A5100343001- Pregnancy and preeclampsia studies
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Advanced Glycation End Products research
- Oral microbiology and periodontitis research
- Advanced biosensing and bioanalysis techniques
- Mesenchymal stem cell research
- Bioinformatics and Genomic Networks
- Tannin, Tannase and Anticancer Activities
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Immune Response and Inflammation
- RNA modifications and cancer
- Gestational Diabetes Research and Management
- Helicobacter pylori-related gastroenterology studies
- Respiratory viral infections research
- Industrial Technology and Control Systems
First People's Hospital of Chongqing
2024
Jiangnan University
2024
Ningxia Medical University
2023-2024
Yebio Bioengineering (China)
2024
China Three Gorges University
2024
Instituto de Ciencias Agrarias
2023
Mahasarakham University
2023
Shandong Agricultural University
2018-2022
Chinese PLA General Hospital
2021-2022
Hong Kong Polytechnic University
2022
The Dorsal morphogen acts as both an activator and a repressor of transcription in the Drosophila embryo to regulate expression dorsal/ventral patterning genes. Circumstantial evidence has suggested that is intrinsic additional factors (corepressors) convert it into repressor. These corepressors, however, have previously eluded definitive identification. We show here, via analysis embryos lacking maternally encoded Groucho corepressor protein-binding assays, recruitment template by...
ABSTRACTDorsal functions as both an activator and repressor of transcription to determine dorsoventral fate in the Drosophila melanogaster embryo. Repression by Dorsal requires corepressor Groucho (Gro) is mediated silencers termed ventral repression regions (VRRs). A VRR zerknüllt(zen) contains binding sites well essential element AT2. We have identified purified AT2 DNA activity embryos shown it consist cut(ct) dead ringer (dri) gene products. Studies loss-of-function mutations ct dri...
Spontaneous combustion of residual coal in the goaf is one main disasters mines. Understanding law spontaneous can effectively prevent mine fires. This paper establishes a dynamic evolution model overburden caving and porosity using PFC numerical simulation software, compares analyzes changes zone at advancing distances 50m, 70m, 100m. The results show that when working face advances 100m, decreases from 0-0.6 to 0.16-0.3. range on return air side expands 42m-50m 39m-61m, inlet side, it 0...
Preeclampsia (PE) is a complication during pregnancy that diagnosed by new onset of hypertension and proteinuria. Although the pathogenesis PE not fully understood, growing body evidence indicates oxidative stress mitochondrial dysfunction might contribute to progression PE. Therefore, aim present study was determine role mitophagy in PE, evaluate DNA damage‑regulated autophagy modulator 1 (DRAM1) development First, mouse model induced hypoxia‑inducible factor 1α established, high levels...
Pachymic acid (PA) is derived from Poria cocos. PA has a variety of pharmacological and inhibitory effects on various tumors. However, the mechanism action in gastric cancer (GC) remains unclear.
—In order to calculate the noise field distribution in main transformer room of an indoor substation accurately, a thermal-acoustic coupling idea was introduced, and solving algorithm based on proposed view quality loss caused by effect ambient temperature changes. Firstly, fluid-structure model is established, computational fluid dynamics method used flow boundary conditions under action heat source; Then, extracting rheological equation environmental calculation, use difference function...
Histone deacetylases (HDACs) are important in chromatin remodeling and epigenetic regulation of gene expression. deacetylase inhibitors (HDACi) have highly effective anti-metastatic anti-angiogenic activity various types cancer, while the molecular mechanisms involved this process not fully understood. In present study, trichostatin A (TSA), a HDACi, was found to suppress MCF-7 breast carcinoma cell invasion upregulate TET1 expression dose-dependent manner. TET1, dioxygenase cytosine...
Asthma is a prevalent chronic inflammatory airway disease that characterised by remodelling and hyperresponsiveness. Abnormal proliferation migration of smooth muscle cells (ASMCs) contribute to in asthma. However, the molecular mechanism underlying an increased ASMC mass asthma remains elusive. Herein, we aimed at investigating regulation lncRNA PVT1 on ASMCs focussing migration.Expression levels miR-590-5p serum collected from 24 children with 10 control were determined qRT-PCR. prior post...
Background: Observational studies that have supported the role of leptin level in schizophrenia (SCZ) risk are conflicting. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to investigate whether circulating and soluble plasma receptor (sOB-R) levels play causal SCZ risk. Methods: We first selected five independent single-nucleotide polymorphisms (SNPs) associated with three SNPs sOB-R from two genome-wide association (GWASs) European individuals. Then, extracted...
Diaphorina citri (Hemiptera: Liviidae) is a vector for the citrus Huanglongbing greening disease, which can reduce crop yields. Harmonia axyridis (Coleoptera: Coccinellidae) known to prey on D. nymphs; we investigated predation capacity and functional response of H. adult citri. larvae exhibited Holling's type II different densities For second, third fourth instar larvae, successful attack rates were 0.75 ± 0.22, 1.06 0.11, 1.04 0.26, respectively; handling times 18.08 5.37, 0.45 0.07, 0.24...
This study aimed to identify stromal molecular signatures associated with breast and prostate cancer. The microarray data GSE26910 was downloaded from Gene Expression Omnibus database, including six invasive tumor stroma, matched normal controls, controls. differentially expressed genes (DEGs) in tumors stroma were, respectively, identified. Then common (B_P.DEGs) were further screened. Protein–protein interaction (PPI) network constructed Ontology analysis performed. Besides, gene–chemical...
This case report presents the rare occurrence of hematochezia due to an internal iliac artery aneurysm leading arterioenteric fistula, expanding differential diagnosis for gastrointestinal bleeding. It emphasizes importance considering vascular origins in cases atypical hematochezia, particularly absence common causes, and highlights role imaging multidisciplinary management diagnosing treating such unusual presentations.
Serum levels of carbohydrate antigen 19-9 (CA 19-9) were shown to be associated with poorer prognosis in several cancers, but the prognostic role CA patients hepatocellular carcinoma was unclear. A retrospective cohort 97 resectable performed assess on overall survival carcinoma. Both Kaplan-Meier product-limit method and multivariate analysis determine levels. The results indicated that among those patients, 24 (24.7%) had elevated preoperative (≥37 U/mL). Elevated serum did not correlate...
Preeclampsia (PE) is a pregnancy disorder characterized by excessive trophoblast cell death. This study aims to explore the exact mechanism of ubiquitination level FUN14 domain containing 1 (FUNDC1) in mitophagy and injury hypoxic cells. In this study, HTR-8/SVneo cells were cultured under normoxic conditions PE mouse model was established. We found low FUNDC1 placenta pregnant women with PE. Proteasome inhibitor MG-132 protease activator MF-094 added into decreased while increased level....
Ovarian cancer is a highly deadly disease, which often diagnosed at late stage with metastases. However, most ovarian cancers relapse after surgery combined platinum-based chemotherapy. Cancer stem cells (CSCs) are stem-like that possess high tumorigenic capability and display higher resistant against current therapies. our knowledge of CSCs their molecular mechanism remains sparse. In the study, we found KDM4C, histone demethylase, was required for cell (CSC) maintenance. Depletion KDM4C...