A5071780343- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Meningioma and schwannoma management
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Medicinal Plant Pharmacodynamics Research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- TGF-β signaling in diseases
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Circular RNAs in diseases
Wuhan University
2014-2024
Renmin Hospital of Wuhan University
2014-2024
Yale University
2016
Nanfang Hospital
2015
Southern Medical University
2015
IHI Corporation (United States)
2011
The blood–brain barrier (BBB) is partially disrupted in brain tumors. Despite the gaps BBB, there an inadequate amount of pharmacological agents delivered into brain. Thus, low delivery efficiency renders many these ineffective treating cancer. In this report, we proposed "autocatalytic" approach for increasing transport nanoparticles strategy, a small number enter via transcytosis or through BBB gaps. After penetrating release modulators, which enables more to be transported, creating...
Abstract Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. The unregulated expression of Claudin-4 (CLDN4) plays an important role in tumor progression. However, biological CLDN4 GBM still unknown. This study aimed to determine whether mediates glioma progression, if so, it would further explore molecular mechanisms carcinogenesis. Our results revealed that was significantly upregulated specimens cells. inhibition CLND4 could inhibit mesenchymal...
Glioblastoma (GBM) is the most common and fatal primary tumor in central nervous system (CNS). Due to existence of blood-brain barrier (BBB), therapeutics cannot efficiently reach tumors brain, as a result, they are unable be used for effective GBM treatment. Accumulating evidence shows that delivery form nanoparticles (NPs) may allow crossing BBB
Abstract Background Glioblastoma (GBM) is the most common primary malignant tumor in central nervous system. Paclitaxel (PTX) a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, application of PTX GBM hindered by several limitations, including poor water solubility, restricted entry across blood–brain barrier (BBB), enhanced excretion efflux transporters. P‐glycoprotein (P‐gp) crucial transporter that abundantly present cerebral vascular endothelial...
Activation of Snail1 signaling promotes the migration and invasion multiple tumors, including glioblastoma multiforme (GBM). However, molecular mechanism that augments during GBM cell remains largely unknown. Identification factors regulate is critical to block tumor invasion. By screening human specimens, we found expression levels small GTPase RND3 positively correlated with E-cadherin claudin, biomarkers negatively regulated by Snail1. Downregulation claudin has been associated cells. We...
The Fc Fragment of IgG Binding Protein (FCGBP) has been proven to participate in intestinal tumor immunity. However, the biological role FCGBP remained unclear glioma. differential expression was explored by Oncomine and GEPIA databases. effect on prognosis analyzed via Kaplan–Meier plotter GEPIA. Tumor Immune Estimation Resource (TIMER) tool used determine correlations with immune infiltration. Firstly, highly expressed glioma correlated a worse prognosis. Gene Ontology (GO) KEGG pathway...
Abstract Background Mitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase ROS content is primary cause oxidative stress, which plays an important role tumor proliferation, invasion, angiogenesis, treatment. However, relationship between mitochondrial stress-related genes glioblastoma (GBM) remains unclear. This study aimed to investigate value mitochondria prognosis therapeutic targets GBM. Methods We retrieved from several public databases....
MS4A6A has been recognized as being associated with aging and the onset of neurodegenerative disease. However, mechanisms in glioma biology prognosis are ill-defined. Here, we show that is upregulated tissues, resulting unfavorable clinical outcomes poor responses to adjuvant chemotherapy. Multivariate Cox regression analysis suggested expression can act a strong independent predictor for (CGGA1: HR: 1.765, p < 0.001; CGGA2: 2.626, TCGA: 1.415, Rembrandt: 1.809, Gravendeel: 1.613,...
As an important part of tumor immunotherapy for adjunct, therapeutic vaccines have been effective against multiple solid cancers, while their efficacy lower grade glioma (LGG) remains undefined. Immunophenotyping tumors is essential tool to evaluate the immune function patients with immunodeficiency or autoimmunity. Therefore, this study aims find potential antigen LGG and identify suitable population cancer vaccination based on landscape.The genomic clinical data 529 were obtained from...
To explore the role and possible regulatory mechanisms of CYP2E1 in gliomas.RNA-seq data corresponding clinical information glioma patients were collected from The Cancer Genome Atlas Chinese Glioma Atlas, mRNA normal brain tissues obtained by Genotype-Tissue Expression project. Wilcoxon test was performed to analyze correlation between expression subtypes. Univariate multivariate Cox proportional hazards regression, receiver operating characteristic curves, Kaplan-Meier plots used evaluate...
Background: Clinical benefits from standard therapies against glioblastoma (GBM) are limited in part due to the intrinsic radio- and chemo-resistance. As an essential of tumor immunotherapy for adjunct, therapeutic vaccines have been effective multiple solid cancers, while their efficacy GBM remains undefined. Therefore, this study aims find possible antigens identify suitable population cancer vaccination through immunophenotyping. Method: The genomic responding clinical data 169 samples...
Abstract Activation of Notch signaling contributes to glioblastoma multiform ( GBM ) tumorigenesis. However, the molecular mechanism that promotes augmentation during genesis remains largely unknown. Identification new factors regulate is critical for tumor treatment. The expression levels RND 3 and its clinical implication were analyzed in patients. as a novel factor was demonstrated vitro by cell experiments vivo xenograft model. We found significantly decreased human glioblastoma....
Gliomas are the most common intracranial tumors and classified as I-IV. Among them, glioblastoma multiforme (GBM) is invasive glioma with a poor prognosis. New molecular biomarkers that can predict clinical outcomes in GBM patients must be identified, which will help comprehend their pathogenesis supply personalized treatment. Our research revealed four powerful survival indicators by reanalyzing microarray data genetic sequencing public databases. Moreover, it unraveled new potential...
Purpose: Cancer stem cells have recently been thought to be closely related tumor development and reoccurrence.It may a promising way cure malignant glioma by using cell-targeted dendritic as vaccine.In this study, we explored whether pulsing with antigens of was potent induce specific cytotoxic T lymphocytes anti-tumor immunity.Materials Methods: were cultured from cell line U251.Lysate obtained the repeated freezing thawing method.Dendritic (DCs) induced murine bone marrow cells,...
Gliomas are one of the most frequent types nervous system tumours and have significant morbidity mortality rates. As a result, it is critical to fully comprehend molecular mechanism glioma predict prognosis target gene therapy. The goal this research was discover hub genes investigate their prognostic diagnostic usefulness. In study, we collected mRNA expression profiles clinical information from patients in TCGA, GTEx, GSE68848, GSE4920 databases. WGCNA differential analysis identified 170...