A5101599308- Opioid Use Disorder Treatment
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Reproductive Biology and Fertility
- Prenatal Substance Exposure Effects
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Substance Abuse Treatment and Outcomes
- Cancer survivorship and care
- Effects of Vibration on Health
- Balance, Gait, and Falls Prevention
- Sexual Differentiation and Disorders
- Amoebic Infections and Treatments
- Economic and Financial Impacts of Cancer
- Neurogenetic and Muscular Disorders Research
- Circular RNAs in diseases
- Pain Management and Opioid Use
- Fibroblast Growth Factor Research
- Nephrotoxicity and Medicinal Plants
Shanghai University of Medicine and Health Sciences
2025
People's Hospital of Yangzhong
2024
Cancer Genetics (United States)
2024
Columbia University
2024
Shanghai Tenth People's Hospital
2023
Tongji University
2023
Indivior (United States)
2023
Tongren Hospital
2014-2022
Shanghai Jiao Tong University
2019-2022
Oregon Health & Science University
2018-2021
Resistance to cisplatin (DDP) remains a major obstacle in the control of gastric cancer (GC) progression. A previous study revealed that microRNA-21 (miR-21) contributes DDP resistance GC cells via phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. The aim current was explore mechanisms underlying cytoprotective function miR-21. In this study, DDP-resistant were obtained by continuous exposure human adenocarcinoma increasing concentrations DDP. Western blot analysis used...
Sarcopenia is a syndrome commonly found in older people. The aim of this study was to evaluate the effects whole-body vibration training (WBVT) and resistance (RT) on body composition, muscle strength, physical performance blood biomarkers people with sarcopenia. We conducted 12-week, 3-times-weekly assessor-blinded, randomized controlled trial 27 sarcopenia aged ≥ 65 years. Subjects were into WBVT group (n = 14) RT 13). primary outcome knee extension strength (KES). Secondary outcomes...
Bladder cancer is one of the causes cancer‑related death and has a high mortality rate. Daidzein, natural isoflavone compound predominantly extracted from soybeans, been reported to exhibit several bioactivities, including anti-tumor. However, effects daidzein on bladder remains unrevealed. Here we investigated molecular mechanisms using multiple in vitro cell lines vivo xenograft mice studies. Our results showed that reduced viability time- concentration‑dependent manner. Daidzein...
Colorectal cancer (CRC) can be effectively prevented or detected with guideline concordant screening, yet Medicaid enrollees experience disparities. We used microsimulation to project CRC screening patterns, cases averted, and life-years gained in the population of 68,077 Oregon 50-64 over a five year period starting January 2019. The simulation estimated cost-effectiveness intervention scenarios - academic detailing plus provider audit feedback (Detailing+), patient reminders (Reminders),...
Abstract Acquired resistance to PARP inhibitors (PARPi) remains a treatment challenge for BRCA 1/2-mutant breast cancer that drastically shortens patient survival. Although several mechanisms have been identified, none successfully targeted in the clinic. Using new PARPi-resistance models of Brca1 - and Bard1 -mutant generated in-vivo, we identified FLT1 (VEGFR1) as driver resistance. Unlike known role VEGF signaling angiogenesis, demonstrate novel, non-canonical protects cells from PARPi...
Objective The aim of this study was to assess the impact short-term, hospital-based, supervised multimodal prehabilitation on elderly patients with colorectal cancer. Methods A single-center, retrospective conducted from October 2020 December 2021, which included a total 587 CRC who were scheduled undergo radical resection. propensity score-matching analysis performed reduce selection bias. All treated within standardized enhanced recovery pathway, and in group received an additional...
The study examined the association of Affordable Care Act's 2014 Medicaid expansion on use psychosocial services and pharmacotherapies for opioid disorders among Oregon recipients. Logistic regression analysis utilization care before (January 1, 2010–December 31, 2013) after in 2014–December 2016). Adult membership Health Plan (Medicaid) increased 180% following (2013 = 172,539; 482,081) number with a diagnosis OUD nearly doubled 6808; 13,418). More individuals received 4714; 8781)...
Breast cancer (BC) is the most common affecting women and leading cause of cancer-related deaths worldwide. Compelling evidence indicates that microRNAs (miRNAs) are inextricably involved in development cancer. Here, we constructed a novel model, based on miRNA-seq clinical data downloaded from The Cancer Genome Atlas (TCGA). Data total 962 patients were included this study, relationships among their clinicopathological features, survival, expression levels analyzed. Hsa-miR-186 hsa-miR-361...
This study aimed to identify stromal molecular signatures associated with breast and prostate cancer. The microarray data GSE26910 was downloaded from Gene Expression Omnibus database, including six invasive tumor stroma, matched normal controls, controls. differentially expressed genes (DEGs) in tumors stroma were, respectively, identified. Then common (B_P.DEGs) were further screened. Protein–protein interaction (PPI) network constructed Ontology analysis performed. Besides, gene–chemical...
It is important to understand patterns and predictors of initiation engagement in treatment for Medicaid-covered individuals with substance use disorders because Medicaid a major source payment addiction the United States. Our analysis examined similarities differences between adults adolescents.
Congenital heart disease (CHD) is the most common birth abnormality, but etiology of CHD unknown.ISL1 may play a fundamental role in cardiac morphogenesis, and mutations this gene could cause CHD.To evaluate whether genetic variations ISL1 are associated with Chinese Han people, polymerase chain reaction restriction fragment-length polymorphism SNaPshot were used to examine 9 polymorphisms 233 patients ©FUNPEC-RP www.funpecrp.com.
SUMMARY Chromosomal abnormalities are common in human embryos. Previous studies have suggested links between centrosome number and chromosome abnormalities, but information regarding embryos is limited. We analyzed embryonic stem cells (hESCs). Following normal fertilization, supernumerary centrosomes were present at rates of 7.3% two‐pronucleus (2PN)‐stage zygotes 6.5% first‐cleavage zygotes. Supernumerary also detected 24.4% blastomeres from 60% derived 2PN Conversely, mono‐ (1PN)...
Objectives: The objective of this study is to identify demographic and clinical characteristics patients with a pain diagnosis who fill potentially inappropriate opioid prescriptions within the Oregon Medicaid population. Methods: Using de-identified claims data (2010–2014), series logistic regression models was estimated factors associated receipt potential among acute or chronic pain. Analyses included total 204,364 records, representing 118,671 unique patients. Results: percentage filling...
Breast cancer (BC) is the most common affecting women and leading cause of cancer-related deaths worldwide. Compelling evidence indicates that pyroptosis inextricably involved in development may activate tumor-specific immunity and/or enhance effectiveness existing therapies. We constructed a novel prognostic prediction model for BC, based on pyroptosis-related clusters, according to RNA-seq clinical data downloaded from TCGA. The proportions tumor-infiltrating immune cells differed...
BACKGROUND Current surgical procedures for anorectal abscesses, including incision and drainage alone or combined concurrent fistulotomy, remain controversial primarily due to the unpredictability of postoperative recurrence progression anal fistula. AIM To evaluate factors that predict abscesses propose a new classification guide procedures. METHODS In this retrospective study, 525 patients with treated by alone, at tertiary general hospital from August 2012 July 2022, were included. A...
This study aimed at exploring the genes that may be related to prognosis of primary breast cancer (BC) patients. The gene expression microarray data, together with sample survival data were acquired from Cancer Genome Atlas database. top 20% according value variance subjected hierarchical cluster analysis. Bootstrap methods utilized assess stability cluster. Cox regression was applied screen time patients BC, and Beta-Uniform Mixture model adjust significance numerous tests. Further,...