A5027469029- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- TGF-β signaling in diseases
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibroblast Growth Factor Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Medicinal Plant Pharmacodynamics Research
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Spinal Cord Injury Research
- Acupuncture Treatment Research Studies
Renmin Hospital of Wuhan University
2011-2024
Wuhan University
2012-2024
Nanjing University of Posts and Telecommunications
2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2020-2023
First Hospital of Jiaxing
2016
The cerebral ischemia injury can result in neuronal death and/or functional impairment, which leads to further damage and dysfunction after recovery of blood supply. Cerebral ischemia/reperfusion (CIRI) often causes irreversible brain death, involves many complex pathological processes including oxidative stress, amino acid toxicity, the release endogenous substances, inflammation apoptosis. Oxidative stress are interactive play critical roles brain. is important process ischemic stroke for...
PURPOSE A retrospective study of the results neoplastic cord compression was undertaken to determine effectiveness surgical treatment and assess quality life in patients undergoing extensive procedures with potential morbidity. PATIENTS AND METHODS Over a 5-year period (1989 1993), total 110 underwent surgery. Fifty-five (50%) had undergone prior treatment, including 47 (43%) who failed respond irradiation (RT). Before surgery, 48 (44%) were nonambulatory, severe paresis being present 20....
Accumulating evidence suggests that iron-associated proteins contribute to tumor initiation and development. Ferritin light chain (FTL), a key protein in iron metabolism, is associated with the survival of glioblastoma multiforme (GBM) patients; however, molecular mechanisms underlying this association remain largely unclear. Therefore, present study, we investigated role FTL pathogenesis GBM. By using quantitative real-time RT-PCR, found expression was higher patients GBM than those...
Bladder cancer is one of the causes cancer‑related death and has a high mortality rate. Daidzein, natural isoflavone compound predominantly extracted from soybeans, been reported to exhibit several bioactivities, including anti-tumor. However, effects daidzein on bladder remains unrevealed. Here we investigated molecular mechanisms using multiple in vitro cell lines vivo xenograft mice studies. Our results showed that reduced viability time- concentration‑dependent manner. Daidzein...
Activation of Snail1 signaling promotes the migration and invasion multiple tumors, including glioblastoma multiforme (GBM). However, molecular mechanism that augments during GBM cell remains largely unknown. Identification factors regulate is critical to block tumor invasion. By screening human specimens, we found expression levels small GTPase RND3 positively correlated with E-cadherin claudin, biomarkers negatively regulated by Snail1. Downregulation claudin has been associated cells. We...
Stroke is a leading cause of death and disability, while its pathophysiological mechanisms are not fully understood. In this study, we used the tMCAO mice model to investigate role circCCDC9 in pathogenesis stroke. We found that expression was significantly decreased brains mice. The Evens blue brain water content were higher Pre-IR Pre-IR+Vector mice, these patterns partially reversed by overexpression circCCDC9. nitrite eNOS groups, which restored overexpression. Overexpression also...
Abstract Activation of Notch signaling contributes to glioblastoma multiform ( GBM ) tumorigenesis. However, the molecular mechanism that promotes augmentation during genesis remains largely unknown. Identification new factors regulate is critical for tumor treatment. The expression levels RND 3 and its clinical implication were analyzed in patients. as a novel factor was demonstrated vitro by cell experiments vivo xenograft model. We found significantly decreased human glioblastoma....
Abstract Malignant glioma remains the most frequent form of primary brain tumors all over world. The gliomagenesis is characterized by various molecular processes such as neoplastic transformation, dysregulation cell cycle, and angiogenesis. Among these biomolecular events, existence inflammation oxidative stress pathways in development has been reported. PTPN2 associated with several inflammatory disorders. However, biological role responses involved poorly known. Here, we focused on its...
Gliomas are the most common intracranial tumors and classified as I-IV. Among them, glioblastoma multiforme (GBM) is invasive glioma with a poor prognosis. New molecular biomarkers that can predict clinical outcomes in GBM patients must be identified, which will help comprehend their pathogenesis supply personalized treatment. Our research revealed four powerful survival indicators by reanalyzing microarray data genetic sequencing public databases. Moreover, it unraveled new potential...
Purpose: Cancer stem cells have recently been thought to be closely related tumor development and reoccurrence.It may a promising way cure malignant glioma by using cell-targeted dendritic as vaccine.In this study, we explored whether pulsing with antigens of was potent induce specific cytotoxic T lymphocytes anti-tumor immunity.Materials Methods: were cultured from cell line U251.Lysate obtained the repeated freezing thawing method.Dendritic (DCs) induced murine bone marrow cells,...
Foodborne pathogens are harmful to human health because they can contaminate food and induce diseases. To efficiently distinguish determine foodborne bacteria, an ultrasensitive point-of-care electrochemical biosensor was designed for 16S rRNA detection by coupling a signal amplification strategy with MoS2-based nanoprobes. Gold nanoparticles thionine co-functionalized molybdenum disulfide (MoS2) nanocomposites (MoS2-Thi-AuNPs) were used construct nanoprobes, which monitor the process...
Patients with cirrhosis are known to develop small bowel mucosal lesions. However, the occurrence of lesions in patients abnormal liver function test results absence chronic disease has not been fully evaluated. This study aims examine association between endoscopic and dysfunction without confirmed disease.Two hundred ninety six consecutive who met selection criteria underwent capsule endoscopy. The severity intestinal was evaluated quantitatively using Lewis scoring system, hepatic an...
Abstract Studies have shown that the inhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN)was neuroprotective against ischemia/reperfusion(I/R) injury. Bisperoxovanadium (bpV), a derivative vanadate, is well-established inhibitor PTEN. However, its function islimited due to general inadequacy in penetrating cell membranes. Mxene(Ti 3 C 2 T x ) novel two-dimensional lamellar nanomaterial with an excellent ability penetrate membrane. Yet, effects this nervous system...