A5027962087- Developmental Biology and Gene Regulation
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Malaria Research and Control
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Hippo pathway signaling and YAP/TAZ
- Invertebrate Immune Response Mechanisms
- Cellular Mechanics and Interactions
- Animal Genetics and Reproduction
- Epigenetics and DNA Methylation
- Marine Invertebrate Physiology and Ecology
- Neurobiology and Insect Physiology Research
- Chromosomal and Genetic Variations
- Mosquito-borne diseases and control
- Protist diversity and phylogeny
- Ubiquitin and proteasome pathways
- Marine Ecology and Invasive Species
- Coral and Marine Ecosystems Studies
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Cellular transport and secretion
- Bacteriophages and microbial interactions
- Axon Guidance and Neuronal Signaling
The University of Melbourne
2010-2020
Flinders University
2016-2020
The University of Adelaide
2000-2015
Australian National University
2002-2015
The University of Queensland
2010
In-Q-Tel
2010
ARC Centre of Excellence in Advanced Molecular Imaging
2010
National Health and Medical Research Council
2007
James Cook University
2002
Yale University
2000
STIM1 (where STIM is stromal interaction molecule) a candidate tumour suppressor gene that maps to human chromosome 11p15.5, region implicated in variety of cancers, particularly embryonal rhabdomyosarcoma. codes for transmembrane phosphoprotein whose structure unrelated any other known proteins. The precise pathway by which regulates cell growth not known. In the present study we screened databases STIM1-related sequences, and have identified characterized cDNA sequences representing single...
Sergei N. Prokopenko, Anthony Brumby, Louise O'Keefe, Leanne Prior, Yuchun He, Robert Saint, and Hugo J. Bellen Program in Developmental Biology, Howard Hughes Medical Institute, Department of Molecular Human Genetics, Baylor College Medicine, Houston, Texas 77030 USA; University Adelaide, Adelaide SA 5005, Australia
STIM1 (where STIM is stromal interaction molecule) a candidate tumour suppressor gene that maps to human chromosome 11p15.5, region implicated in variety of cancers, particularly embryonal rhabdomyosarcoma. codes for transmembrane phosphoprotein whose structure unrelated any other known proteins. The precise pathway by which regulates cell growth not known. In the present study we screened databases STIM1-related sequences, and have identified characterized cDNA sequences representing single...
Many proteins produced by blood stages of the malaria parasite Plasmodium falciparum are natural immunogens in man. As an approach to determining which these relevant protective immunity we have constructed expression library P. cDNA sequences, cloned Escherichia coli. The sequences were inserted into beta-galactosidase gene ampicillin-resistant derivative temperature-sensitive lysogenic bacteriophage lambda gt11. About 5% resulting clones expressed as polypeptides fused beta-galactosidase....
The 3′ untranslated regions (3′UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers 3′UTRs in human, mouse fly are also expressed separately from the associated protein-coding sequences to which they normally linked, likely by post-transcriptional cleavage. Analysis CAGE (capped analysis gene expression), SAGE (serial expression) cDNA libraries, as well microarray expression profiles, demonstrate independent is a...
We have generated Drosophila melanogaster lines carrying a modified genomic fragment which encodes the D. variant H2A.F/Z class histone, His2AvD, fused to green fluorescent protein (GFP) of jellyfish Aequorea victoria. show here that fusion consists functional GFP and histone His2AvD. The His2AvD portion gene was shown be by rescue mutant lethality. Fluorescence in vivo observed embryonic cleavage stage interphase nuclei on chromosomes as early cycle 9, correlating with activation...
The 77-kb primary transcript of the homeotic Ultrabithorax (Ubx) gene is alternatively spliced to yield at least five different coding regions. Each restricted either a 3.2- or 4.3-kb size class generated by alternative polyadenylation. pathways for splicing and polyadenylation are therefore coordinately regulated, because relative abundance respective mRNAs varies throughout development, these also appear be developmentally regulated. Translation yields family Ubx proteins characterized...
We reported the identification of a new family DNA-binding proteins from our characterization dead ringer (dri) gene Drosophila melanogaster. show that dri encodes nuclear protein contains sequence-specific domain bears no similarity to known domains. A number were found contain sequences homologous this domain. Other containing conserved motif include yeast SWI1, two human retinoblastoma binding proteins, and other mammalian regulatory proteins. mouse B-cell-specific regulator exhibits 75%...
Immunoelectron microscopy with protein A gold has been used to determine the subcellular location of ring-infected erythrocyte surface antigen (RESA) Plasmodium falciparum. RESA was associated dense vesicles presumed be micronemes within merozoites. not detected on merozoites but located at membrane erythrocytes infected ring-stage parasites. largely soluble in nonionic detergent Triton X-100, insoluble this when membrane.
ABSTRACT The Polycomblike gene of Drosophila melanogaster, a member the Polycomb Group genes, is required for correct spatial expression homeotic genes Antennapaedia and Bithorax Complexes. Mutations in result ectopic expression, indicating that proteins maintain transcriptional repression specific tissues during development. We report here isolation molecular characterisation gene. transcript encodes an 857 amino acid protein with no significant homology to other proteins. Antibodies raised...
ABSTRACT We have isolated a Drosophila homolog of the human G1-specific cyclin E gene. Cyclin proteins thus constitute an evolutionarily conserved subfamily metazoan cyclins. The gene, DmcycE, encodes two with common C-terminal region and unique N-terminal regions. Unlike other cyclins, DmcycE exhibits dynamic pattern expression during development. is supplied maternally, but at completion cleavage divisions prior to mitosis 14, maternal transcripts are rapidly degraded in all cells except...
Abstract Background Anthozoan cnidarians are amongst the simplest animals at tissue level of organization, but surprisingly complex and vertebrate-like in terms gene repertoire. As major components tropical reef ecosystems, stony corals anthozoans particular ecological significance. To better understand molecular bases both cnidarian development general coral-specific processes such as skeletogenesis symbiont acquisition, microarray analysis was carried out through period early – when is...