstract Background Glioblastoma (GBM) is the most common primary malignant tumor in central nervous system. Paclitaxel (PTX) a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, application of PTX GBM hindered by several limitations, including poor water solubility, restricted entry across blood–brain barrier (BBB), enhanced excretion efflux transporters. P‐glycoprotein (P‐gp) crucial transporter that abundantly present cerebral vascular endothelial...
The development of artificial receptors that combine ultrahigh-affinity binding and controllable release for active guests holds significant importance in biomedical applications. On one hand, a complex with an exceedingly high affinity can resist unwanted dissociation induced by dilution effect interferents within physiological environments. the other stimulus-responsive guest is essential precisely activating its function. In this context, we expanded hydrophobic cavity surface...
For prevention of the coronavirus disease 2019 caused by novel SARS-CoV-2, an effective vaccine is critical. Herein, several potential peptide epitopes from spike protein SARS-CoV-2 have been synthesized and covalently linked with cross-reactive material (CRM197). Immunization mice resulting conjugates induced high titers IgG antibodies against protein. Importantly, post-immune sera effectively neutralized pseudovirus, suggesting identified are protective, these promising leads for...
Abstract The development of artificial receptors that combine ultrahigh‐affinity binding and controllable release for active guests holds significant importance in biomedical applications. On one hand, a complex with an exceedingly high affinity can resist unwanted dissociation induced by dilution effect interferents within physiological environments. the other stimulus‐responsive guest is essential precisely activating its function. In this context, we expanded hydrophobic cavity surface...
Abstract Cytotoxic T‐lymphocytes (CTLs) are central for eliciting protective immunity against malignancies and infectious diseases. Here, the first time, partially oxidized acetalated dextran nanoparticles (Ox‐AcDEX NPs) with an average diameter of 100 nm fabricated as a general platform vaccine delivery. To develop effective anticancer vaccines, Ox‐AcDEX NPs conjugated representative CTL peptide epitope (CTLp) from human mucin‐1 (MUC1) sequence TSAPDTRPAP (referred to Mp1) immune‐enhancing...
Subarachnoid hemorrhage (SAH) is a life-threatening acute hemorrhagic cerebrovascular disease, with early brain injury (EBI) being the main cause of high mortality and severe neurological dysfunction. Oxidative stress plays crucial role in pathogenesis EBI. In this study, we synthesized antioxidant nanoparticles based on self-assembled oleanolic acid (OA) using solvent volatilization method. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron...
SUMMARY The natural site of infection for T. gondii is the mucosal surface intestine, so protective immunity obtained after with points to importance developing a vaccine that stimulates defences. In this study, an aroA − and aroD attenuated strain Salmonella typhimurium (BRD509) has been used deliver recombinant eukaryotic plasmid pSAG 1‐2 /CTA 2 /B expressing multi‐antigenic gene encoding SAG1 SAG2 linked A subunits cholera toxin as candidate oral vaccine. Immunoblot analysis showed...
Major diseases, such as cancer and COVID-19, are frightening global health problems, sustained action is necessary to develop vaccines. Here, for the first time, ethoxy acetalated dextran nanoparticles (Ace-Dex-NPs) functionalized with 9-N-(4H-thieno[3,2-c]chromene-2-carbamoyl)-Siaα2-3Galβ1-4GlcNAc (
Glioma is the most common primary tumor in human central nervous system. This study was designed to explore expression of BZW1 glioma and its relevance clinicopathological features outcome patients. transcription profiling data were obtained from The Cancer Genome Atlas (TCGA). TIMER2, GEPIA2, GeneMANIA, Metascape searched present study. Cell animal experiments conducted verify effect on cell migration vitro vivo. Transwell assays, western blotting immunofluorescence assays performed. We...
Abstract Accurately distinguishing between enantiomeric molecules is a fundamental challenge in the field of chemistry. However, there still significant room for improvement both selectivity (K R ( S ) /K and binding strength most reported macrocyclic chiral receptors to meet demands practical application scenarios. Herein, we synthesized water‐soluble conjugated tubular host—namely, corral[4]BINOL—using 1,1′‐bi‐2‐naphthol (BINOL) derivative as repeating unit. The backbone endows...
When multiple inverters are connected to the grid, due uncertainty of internal model and presence external disturbances, grid-connected current waveform will deviate from expectation. In this paper, Active Disturbance Rejection Control (ADRC) strategy is presented suppress perturbations, moreover, first-order ADRC parameters designed. Finally, MATLAB/Simulink utilized verify control ADRC. The simulation results demonstrate that method can disturbance effectively.
As a novel class of VLP vaccine carrier, the bacteriophage MX1 virus-like particle (VLP) is used for first time to construct MX1-NHAcGD2 and MX1-NHAcGD3 conjugates. These conjugates can be exciting leads anticancer vaccines.